Nitric Oxide Synthase Enzymology in the Twenty Years After the Nobel Prize (Q58605841)

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2 May 2020

title

Nitric oxide synthase enzymology in the 20 years after the Nobel Prize (English)

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2 May 2020

1

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2 May 2020

author name string

Mohammad Mahfuzul Haque

series ordinal

2

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2 May 2020

language of work or name

English

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publication date

9 December 2018

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British Journal of Pharmacology

2 May 2020

published in

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2 May 2020

volume

176

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2 May 2020

issue

2

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2 May 2020

page(s)

177-188

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Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase

2 May 2020

cites work

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12 December 2020

Nitric oxide synthases in mammals

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12 December 2020

Iron regulates nitric oxide synthase activity by controlling nuclear transcription

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12 December 2020

Nitric oxide synthase: Aspects concerning structure and catalysis

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12 December 2020

Calmodulin controls neuronal nitric-oxide synthase by a dual mechanism. Activation of intra- and interdomain electron transfer

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12 December 2020

Nitric oxide-mediated inactivation of mammalian ferrochelatase in vivo and in vitro: possible involvement of the iron-sulphur cluster of the enzyme

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12 December 2020

Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: structure studies of a cysteine thiolate-liganded heme protein that hydroxylates L-arginine to produce NO. as a cellular signal.

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12 December 2020

Intracellular assembly of inducible NO synthase is limited by nitric oxide-mediated changes in heme insertion and availability

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12 December 2020

Reduction of quinonoid dihydrobiopterin to tetrahydrobiopterin by nitric oxide synthase

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12 December 2020

Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1

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12 December 2020

Nitric oxide binding to the heme of neuronal nitric-oxide synthase links its activity to changes in oxygen tension

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12 December 2020

Structure-function aspects in the nitric oxide synthases

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12 December 2020

The ferrous-dioxy complex of neuronal nitric oxide synthase. Divergent effects of L-arginine and tetrahydrobiopterin on its stability

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12 December 2020

Analysis of Neuronal NO Synthase under Single-Turnover Conditions: Conversion ofNω-Hydroxyarginine to Nitric Oxide and Citrulline

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12 December 2020

Comparative Functioning of Dihydro- and Tetrahydropterins in Supporting Electron Transfer, Catalysis, and Subunit Dimerization in Inducible Nitric Oxide Synthase

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12 December 2020

Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism

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12 December 2020

Structure of nitric oxide synthase oxygenase dimer with pterin and substrate

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12 December 2020

Stopped-Flow Analysis of CO and NO Binding to Inducible Nitric Oxide Synthase

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12 December 2020

Reactions catalyzed by tetrahydrobiopterin-free nitric oxide synthase

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12 December 2020

Antifungal imidazoles block assembly of inducible NO synthase into an active dimer

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12 December 2020

Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center

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12 December 2020

Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase. Implications for mechanism

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12 December 2020

Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors

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12 December 2020

Reactions catalyzed by the heme domain of inducible nitric oxide synthase: evidence for the involvement of tetrahydrobiopterin in electron transfer

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12 December 2020

Control of nitric oxide synthase dimer assembly by a heme-NO-dependent mechanism

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12 December 2020

Tetrahydrobiopterin in nitric oxide synthesis: a novel biological role for pteridines.

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12 December 2020

Crystal structure of the ascorbate peroxidase-ascorbate complex

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12 December 2020

A tetrahydrobiopterin radical forms and then becomes reduced during Nomega-hydroxyarginine oxidation by nitric-oxide synthase

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12 December 2020

Structural Elements Contribute to the Calcium/Calmodulin Dependence on Enzyme Activation in Human Endothelial Nitric-oxide Synthase

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12 December 2020

Dynamic regulation of the inducible nitric-oxide synthase by NO: comparison with the endothelial isoform.

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12 December 2020

Update on mechanism and catalytic regulation in the NO synthases.

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12 December 2020

Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.

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12 December 2020

The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation

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12 December 2020

S-Nitrosation and regulation of inducible nitric oxide synthase

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12 December 2020

Exploring the redox reactions between heme and tetrahydrobiopterin in the nitric oxide synthases

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12 December 2020

The regulation and pharmacology of endothelial nitric oxide synthase

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12 December 2020

Regulation of the monomer-dimer equilibrium in inducible nitric-oxide synthase by nitric oxide.

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12 December 2020

Nitrosyl-heme structures of Bacillus subtilis nitric oxide synthase have implications for understanding substrate oxidation

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12 December 2020

Electron transfer by neuronal nitric-oxide synthase is regulated by concerted interaction of calmodulin and two intrinsic regulatory elements

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12 December 2020

Conformational and Thermodynamic Control of Electron Transfer in Neuronal Nitric Oxide Synthase†

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12 December 2020

Substrate- and isoform-specific dioxygen complexes of nitric oxide synthase.

