Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats (Q58641838)

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18 January 2020

title

Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats (English)

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author name string

Joel M Reid

1

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18 January 2020

Sarah A Buhrow

2

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18 January 2020

Mary J Kuffel

3

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Victoria J Spanswick

5

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John A Hartley

6

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David E Thurston

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Joseph E Tomaszewski

8

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Matthew M Ames

9

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publication date

28 December 2010

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Cancer Chemotherapy and Pharmacology

18 January 2020

published in

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volume

68

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issue

3

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page(s)

777-786

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Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.

18 January 2020

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Cellular pharmacology of novel C8-linked anthramycin-based sequence-selective DNA minor groove cross-linking agents

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SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations

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SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity

21 January 2018

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The novel sequence-specific DNA cross-linking agent SJG-136 (NSC 694501) has potent and selective in vitro cytotoxicity in human B-cell chronic lymphocytic leukemia cells with evidence of a p53-independent mechanism of cell kill

21 January 2018

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Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers

21 January 2018

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The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links.

21 January 2018

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Phase I study of sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors

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Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent.

21 January 2018

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Measurement of drug-induced DNA interstrand crosslinking using the single-cell gel electrophoresis (comet) assay.

21 January 2018

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A public domain image-analysis program for the single-cell gel-electrophoresis (comet) assay

21 January 2018

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LC–MS/MS assay and dog pharmacokinetics of the dimeric pyrrolobenzodiazepine SJG-136 (NSC 694501)

21 January 2018

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Cytochrome P-450 3A4: regulation and role in drug metabolism

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Cytochromes P-450 in rats: structures, functions, properties and relevant human forms

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Repair of DNA interstrand crosslinks as a mechanism of clinical resistance to melphalan in multiple myeloma.

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Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material

21 January 2018

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21 January 2018

Identifiers

DOI

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18 January 2020

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