Common fragile site instability in normal cells: lessons and perspectives (Q58553471)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30387295 AND SRC:MED&resulttype=core&format=json

1 May 2020

title

Common fragile site instability in normal cells: Lessons and perspectives (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30387295 AND SRC:MED&resulttype=core&format=json

1 May 2020

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30387295 AND SRC:MED&resulttype=core&format=json

1 May 2020

Antonella Russo

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30387295 AND SRC:MED&resulttype=core&format=json

1 May 2020

author name string

Elisa Palumbo

series ordinal

1

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Antonella Russo

series ordinal

2

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language of work or name

English

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publication date

21 December 2018

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30387295 AND SRC:MED&resulttype=core&format=json

Genes, Chromosomes and Cancer

1 May 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30387295 AND SRC:MED&resulttype=core&format=json

1 May 2020

volume

58

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30387295 AND SRC:MED&resulttype=core&format=json

1 May 2020

issue

5

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1 May 2020

page(s)

260-269

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Fragile sites and predisposition to leukemia and lymphoma

1 May 2020

cites work

1 reference

7 January 2021

Common fragile sites associated with the breakpoints of chromosomal aberrations in hematologic neoplasms

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7 January 2021

Fragility Extraordinaire: Unsolved Mysteries of Chromosome Fragile Sites

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Chromosome fragile sites

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Human chromosome fragility

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How common are common fragile sites in humans: interindividual variation in the distribution of aphidicolin-induced fragile sites

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Molecular profiling of common fragile sites in human fibroblasts.

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Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes.

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Signatures of mutation and selection in the cancer genome

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Signatures of mutational processes in human cancer

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Identification of early replicating fragile sites that contribute to genome instability

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Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability

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FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells

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Early replication fragile sites: where replication-transcription collisions cause genetic instability.

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Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes

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Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication

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7 January 2021

The Detection and Analysis of Chromosome Fragile Sites.

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Cancer chromosome breakpoints and common fragile sites induced by aphidicolin

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DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes

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Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer

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Oncogenes create a unique landscape of fragile sites

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Oncogene-Induced Replication Stress Drives Genome Instability and Tumorigenesis.

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A selected group of large common fragile site genes have decreased expression in oropharyngeal squamous cell carcinomas.

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Very large common fragile site genes and their potential role in cancer development

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7 January 2021

Common fragile sites, extremely large genes, neural development and cancer

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Chromosomal fragile sites FRA3B and FRA16D show correlated expression and association with failure of apoptosis in lymphocytes from patients with thyroid cancer.

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7 January 2021

AnFHIT tumor suppressor gene?

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A functional copy number variation in the WWOX gene is associated with lung cancer risk in Chinese

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Comprehensive Analysis of Genome Rearrangements in Eight Human Malignant Tumor Tissues

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Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response

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7 January 2021

Fhit deficiency-induced global genome instability promotes mutation and clonal expansion

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7 January 2021

Fragile sites in cancer: more than meets the eye.

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7 January 2021

Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?

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7 January 2021

The effect of hydroxyurea on the expression of the common fragile site at 3p14

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7 January 2021

The complex basis underlying common fragile site instability in cancer

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7 January 2021

Molecular basis for expression of common and rare fragile sites

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7 January 2021

Secondary structure formation and DNA instability at fragile site FRA16B

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7 January 2021

Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction

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7 January 2021

Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability

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7 January 2021

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

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7 January 2021

Replication timing of two human common fragile sites: FRA1H and FRA2G.

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7 January 2021

The role of late/slow replication of the FRA16D in common fragile site induction

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7 January 2021

Replication dynamics at common fragile site FRA6E.

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7 January 2021

General and specific replication profiles are detected in normal human cells by genome-wide and single-locus molecular combing

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7 January 2021

The molecular basis of common and rare fragile sites

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7 January 2021

Failure of Origin Activation in Response to Fork Stalling Leads to Chromosomal Instability at Fragile Sites

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7 January 2021

Impaired replication dynamics at the FRA3B common fragile site

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7 January 2021

Peaks cloaked in the mist: the landscape of mammalian replication origins

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7 January 2021

Evidence for sequential and increasing activation of replication origins along replication timing gradients in the human genome

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7 January 2021

Sequencing newly replicated DNA reveals widespread plasticity in human replication timing

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7 January 2021

Global reorganization of replication domains during embryonic stem cell differentiation

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7 January 2021

Replication Domains: Genome Compartmentalization into Functional Replication Units.

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7 January 2021

Interplay between genetic and epigenetic factors governs common fragile site instability in cancer

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7 January 2021

Chromatin structure of human chromosomal fragile sites

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7 January 2021

Common fragile sites are characterized by histone hypoacetylation

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7 January 2021

Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions

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7 January 2021

Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes

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7 January 2021

Large transcription units unify copy number variants and common fragile sites arising under replication stress

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7 January 2021

Constitutive fragile sites and cancer.