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12 December 2020

Versatile regulation of neuronal nitric oxide synthase by specific regions of its C-terminal tail.

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12 December 2020

Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase.

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12 December 2020

Phosphorylation within an autoinhibitory domain in endothelial nitric oxide synthase reduces the Ca(2 ) concentrations required for calmodulin to bind and activate the enzyme

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12 December 2020

Deletion of the autoregulatory insert modulates intraprotein electron transfer in rat neuronal nitric oxide synthase.

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12 December 2020

Exploring the electron transfer properties of neuronal nitric-oxide synthase by reversal of the FMN redox potential

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12 December 2020

The second step of the nitric oxide synthase reaction: evidence for ferric-peroxo as the active oxidant

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12 December 2020

Density functional theory (DFT) and combined quantum mechanical/molecular mechanics (QM/MM) studies on the oxygen activation step in nitric oxide synthase enzymes

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12 December 2020

Neutralizing a surface charge on the FMN subdomain increases the activity of neuronal nitric-oxide synthase by enhancing the oxygen reactivity of the enzyme heme-nitric oxide complex

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12 December 2020

Fast ferrous heme-NO oxidation in nitric oxide synthases

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12 December 2020

Regulation of interdomain interactions by calmodulin in inducible nitric-oxide synthase

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12 December 2020

How does a valine residue that modulates heme-NO binding kinetics in inducible NO synthase regulate enzyme catalysis?

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12 December 2020

Nitric oxide blocks cellular heme insertion into a broad range of heme proteins

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12 December 2020

Pterin-centered radical as a mechanistic probe of the second step of nitric oxide synthase.

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12 December 2020

A bridging interaction allows calmodulin to activate NO synthase through a bi-modal mechanism

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12 December 2020

Pulsed EPR determination of the distance between heme iron and FMN centers in a human inducible nitric oxide synthase.

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12 December 2020

GAPDH regulates cellular heme insertion into inducible nitric oxide synthase

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12 December 2020

Hsp90 interacts with inducible NO synthase client protein in its heme‐free state and then drives heme insertion by an ATP‐dependent process

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12 December 2020

Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors

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12 December 2020

Modulation of Heme/Substrate Binding Cleft of Neuronal Nitric-oxide Synthase (nNOS) Regulates Binding of Hsp90 and Hsp70 Proteins and nNOS Ubiquitination

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12 December 2020

Control of Electron Transfer and Catalysis in Neuronal Nitric-oxide Synthase (nNOS) by a Hinge Connecting Its FMN and FAD-NADPH Domains

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12 December 2020

Calmodulin activates neuronal nitric oxide synthase by enabling transitions between conformational states

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12 December 2020

Charge-pairing interactions control the conformational setpoint and motions of the FMN domain in neuronal nitric oxide synthase

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12 December 2020

Reactive intermediates in cytochrome p450 catalysis

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12 December 2020

Nitric oxide synthase domain interfaces regulate electron transfer and calmodulin activation

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12 December 2020

Architecture of the nitric-oxide synthase holoenzyme reveals large conformational changes and a calmodulin-driven release of the FMN domain

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12 December 2020

Molecular architecture of mammalian nitric oxide synthases

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12 December 2020

Holoenzyme structures of endothelial nitric oxide synthase - an allosteric role for calmodulin in pivoting the FMN domain for electron transfer

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12 December 2020

Enzymatic and cryoreduction EPR studies of the hydroxylation of methylated N(ω)-hydroxy-L-arginine analogues by nitric oxide synthase from Geobacillus stearothermophilus

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12 December 2020

Distinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles

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12 December 2020

Fluorescence quenching studies of structure and dynamics in calmodulin-eNOS complexes

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12 December 2020

Insight into structural rearrangements and interdomain interactions related to electron transfer between flavin mononucleotide and heme in nitric oxide synthase: A molecular dynamics study

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12 December 2020

Single-molecule spectroscopy reveals how calmodulin activates NO synthase by controlling its conformational fluctuation dynamics

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12 December 2020

Elucidating nitric oxide synthase domain interactions by molecular dynamics

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12 December 2020

Regulation of sGC via hsp90, Cellular Heme, sGC Agonists, and NO: New Pathways and Clinical Perspectives

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12 December 2020

A perspective on conformational control of electron transfer in nitric oxide synthases

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12 December 2020

Nitric oxide synthase in plants: Where do we stand?

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12 December 2020

Tetrahydrobiopterin redox cycling in nitric oxide synthase: evidence supports a through-heme electron delivery

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12 December 2020

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes

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12 December 2020

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

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12 December 2020

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY.

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12 December 2020

Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells

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12 December 2020

Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling

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12 December 2020

Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells

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12 December 2020

Identifiers

DOI

10.1111/BPH.14533

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30402946 AND SRC:MED&resulttype=core&format=json

2 May 2020

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2 May 2020

PubMed publication ID

30402946

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