Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression (Q58561592)

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2 May 2020

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21 August 2020

8 September 2020

9 September 2020

8 February 2021

Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression (English)

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2 May 2020

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myeloid-derived suppressor cells

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21 August 2020

tumor microenvironment

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8 September 2020

0 references

1 reference

8 February 2021

1 reference

Christopher Groth

1

1 reference

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2 May 2020

Xiaoying Hu

2

1 reference

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2 May 2020

Rebekka Weber

3

1 reference

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2 May 2020

Viktor Fleming

4

1 reference

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2 May 2020

Viktor Umansky

7

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2 May 2020

language of work or name

English

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publication date

9 November 2018

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British Journal of Cancer

2 May 2020

1 January 2019

4 references

21 August 2020

8 September 2020

9 September 2020

8 February 2021

5 references

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2 May 2020

21 August 2020

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8 February 2021

120

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2 May 2020

issue

1

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2 May 2020

page(s)

16-25

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Creative Commons Attribution 4.0 International

2 May 2020

copyright license

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21 August 2020

8 September 2020

Human haematopoietic stem cell lineage commitment is a continuous process

8 February 2021

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Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow

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Immunosuppressive myeloid-derived suppressor cells are increased in splenocytes from cancer patients.

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Recruited monocytic myeloid-derived suppressor cells promote the arrest of tumor cells in the premetastatic niche through an IL-1β-mediated increase in E-selectin expression

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Granulocytic myeloid-derived suppressor cells promote angiogenesis in the context of multiple myeloma

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B cell regulation in cancer and anti-tumor immunity.

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Regulation of myeloid development and function by colony stimulating factors.

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Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF.

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Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells

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Interleukin-6 Trans-Signaling Pathway Promotes Immunosuppressive Myeloid-Derived Suppressor Cells via Suppression of Suppressor of Cytokine Signaling 3 in Breast Cancer

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7 January 2021

GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1- bone marrow progenitor cells into myeloid-derived suppressor cells

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GM-CSF signalling blockade and chemotherapeutic agents act in concert to inhibit the function of myeloid-derived suppressor cells in vitro

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Induction of myeloid-derived suppressor cells by tumor exosomes

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Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells

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Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner

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Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26.

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Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma.

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7 January 2021

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

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7 January 2021

Tumor microenvironment and myeloid-derived suppressor cells

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7 January 2021

CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function

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7 January 2021

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

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7 January 2021

PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment

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7 January 2021

Tumor-Produced Interleukin-8 Attracts Human Myeloid-Derived Suppressor Cells and Elicits Extrusion of Neutrophil Extracellular Traps (NETs).

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7 January 2021

Tumor microenvironmental conversion of natural killer cells into myeloid-derived suppressor cells

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7 January 2021

Gr-1 CD115 Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host

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7 January 2021

Cellular immune suppressor mechanisms in patients with hepatocellular carcinoma

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7 January 2021

Regulatory T Cells Stimulate B7-H1 Expression in Myeloid-Derived Suppressor Cells in ret Melanomas

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7 January 2021

Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth.

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7 January 2021

Characterization of Multiple Cytokine Combinations and TGF-β on Differentiation and Functions of Myeloid-Derived Suppressor Cells.

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7 January 2021

Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors

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7 January 2021

Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes

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Myeloid-derived suppressor cells: linking inflammation and cancer

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Myeloid-derived suppressor cells down-regulate L-selectin expression on CD4 and CD8 T cells

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Tumor-induced myeloid-derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct CD8 T-cell activation events

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Norepinephrine-induced myeloid-derived suppressor cells block T-cell responses via generation of reactive oxygen species

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7 January 2021

Oxidative stress regulates expression of VEGFR1 in myeloid cells: link to tumor-induced immune suppression in renal cell carcinoma.

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7 January 2021

Tumor-Expressed Inducible Nitric Oxide Synthase Controls Induction of Functional Myeloid-Derived Suppressor Cells through Modulation of Vascular Endothelial Growth Factor Release

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7 January 2021

Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Inhibits Tumor Immunity through the Accumulation of Myeloid-Derived Suppressor Cells.

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VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2.

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VEGF differentially activates STAT3 in microvascular endothelial cells

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7 January 2021

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

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7 January 2021

Myeloid-Derived Suppressor Cell Survival and Function Are Regulated by the Transcription Factor Nrf2.

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7 January 2021

Glycolysis regulates the expansion of myeloid-derived suppressor cells in tumor-bearing hosts through prevention of ROS-mediated apoptosis

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7 January 2021

Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species

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7 January 2021

Subpopulations of myeloid-derived suppressor cells impair T cell responses through independent nitric oxide-related pathways

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7 January 2021

Nitric oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-kappaB.

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7 January 2021

Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease

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7 January 2021

Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases

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7 January 2021

Generation of myeloid-derived suppressor cells using prostaglandin E2.

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7 January 2021

Prostaglandin E2 Leads to the Acquisition of DNMT3A-Dependent Tolerogenic Functions in Human Myeloid-Derived Suppressor Cells.

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7 January 2021

Relationship of VEGF/VEGFR with immune and cancer cells: staggering or forward?

