The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease (Q59133137)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30224383 AND SRC:MED&resulttype=core&format=json

22 April 2020

title

The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease (English)

1 reference

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22 April 2020

0 references

1 reference

1

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22 April 2020

Laura H Jacobson

3

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22 April 2020

Cristina Lopez Lopez

32

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22 April 2020

author name string

Mike Ufer

2

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22 April 2020

Marie-Laure Rouzade-Dominguez

4

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22 April 2020

Gunilla Huledal

5

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22 April 2020

Carine Kolly

6

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22 April 2020

Rainer M Lüönd

7

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22 April 2020

Rainer Machauer

8

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22 April 2020

Siem J Veenstra

9

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22 April 2020

Konstanze Hurth

10

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22 April 2020

Heinrich Rueeger

11

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22 April 2020

Marina Tintelnot-Blomley

12

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22 April 2020

Derya R Shimshek

14

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22 April 2020

Ludovic Perrot

15

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22 April 2020

Wilfried Frieauff

16

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22 April 2020

Valerie Dubost

17

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22 April 2020

Hilmar Schiller

18

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22 April 2020

Barbara Vogg

19

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22 April 2020

Karen Beltz

20

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22 April 2020

Alexandre Avrameas

21

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22 April 2020

Sandrine Kretz

22

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22 April 2020

Nicole Pezous

23

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22 April 2020

Jean-Michel Rondeau

24

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22 April 2020

Nicolau Beckmann

25

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22 April 2020

Andreas Hartmann

26

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22 April 2020

Stefan Vormfelde

27

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22 April 2020

Olivier J David

28

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22 April 2020

Bruno Galli

29

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22 April 2020

Rita Ramos

30

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22 April 2020

Ana Graf

31

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22 April 2020

Matthias Staufenbiel

13

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22 April 2020

language of work or name

English

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publication date

1 November 2018

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22 April 2020

published in

EMBO Molecular Medicine

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22 April 2020

volume

10

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22 April 2020

issue

11

1 reference

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Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer's Disease.

22 April 2020

page(s)

e9316

0 references

cites work

1 reference

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Trial of Solanezumab for Mild Dementia Due to Alzheimer's Disease

30 November 2018

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Binding modes of hERG blockers: an unsolved mystery in the drug design arena

30 November 2018

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Forecasting the prevalence of preclinical and clinical Alzheimer's disease in the United States.

30 November 2018

1 reference

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Reversible and Species-Specific Depigmentation Effects of AZD3293, a BACE Inhibitor for the Treatment of Alzheimer's Disease, Are Related to BACE2 Inhibition and Confined to Epidermis and Hair

30 November 2018

1 reference

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The Alzheimer's Prevention Initiative Generation Program: Evaluating CNP520 Efficacy in the Prevention of Alzheimer's Disease

30 November 2018

1 reference

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Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor

30 November 2018

1 reference

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Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage

30 November 2018

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BACE inhibition-dependent repair of Alzheimer's pathophysiology

30 November 2018

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APOEɛ4 Genotype, Amyloid, and Clinical Disease Progression in Cognitively Normal Older Adults

30 November 2018

1 reference

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Merck ends trial of potential Alzheimer's drug verubecestat

30 November 2018

1 reference

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BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants

30 November 2018

1 reference

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The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients

30 November 2018

1 reference

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AZD3293: Pharmacokinetic and Pharmacodynamic Effects in Healthy Subjects and Patients with Alzheimer's Disease

30 November 2018

1 reference

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Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition

30 November 2018

1 reference

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Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Reference measurement procedure for CSF amyloid beta (Aβ)1-42 and the CSF Aβ1-42 /Aβ1-40 ratio - a cross-validation study against amyloid PET.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

CSF Aβ42/Aβ40 and Aβ42/Aβ38 ratios: better diagnostic markers of Alzheimer disease

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

The amyloid hypothesis of Alzheimer's disease at 25 years

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Cascading network failure across the Alzheimer's disease spectrum

30 November 2018

1 reference

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A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

30 November 2018

1 reference

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Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse

30 November 2018

1 reference

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Age and amyloid effects on human central nervous system amyloid-beta kinetics

30 November 2018

1 reference

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Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis

30 November 2018

1 reference

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The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

The evolution of preclinical Alzheimer's disease: implications for prevention trials

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Alzheimer's therapeutics: continued clinical failures question the validity of the amyloid hypothesis-but what lies beyond?

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Robust Central Reduction of Amyloid-β in Humans with an Orally Available, Non-Peptidic β-Secretase Inhibitor

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Designing drugs to avoid toxicity

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Noninvasive magnetic resonance imaging detection of cerebral amyloid angiopathy-related microvascular alterations using superparamagnetic iron oxide particles in APP transgenic mouse models of Alzheimer's disease: application to passive Abeta immuno

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Control of peripheral nerve myelination by the beta-secretase BACE1

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Pathogenic mechanisms of Alzheimer's disease analyzed in the APP23 transgenic mouse model

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

On the size of the active site in proteases. I. Papain

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6220303

Inflammatory processes in Alzheimer's disease

30 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/30224383

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.15252/EMMM.201809316

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30224383 AND SRC:MED&resulttype=core&format=json

22 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30224383 AND SRC:MED&resulttype=core&format=json

22 April 2020

PubMed publication ID

30224383

1 reference