Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem (Q58714472)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30139933 AND SRC:MED&resulttype=core&format=json

19 April 2020

title

Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem (English)

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19 April 2020

0 references

1

1 reference

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19 April 2020

Gregory J Anderson

9

1 reference

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19 April 2020

Yuliang Zhao

10

1 reference

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19 April 2020

Guangjun Nie

11

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19 April 2020

author name string

Yiye Li

2

1 reference

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19 April 2020

Ying Xu

3

1 reference

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19 April 2020

Xiao Zhao

4

1 reference

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19 April 2020

Yinlong Zhang

5

1 reference

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19 April 2020

Xiao Yang

6

1 reference

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19 April 2020

Yongwei Wang

7

1 reference

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19 April 2020

Ruifang Zhao

8

1 reference

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19 April 2020

language of work or name

English

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publication date

23 August 2018

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19 April 2020

published in

Nature Communications

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19 April 2020

volume

9

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19 April 2020

issue

1

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19 April 2020

page(s)

3390

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Designing Liposomes To Suppress Extracellular Matrix Expression To Enhance Drug Penetration and Pancreatic Tumor Therapy

19 April 2020

cites work

1 reference

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Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer

30 November 2018

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Targeting Tumor-Associated Fibroblasts for Therapeutic Delivery in Desmoplastic Tumors

30 November 2018

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Ultrasensitive pH Triggered Charge/Size Dual-Rebound Gene Delivery System

30 November 2018

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Generation of an in vitro 3D PDAC stroma rich spheroid model.

30 November 2018

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ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

30 November 2018

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Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles.

30 November 2018

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Nanomedicine strategies to overcome the pathophysiological barriers of pancreatic cancer

30 November 2018

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Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model.

30 November 2018

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Cyclopamine disrupts tumor extracellular matrix and improves the distribution and efficacy of nanotherapeutics in pancreatic cancer.

30 November 2018

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Locally Advanced, Unresectable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline.

30 November 2018

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Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer.

30 November 2018

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An MMP-2 Responsive Liposome Integrating Antifibrosis and Chemotherapeutic Drugs for Enhanced Drug Perfusion and Efficacy in Pancreatic Cancer

30 November 2018

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Tumor Acidity-Sensitive Polymeric Vector for Active Targeted siRNA Delivery

30 November 2018

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Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer

30 November 2018

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Stimuli-responsive nanoparticles for targeting the tumor microenvironment.

30 November 2018

1 reference

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Dermal delivery of HSP47 siRNA with NOX4-modulating mesoporous silica-based nanoparticles for treating fibrosis.

30 November 2018

1 reference

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Stromal biology and therapy in pancreatic cancer: a changing paradigm

30 November 2018

1 reference

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siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown.

30 November 2018

1 reference

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Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network

30 November 2018

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Homeostatic Restoration of Desmoplastic Stroma Rather Than Its Ablation Slows Pancreatic Cancer Progression

30 November 2018

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Experimental approaches for measuring pKa's in RNA and DNA.

30 November 2018

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Localized electric field of plasmonic nanoplatform enhanced photodynamic tumor therapy.

30 November 2018

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Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy

30 November 2018

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Stromal reengineering to treat pancreas cancer

30 November 2018

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Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

30 November 2018

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Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma

30 November 2018

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Gold nanoparticles for nucleic acid delivery.

30 November 2018

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Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine

30 November 2018

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Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

30 November 2018

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Activated pancreatic stellate cells sequester CD8 T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma

30 November 2018

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The polyethyleneglycol dilemma: advantage and disadvantage of PEGylation of liposomes for systemic genes and nucleic acids delivery to tumors.

30 November 2018

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Cytokines as biomarkers of nanoparticle immunotoxicity

30 November 2018

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Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes.

30 November 2018

1 reference

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Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

30 November 2018

1 reference

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Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression

30 November 2018

1 reference

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Five years of siRNA delivery: spotlight on gold nanoparticles.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6107580

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6107580

Three-Dimensional Collagen I Promotes Gemcitabine Resistance in Pancreatic Cancer through MT1-MMP–Mediated Expression of HMGA2

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6107580

Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6107580

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

30 November 2018

1 reference

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Preparation of multifunctional drug carrier for tumor-specific uptake and enhanced intracellular delivery through the conjugation of weak acid labile linker

30 November 2018

1 reference

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Layer-by-layer assembled gold nanoparticles for siRNA delivery.

30 November 2018

1 reference

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Signal transduction in pancreatic stellate cells

30 November 2018

1 reference

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Efficient gene delivery vectors by tuning the surface charge density of amino acid-functionalized gold nanoparticles

30 November 2018

1 reference

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Gene regulation with polyvalent siRNA-nanoparticle conjugates

30 November 2018

1 reference

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Entrapment of hydrophobic drugs in nanoparticle monolayers with efficient release into cancer cells

30 November 2018

1 reference

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Pancreatic stellate cells: partners in crime with pancreatic cancer cells

30 November 2018

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Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone

30 November 2018

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Cancer-associated stromal fibroblasts promote pancreatic tumor progression

30 November 2018

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pH-triggered reversible "stealth" polycationic micelles.

30 November 2018

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Palmitic acid substitution on cationic polymers for effective delivery of plasmid DNA to bone marrow stromal cells

30 November 2018

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Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers

30 November 2018

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The role of disturbed pH dynamics and the Na /H exchanger in metastasis.

30 November 2018

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Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis

30 November 2018

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Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells

30 November 2018

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Regulation of pancreatic stellate cell function in vitro: biological and molecular effects of all-trans retinoic acid

30 November 2018

1 reference

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Discovery of novel tumor markers of pancreatic cancer using global gene expression technology

30 November 2018

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Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo

30 November 2018

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Identification, culture, and characterization of pancreatic stellate cells in rats and humans

30 November 2018

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A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

30 November 2018

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HSP47 siRNA conjugated with cationized gelatin microspheres suppresses peritoneal fibrosis in mice

30 November 2018

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7 January 2021

Immunohistochemical validation of a novel epithelial and a novel stromal marker of pancreatic ductal adenocarcinoma identified by global expression microarrays: sea urchin fascin homolog and heat shock protein 47

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7 January 2021

Controlling the Neuronal Differentiation of Stem Cells by the Intracellular Delivery of Retinoic Acid-Loaded Nanoparticles

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https://api.crossref.org/works/10.1038/S41467-018-05906-X

7 January 2021

Precise engineering of siRNA delivery vehicles to tumors using polyion complexes and gold nanoparticles

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7 January 2021

10.1038/S41467-018-05906-X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30139933 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

19 April 2020

ADS bibcode

2018NatCo...9.3390H

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30139933 AND SRC:MED&resulttype=core&format=json

19 April 2020

PubMed publication ID

30139933

1 reference