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7 January 2021

Altered recognition of antigen is a mechanism of CD8 T cell tolerance in cancer

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7 January 2021

Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells.

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7 January 2021

Nitric Oxide Production by Myeloid Derived Suppressor Cells Plays a Role in Impairing Fc Receptor-Mediated Natural Killer Cell Function

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7 January 2021

Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice

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7 January 2021

Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes

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7 January 2021

Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives

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Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses

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7 January 2021

Regulation of T cell receptor CD3zeta chain expression by L-arginine

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7 January 2021

Arginase-1 is neither constitutively expressed in nor required for myeloid-derived suppressor cell-mediated inhibition of T-cell proliferation.

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7 January 2021

Transport of cystine and cysteine in mammalian cells

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7 January 2021

Low membrane transport activity for cystine in resting and mitogenically stimulated human lymphocyte preparations and human T cell clones

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7 January 2021

Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine

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7 January 2021

Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity

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7 January 2021

CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF-β-mTOR-HIF-1 signaling in patients with non-small cell lung cancer.

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7 January 2021

Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling

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7 January 2021

Metformin-induced reduction of CD39 and CD73 blocks myeloid-derived suppressor cell activity in patients with ovarian cancer

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7 January 2021

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity.

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7 January 2021

Classifying Cancers Based on T-cell Infiltration and PD-L1.

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7 January 2021

Monitoring immune responses in the tumor microenvironment

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7 January 2021

Circulating and Tumor Myeloid-derived Suppressor Cells in Resectable Non-small-cell Lung Cancer

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7 January 2021

The expression profiles and regulation of PD-L1 in tumor-induced myeloid-derived suppressor cells

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7 January 2021

Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab

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7 January 2021

Clinical Significance of Circulating CD33 CD11b HLA-DR- Myeloid Cells in Patients with Stage IV Melanoma Treated with Ipilimumab.

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7 January 2021

PD-L1 MDSCs are increased in HCC patients and induced by soluble factor in the tumor microenvironment.

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7 January 2021

Mechanisms and consequences of Jak-STAT signaling in the immune system.

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7 January 2021

Activated T cells sustain myeloid-derived suppressor cell-mediated immune suppression

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7 January 2021

Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein

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7 January 2021

Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells

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7 January 2021

Nuclear factor-kappaB regulates cyclooxygenase-2 expression and cell proliferation in human gastric cancer cells

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7 January 2021

Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells

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7 January 2021

IFN-γ regulates survival and function of tumor-induced CD11b Gr-1high myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1.

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7 January 2021

Myeloid-derived suppressor cells as regulators of the immune system

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7 January 2021

The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis

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7 January 2021

Human Tumor-Infiltrating Myeloid Cells: Phenotypic and Functional Diversity

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7 January 2021

Subsets of myeloid-derived suppressor cells in tumor-bearing mice

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7 January 2021

Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells

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7 January 2021

Neutrophils in cancer: neutral no more.

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7 January 2021

Transcriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils

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7 January 2021

Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients.

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7 January 2021

Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer.

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7 January 2021

Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression.

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7 January 2021

Gemcitabine reduces MDSCs, tregs and TGFβ-1 while restoring the teff/treg ratio in patients with pancreatic cancer

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7 January 2021

Regulatory T cells and myeloid-derived suppressor cells in the tumor microenvironment undergo Fas-dependent cell death during IL-2/αCD40 therapy

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7 January 2021

TLR8 ligation induces apoptosis of monocytic myeloid-derived suppressor cells.

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7 January 2021

PI3Kγ is a molecular switch that controls immune suppression

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7 January 2021

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

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7 January 2021

Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3Kδ/γ.

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7 January 2021

Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial

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7 January 2021

Effective combinatorial immunotherapy for castration-resistant prostate cancer

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7 January 2021

The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

1 reference

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7 January 2021

Setback for JAK2 inhibitors.

1 reference

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7 January 2021

Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma

1 reference

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7 January 2021

Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy.

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7 January 2021

Zoledronic-acid-induced circulating level modifications of angiogenic factors, metalloproteinases and proinflammatory cytokines in metastatic breast cancer patients

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7 January 2021

Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells

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7 January 2021

Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer

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7 January 2021

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity

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7 January 2021

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

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7 January 2021

Unopposed production of granulocyte-macrophage colony-stimulating factor by tumors inhibits CD8 T cell responses by dysregulating antigen-presenting cell maturation.

1 reference

12 December 2020

Pamidronate induces modifications of circulating angiogenetic factors in cancer patients.

1 reference

12 December 2020

Zoledronic acid induces significant and long-lasting modifications of circulating angiogenic factors in cancer patients.

1 reference

12 December 2020

Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review).

1 reference

12 December 2020

Blocking IDO activity to enhance anti-tumor immunity.

1 reference

12 December 2020

Signaling pathways involved in MDSC regulation

1 reference

12 December 2020

Myeloid Cell Origins, Differentiation, and Clinical Implications

1 reference

12 December 2020

10.1038/S41416-018-0333-1

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30413826 AND SRC:MED&resulttype=core&format=json

2 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30413826 AND SRC:MED&resulttype=core&format=json

2 May 2020

PubMed publication ID

30413826

1 reference