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7 January 2021

Evolutionary breakpoints are co-localized with fragile sites and intrachromosomal telomeric sequences in primates.

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7 January 2021

Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes

1 reference

7 January 2021

Fragile sites in domestic animal chromosomes: molecular insights and challenges.

1 reference

7 January 2021

Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit

1 reference

7 January 2021

Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic

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7 January 2021

The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1

1 reference

7 January 2021

Identification of the human/mouse syntenic common fragile site FRA7K/Fra12C1--relation of FRA7K and other human common fragile sites on chromosome 7 to evolutionary breakpoints

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7 January 2021

Common fragile site tumor suppressor genes and corresponding mouse models of cancer

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7 January 2021

Initiation of genome instability and preneoplastic processes through loss of Fhit expression

1 reference

7 January 2021

The FHIT gene product: tumor suppressor and genome "caretaker"

1 reference

7 January 2021

Common fragile sites: Their prevalence in subjects with constitutional and acquired chromosomal instability

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7 January 2021

Fragile sites: overview, occurrence in acute nonlymphocytic leukemia and effects of caffeine on expression

1 reference

7 January 2021

Fibroblast-specific common fragile sites induced by aphidicolin

1 reference

7 January 2021

Mechanisms underlying structural variant formation in genomic disorders

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7 January 2021

Pan-cancer patterns of somatic copy number alteration

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7 January 2021

Chromosome Imbalances in Cancer: Molecular Cytogenetics Meets Genomics.

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7 January 2021

Copy number variants are produced in response to low-dose ionizing radiation in cultured cells

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7 January 2021

Genetic and epigenetic changes in clonal descendants of irradiated human fibroblasts

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7 January 2021

Acute High-Dose X-Radiation-Induced Genomic Changes in A549 Cells

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7 January 2021

Fhit and Wwox loss-associated genome instability: A genome caretaker one-two punch

1 reference

7 January 2021

Genetic instability of the tumor suppressor gene FHIT in normal human cells

1 reference

7 January 2021

The role of microhomology in genomic structural variation

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7 January 2021

Replication landscape of the human genome

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7 January 2021

Novel DNA damage checkpoint in mitosis: Mitotic DNA damage induces re-replication without cell division in various cancer cells

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7 January 2021

The genomic characteristics and cellular origin of chromothripsis.

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7 January 2021

Prevention of DNA re-replication in eukaryotic cells

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7 January 2021

Preventing re-replication of chromosomal DNA.

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7 January 2021

Loss of DNA Replication Control Is a Potent Inducer of Gene Amplification

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7 January 2021

Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry

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7 January 2021

Replication and re-replication: Different implications of the same mechanism

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7 January 2021

Replication stress activates DNA repair synthesis in mitosis.

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7 January 2021

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

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7 January 2021

Molecular cytogenetics of the micronucleus: Still surprising

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7 January 2021

The elusive evidence for chromothripsis

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7 January 2021

Fragile sites and chromosome breakpoints in constitutional rearrangements I. Amniocentesis

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7 January 2021

Fragile sites and chromosome breakpoints in constitutional rearrangements II. Spontaneous abortions, stillbirths and newborns

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7 January 2021

Analysis of eighteen deletion breakpoints in the parkin gene.

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7 January 2021

Mechanisms of genomic instabilities underlying two common fragile-site-associated loci, PARK2 and DMD, in germ cell and cancer cell lines

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7 January 2021

Genomic instability in the PARK2 locus is associated with Parkinson's disease

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7 January 2021

Characterizing complex structural variation in germline and somatic genomes

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7 January 2021

Structural mutations in cancer: mechanistic and functional insights

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7 January 2021

Meiotic recombination in mammals: localization and regulation

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7 January 2021

DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis

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7 January 2021

Mechanisms of germ line genome instability

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7 January 2021

Consequences of irradiation on adult spermatogenesis: Between infertility and hereditary risk

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7 January 2021

The measurement of induced genetic change in mammalian germ cells

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7 January 2021

High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome.

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7 January 2021

Rationally engineered Cas9 nucleases with improved specificity

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7 January 2021

Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX.

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7 January 2021

Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing

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7 January 2021

Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells

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7 January 2021

Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes

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7 January 2021

Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing

1 reference

7 January 2021

DNA Breaks and End Resection Measured Genome-wide by End Sequencing.

1 reference

7 January 2021

BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks

1 reference

7 January 2021

DNA break mapping reveals topoisomerase II activity genome-wide

1 reference

7 January 2021

Chromothripsis from DNA damage in micronuclei.

1 reference

7 January 2021

Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells

1 reference

7 January 2021

Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells

1 reference

7 January 2021

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

1 reference

7 January 2021

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases.

1 reference

7 January 2021

Identifiers

DOI

10.1002/GCC.22705

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30387295 AND SRC:MED&resulttype=core&format=json

1 May 2020

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