Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death (Q59127592)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30260955 AND SRC:MED&resulttype=core&format=json

24 April 2020

title

Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death (English)

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24 April 2020

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5

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24 April 2020

Ye-Guang Chen

8

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24 April 2020

author name string

Pan Ye

1

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24 April 2020

Y Jeffrey Chiang

2

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24 April 2020

Zhen Qi

3

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24 April 2020

Yehua Li

4

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24 April 2020

Yuan Liu

6

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24 April 2020

Xintong Li

7

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24 April 2020

language of work or name

English

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publication date

27 September 2018

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24 April 2020

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24 April 2020

volume

14

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24 April 2020

issue

9

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24 April 2020

page(s)

e1007697

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Creative Commons CC0 License

24 April 2020

copyright license

start time

27 September 2018

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April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

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cites work

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IWR-1, a tankyrase inhibitor, attenuates Wnt/β-catenin signaling in cancer stem-like cells and inhibits in vivo the growth of a subcutaneous human osteosarcoma xenograft

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Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade.

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Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines.

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The ADP-ribose polymerase Tankyrase regulates adult intestinal stem cell proliferation during homeostasis in Drosophila

30 November 2018

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Tankyrase Inhibition Causes Reversible Intestinal Toxicity in Mice with a Therapeutic Index < 1.

30 November 2018

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Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells

30 November 2018

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The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5 stem cells

30 November 2018

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Poly(ADP-ribose): a signaling molecule in different paradigms of cell death

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The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines

30 November 2018

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The intestinal crypt, a prototype stem cell compartment

30 November 2018

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Canonical Wnt signals combined with suppressed TGFβ/BMP pathways promote renewal of the native human colonic epithelium

30 November 2018

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30 November 2018

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Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway

30 November 2018

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A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.

30 November 2018

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30 November 2018

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30 November 2018

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30 November 2018

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A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.

30 November 2018

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A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal

30 November 2018

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The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

30 November 2018

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Lrp5 and Lrp6 play compensatory roles in mouse intestinal development

30 November 2018

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Stem cell self-renewal in intestinal crypt

30 November 2018

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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

30 November 2018

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30 November 2018

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30 November 2018

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Tankyrase is necessary for canonical Wnt signaling during kidney development

30 November 2018

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

30 November 2018

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Hypermetabolism, hyperphagia, and reduced adiposity in tankyrase-deficient mice

30 November 2018

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30 November 2018

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OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells

30 November 2018

1 reference

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Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

30 November 2018

1 reference

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Gastrointestinal stem cells in development and cancer

30 November 2018

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Stem cells, self-renewal, and differentiation in the intestinal epithelium

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177203

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177203

Identification of stem cells in small intestine and colon by marker gene Lgr5

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177203

Tankyrase function at telomeres, spindle poles, and beyond.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177203

Phases of canonical Wnt signaling during the development of mouse intestinal epithelium

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177203

The Intestinal Wnt/TCF Signature.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177203

Identification of genes regulated by Wnt/beta-catenin pathway and involved in apoptosis via microarray analysis

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177203

Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177203

Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and capping

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177203

Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177203

Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177203

NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177203

Wnt signaling in the intestinal epithelium: from endoderm to cancer

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177203

Signaling pathways in intestinal development and cancer

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177203

Resolution of sister telomere association is required for progression through mitosis

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177203

Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177203

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177203

Tankyrase promotes telomere elongation in human cells

30 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/30260955

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.1007697

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30260955 AND SRC:MED&resulttype=core&format=json

24 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30260955 AND SRC:MED&resulttype=core&format=json

24 April 2020

PubMed publication ID

30260955

1 reference