Low level DUX4 expression disrupts myogenesis through deregulation of myogenic gene expression (Q59340018)

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Micah D Gearhart

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Erik A Toso

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Elizabeth T Ener

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Si Ho Choi

Population-based incidence and prevalence of facioscapulohumeral dystrophy

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language of work or name

English

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publication date

16 November 2018

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published in

Scientific Reports

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volume

8

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issue

1

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page(s)

16957

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cites work

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Inappropriate Gene Activation in FSHD

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Specific loss of histone H3 lysine 9 trimethylation and HP1gamma/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD).

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Hypomethylation of D4Z4 in 4q-linked and non-4q-linked facioscapulohumeral muscular dystrophy

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Common epigenetic changes of D4Z4 in contraction-dependent and contraction-independent FSHD.

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Digenic inheritance of an SMCHD1 mutation and an FSHD-permissive D4Z4 allele causes facioscapulohumeral muscular dystrophy type 2

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

FSHD associated DNA rearrangements are due to deletions of integral copies of a 3.2 kb tandemly repeated unit

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Mutations in DNMT3B Modify Epigenetic Repression of the D4Z4 Repeat and the Penetrance of Facioscapulohumeral Dystrophy.

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

A unifying genetic model for facioscapulohumeral muscular dystrophy

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy.

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes.

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Wnt/β-catenin signaling suppresses DUX4 expression and prevents apoptosis of FSHD muscle cells.

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Dominant lethal pathologies in male mice engineered to contain an X-linked DUX4 transgene

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

DUX4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesis

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Endogenous DUX4 expression in FSHD myotubes is sufficient to cause cell death and disrupts RNA splicing and cell migration pathways

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Expression profiling of FSHD muscle supports a defect in specific stages of myogenic differentiation.

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

MyoD or Myf-5 is required for the formation of skeletal muscle

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

DUX4c, an FSHD candidate gene, interferes with myogenic regulators and abolishes myoblast differentiation

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Identification and analysis of putative regulatory sequences for the MYF5/MYF6 locus in different vertebrate species

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Myoblasts from affected and non-affected FSHD muscles exhibit morphological differentiation defects

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

A family history of DUX4: phylogenetic analysis of DUXA, B, C and Duxbl reveals the ancestral DUX gene

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

DNA-binding sequence specificity of DUX4.

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021

DUX4 promotes transcription of FRG2 by directly activating its promoter in facioscapulohumeral muscular dystrophy

1 reference

https://api.crossref.org/works/10.1038/S41598-018-35150-8

7 January 2021