Mutations in theINK4a/ARFMelanoma Susceptibility Locus Functionally Impair p14ARF (Q58024946)

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author name string

Artur P. Darmanian

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Elizabeth A. Holland

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Richard F. Kefford

Journal of Biological Chemistry

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language of work or name

English

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publication date

22 August 2001

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number of pages

11

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inferred from page(s)

published in

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volume

276

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issue

44

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page(s)

41424-41434

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https://api.crossref.org/works/10.1074/JBC.M105299200

Counseling and DNA testing for individuals perceived to be genetically predisposed to melanoma: A consensus statement of the Melanoma Genetics Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

p19ARF targets certain E2F species for degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Human ARF binds E2F1 and inhibits its transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Human ARF protein interacts with topoisomerase I and stimulates its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

E1A signaling to p53 involves the p19(ARF) tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

p19ARF links the tumour suppressor p53 to Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

p14ARF links the tumour suppressors RB and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Biologic and biochemical analyses of p16(INK4a) mutations from primary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Mutations associated with familial melanoma impair p16INK4 function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group [published erratum appears in Hum Mol Genet 1998 May;7(5):941]

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Germline p16 mutations in familial melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Germline Mutations of the CDKN2 Gene in UK Melanoma Families

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

CDKN2a/p16INK4a Mutations and Lack of p19ARF Involvement in Familial Melanoma Kindreds

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Mutational analysis of the CDKN2 gene in metastases from patients with cutaneous malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Differential expression of p16INK4a and p16beta transcripts in B-lymphoblastoid cells from members of hereditary melanoma families without CDKN2A exon mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

The INK4A/ARF locus and its two gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Functional reassessment of P16 variants using a transfection-based assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200

Tumor suppressor p16INK4A: structural characterization of wild-type and mutant proteins by NMR and circular dichroism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M105299200