Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during infection (Q58091450)

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1 May 2020

title

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection (English)

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8

Stephen C Bunnell

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1 May 2020

author name string

Joseph Sarhan

1

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Beiyun C Liu

2

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1 May 2020

Hayley I Muendlein

3

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Peng Li

4

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Rachael Nilson

5

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Amy Y Tang

6

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Anthony Rongvaux

7

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Feng Shao

9

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Douglas R Green

10

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Alexander Poltorak

11

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language of work or name

English

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publication date

31 October 2018

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Proceedings of the National Academy of Sciences of the United States of America

1 May 2020

published in

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volume

115

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issue

46

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page(s)

E10888-E10897

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Constitutive synthesis of tumor necrosis factor in the thymus

1 May 2020

cites work

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12 December 2020

Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes

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12 December 2020

Yersiniasignals macrophages to undergo apoptosis and YopJ is necessary for this cell death

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12 December 2020

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

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12 December 2020

Etoposide: four decades of development of a topoisomerase II inhibitor

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12 December 2020

YopJ of Yersinia spp. is sufficient to cause downregulation of multiple mitogen-activated protein kinases in eukaryotic cells

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12 December 2020

TNF-R1 signaling: a beautiful pathway

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12 December 2020

Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition

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12 December 2020

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

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12 December 2020

Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis

1 reference

12 December 2020

Yersinia outer proteins: role in modulation of host cell signaling responses and pathogenesis

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12 December 2020

Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators

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12 December 2020

Essential function for the kinase TAK1 in innate and adaptive immune responses

1 reference

12 December 2020

Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response

1 reference

12 December 2020

Apoptosis: controlled demolition at the cellular level

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12 December 2020

Identification of RIP1 kinase as a specific cellular target of necrostatins

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12 December 2020

TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity

1 reference

12 December 2020

Pyroptosis: host cell death and inflammation

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12 December 2020

RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein

1 reference

12 December 2020

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

1 reference

12 December 2020

Constitutive type I interferon modulates homeostatic balance through tonic signaling

1 reference

12 December 2020

DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.

1 reference

12 December 2020

Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling

1 reference

12 December 2020

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol

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12 December 2020

The history of Toll-like receptors - redefining innate immunity.

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12 December 2020

Noncanonical inflammasome activation by intracellular LPS independent of TLR4.

1 reference

12 December 2020

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

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12 December 2020

Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.

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12 December 2020

Bacteria fighting back: how pathogens target and subvert the host innate immune system

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12 December 2020

Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling

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12 December 2020

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

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12 December 2020

RIP1/RIP3 binding to HSV-1 ICP6 initiates necroptosis to restrict virus propagation in mice.

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12 December 2020

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

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12 December 2020

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

1 reference

12 December 2020

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.

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12 December 2020

TAK1 inhibition-induced RIP1-dependent apoptosis in murine macrophages relies on constitutive TNF-α signaling and ROS production.

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12 December 2020

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

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12 December 2020

A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4

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12 December 2020

A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed

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12 December 2020

Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo

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12 December 2020

Programmed necrosis in inflammation: Toward identification of the effector molecules

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12 December 2020

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

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12 December 2020

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

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12 December 2020

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

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12 December 2020

Manipulation of interleukin-1β and interleukin-18 production by Yersinia pestis effectors YopJ and YopM and redundant impact on virulence.

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12 December 2020

Pore formation by GSDMD is the effector mechanism of pyroptosis

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12 December 2020

Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis

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12 December 2020

TAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpoints

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12 December 2020

Cell-Extrinsic TNF Collaborates with TRIF Signaling To Promote Yersinia-Induced Apoptosis

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12 December 2020

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

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12 December 2020

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

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12 December 2020

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

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12 December 2020

ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences

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12 December 2020

Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages.

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12 December 2020

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.

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12 December 2020

Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles.

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12 December 2020

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis.

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12 December 2020

RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense.

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12 December 2020

By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation

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12 December 2020

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation.

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1809548115

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1 May 2020

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1 May 2020

PubMed publication ID

30381458

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