Subcellular Localization and Activity of the Mitogen-activated Protein Kinase Kinase 7 (MKK7) γ Isoform are Regulated through Binding to the Phosphatase Calcineurin (Q58599315)

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scientific article published on 07 November 2018

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English	Subcellular Localization and Activity of the Mitogen-activated Protein Kinase Kinase 7 (MKK7) γ Isoform are Regulated through Binding to the Phosphatase Calcineurin	scientific article published on 07 November 2018

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2 May 2020

Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7 (MKK7) γ Isoform are Regulated through Binding to the Phosphatase Calcineurin (English)

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2 May 2020

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Emily S Gibson

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2 May 2020

Kevin M Woolfrey

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2 May 2020

Huiming Li

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Patrick G Hogan

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2 May 2020

Raphael A Nemenoff

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Lynn E Heasley

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2 May 2020

Mark L Dell'Acqua

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2 May 2020

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7 November 2018

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2 May 2020

Molecular Pharmacology

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2 May 2020

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20-32

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2 May 2020

Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

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Gα16 Mimics Vasoconstrictor Action to Induce Smooth Muscle α-Actin in Vascular Smooth Muscle Cells through a Jun-NH2-terminal Kinase-dependent Pathway

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https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

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Vasopressin signaling pathways in vascular smooth muscle

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https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT

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https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

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Induction of smooth muscle alpha-actin in vascular smooth muscle cells by arginine vasopressin is mediated by c-Jun amino-terminal kinases and p38 mitogen-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

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Interaction of EGF receptor and grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy

1 reference

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12 December 2020

based on heuristic

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Mapping the protein phosphatase-2B anchoring site on AKAP79. Binding and inhibition of phosphatase activity are mediated by residues 315-360.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging kinase--AKAP79--phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NFAT regulation in smooth muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of SM22 alpha expression by arginine vasopressin and PDGF-BB in vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FRET two-hybrid mapping reveals function and location of L-type Ca2 channel CaM preassociation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutively elevated nuclear export activity opposes Ca2 -dependent NFATc3 nuclear accumulation in vascular smooth muscle: role of JNK2 and Crm-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural delineation of the calcineurin-NFAT interaction and its parallels to PP1 targeting interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear factor of activated T cells and serum response factor cooperatively regulate the activity of an alpha-actin intronic enhancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of NFAT activation by the second calcineurin binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome-wide atlas of gene expression in the adult mouse brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological roles of MKK4 and MKK7: insights from animal models

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2 channel activity and nuclear signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of calcineurin with substrates and targeting proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunolabeling artifacts and the need for live-cell imaging

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Balanced interactions of calcineurin with AKAP79 regulate Ca2 –calcineurin–NFAT signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2 -permeable AMPA receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localized calcineurin confers Ca2 -dependent inactivation on neuronal L-type Ca2 channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKAP-anchored PKA maintains neuronal L-type calcium channel activity and NFAT transcriptional signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The calcineurin signaling network evolves via conserved kinase-phosphatase modules that transcend substrate identity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The palmitoyl acyltransferase DHHC2 regulates recycling endosome exocytosis and synaptic potentiation through palmitoylation of AKAP79/150

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordination of Protein Phosphorylation and Dephosphorylation in Synaptic Plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/30404891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/MOL.118.113159

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30404891 AND SRC:MED&resulttype=core&format=json

2 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30404891 AND SRC:MED&resulttype=core&format=json

2 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30404891 AND SRC:MED&resulttype=core&format=json

2 May 2020

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