Transferrin is responsible for mediating the effects of iron ions on the regulation of anterior pharynx-defective-1α/β and Presenilin 1 expression via PGE and PGD at the early stage of Alzheimer's Disease (Q58077633)

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scientific article published on 01 November 2018

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English	Transferrin is responsible for mediating the effects of iron ions on the regulation of anterior pharynx-defective-1α/β and Presenilin 1 expression via PGE and PGD at the early stage of Alzheimer's Disease	scientific article published on 01 November 2018

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1 May 2020

Transferrin is responsible for mediating the effects of iron ions on the regulation of anterior pharynx-defective-1α/β and Presenilin 1 expression via PGE2 and PGD2 at the early stage of Alzheimer's Disease (English)

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1 May 2020

Alzheimer's disease

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Chen-Di Lu

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Ji-Kang Ma

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1 May 2020

Zheng-Yang Luo

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Qun-Xi Tai

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Pu Wang

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Pei-Pei Guan

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1 November 2018

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1 May 2020

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3117-3135

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1 May 2020

Human transferrin polymorphism

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of iron in beta amyloid toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of iron uptake by mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transferrin C2 and Alzheimer's disease: another piece of the puzzle found?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in microtubule binding and self-association abilities of bovine brain tau isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood transferrin and ferritin in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous proteins controlling amyloid beta-peptide polymerization. Possible implications for beta-amyloid formation in the central nervous system and in peripheral tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox-active iron mediates amyloid-beta toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An iron-regulated ferric reductase associated with the absorption of dietary iron

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron homeostasis: insights from genetics and animal models

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pro-apoptotic signaling in neuronal cells following iron and amyloid beta peptide neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease; a clinico-pathologic analysis of twenty-three cases with a theory on pathogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metals accelerate production of the aberrant splicing isoform of the presenilin-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron and ageing: an introduction to iron regulatory mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transferrin neutralization of amyloid beta 25-35 cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary and genetically-induced oxidative stress alter tau phosphorylation: influence of folate and apolipoprotein E deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hematopoietic prostaglandin D synthase and DP1 receptor are selectively upregulated in microglia and astrocytes within senile plaques from human patients and in a mouse model of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deferoxamine synergistically enhances iron-mediated AP-1 activation: a showcase of the interplay between extracellular-signal-regulated kinase and tyrosine phosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of the prostaglandin E2 receptors EP subtypes in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular genetic approaches to understanding the roles and regulation of iron in brain health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A- and phosphatidylinositol 3-kinase-dependent NF-kappaB activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shear-induced interleukin-6 synthesis in chondrocytes: roles of E prostanoid (EP) 2 and EP3 in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-kappaB activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two to tango: regulation of Mammalian iron metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of transferrin expression by β‐amyloid through the CP2 transcription factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor-mediated abeta amyloid antibody targeting to Alzheimer's disease mouse brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of epidermal growth factor receptor signaling by the prostaglandin E(2) receptor EP4 pathway during gastric tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of hemochromatosis and transferrin gene mutations on iron dyshomeostasis, liver dysfunction and on the risk of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron(II) binding to amyloid-β, the Alzheimer's peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Δ(12,14)-PGJ2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Antagonistic Actions of Endogenous Interleukin-1β and 15-Deoxy-Δ12,14-prostaglandin J2 Regulate the Temporal Synthesis of Matrix Metalloproteinase-9 in Sheared Chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsomal prostaglandin E synthase-1 is induced in alzheimer's disease and its deletion mitigates alzheimer's disease-like pathology in a mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered APP Carboxyl-Terminal Processing Under Ferrous Iron Treatment in PC12 Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disaggregation of amyloid plaque in brain of Alzheimer's disease transgenic mice with daily subcutaneous administration of a tetravalent bispecific antibody that targets the transferrin receptor and the Abeta amyloid peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma nutrient status of patients with Alzheimer's disease: Systematic review and meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rosiglitazone prevents amyloid-β oligomer-induced impairment of synapse formation and plasticity via increasing dendrite and spine mitochondrial number

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of nuclear receptor on regulation of BDNF and neuroinflammation in hippocampus of β-amyloid animal model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggravation of Alzheimer's disease due to the COX-2-mediated reciprocal regulation of IL-1β and Aβ between glial and neuron cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pan-PPAR modulation effectively protects APP/PS1 mice from amyloid deposition and cognitive deficits

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biometals and their therapeutic implications in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related changes of brain iron load changes in the frontal cortex in APPswe/PS1ΔE9 transgenic mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

By suppressing the expression of anterior pharynx-defective-1α and -1β and inhibiting the aggregation of β-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Magnesium ion influx reduces neuroinflammation in Aβ precursor protein/Presenilin 1 transgenic mice by suppressing the expression of interleukin-1β.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin I₂ Attenuates Prostaglandin E₂-Stimulated Expression of Interferon γ in a β-Amyloid Protein- and NF-κB-Dependent Mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain biometals and Alzheimer's disease - boon or bane?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin I2 upregulates the expression of anterior pharynx-defective-1α and anterior pharynx-defective-1β in amyloid precursor protein/presenilin 1 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Role of Presenilin in Protein Trafficking and Degradation-Implications for Metal Homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ferroptosis, a Recent Defined Form of Critical Cell Death in Neurological Disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/30383537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.18632/AGING.101615

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1 May 2020

PMC publication ID

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1 May 2020

PubMed publication ID

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1 May 2020

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