Genetic and epigenetic analyses guided by high resolution whole-genome SNP array reveals a possible role of in Wilms tumour susceptibility (Q57821557)

1

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Beatrice Gamba

2

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Paola Corbetta

3

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Patrizia Mondini

4

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Monica Terenziani

5

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Serena Catania

6

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Marilina Nantron

7

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Maurizio Bianchi

8

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Paolo D'Angelo

9

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Federica Torri

10

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Fabio Macciardi

11

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Paola Collini

12

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Martina Di Martino

13

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Fraia Melchionda

14

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Andrea Di Cataldo

15

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Filippo Spreafico

16

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Daniela Perotti

A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor.

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language of work or name

English

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publication date

25 September 2018

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published in

Oncotarget

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volume

9

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issue

75

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page(s)

34079-34089

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cites work

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Chromosomal anomalies at 1q, 3, 16q, and mutations of SIX1 and DROSHA genes underlie Wilms tumor recurrences

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Multiple mechanisms of MYCN dysregulation in Wilms tumour

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Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors

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Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.

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CHEK2 (∗) 1100delC Mutation and Risk of Prostate Cancer

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Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours

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Stratification of Wilms tumor by genetic and epigenetic analysis

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Genomic profiling by whole-genome single nucleotide polymorphism arrays in Wilms tumor and association with relapse

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Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility

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Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene

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Rare, evolutionarily unlikely missense substitutions in CHEK2 contribute to breast cancer susceptibility: results from a breast cancer family registry case-control mutation-screening study

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Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor.

30 November 2018

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Constitutional translocation breakpoint mapping by genome-wide paired-end sequencing identifies HACE1 as a putative Wilms tumour susceptibility gene

30 November 2018

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Loss of heterozygosity at 2q37 in sporadic Wilms' tumor: putative role for miR-562.

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Classification of rare missense substitutions, using risk surfaces, with genetic- and molecular-epidemiology applications.

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Functional inactivation of the WTX gene is not a frequent event in Wilms' tumors

30 November 2018

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New prognostic markers revealed by evaluation of genes correlated with clinical parameters in Wilms tumors.

30 November 2018

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Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts

30 November 2018

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The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers

30 November 2018

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An X chromosome gene, WTX, is commonly inactivated in Wilms tumor

30 November 2018

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Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer

30 November 2018

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PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

30 November 2018

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Array comparative genomic hybridization reveals unbalanced gain of the MYCN region in Wilms tumors.

30 November 2018

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Rare germ line CHEK2 variants identified in breast cancer families encode proteins that show impaired activation

30 November 2018

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Expression profiling of Wilms tumors reveals new candidate genes for different clinical parameters

30 November 2018

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Alternative splicing and mutation status of CHEK2 in stage III breast cancer

30 November 2018

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Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney

30 November 2018

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Multigene methylation analysis of Wilms' tumour and adult renal cell carcinoma

30 November 2018

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Frequent RASSF1A tumour suppressor gene promoter methylation in Wilms' tumour and colorectal cancer

30 November 2018

1 reference

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Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status

30 November 2018

1 reference

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

30 November 2018

1 reference

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Enhanced expression of the N-myc gene in Wilms' tumors

30 November 2018

1 reference

12 December 2020

Decreased expression of the INK4 family of cyclin-dependent kinase inhibitors in Wilms tumor

1 reference

12 December 2020

Frequent overexpression of cyclin D2/cyclin-dependent kinase 4 in Wilms' tumor

1 reference

12 December 2020

Complex patterns of chromosome 9 alterations including the p16INK4a locus in Wilms tumours

1 reference

12 December 2020

Fanconi anemia gene mutations are not involved in sporadic Wilms tumor

1 reference

12 December 2020

Molecular profiling reveals frequent gain of MYCN and anaplasia-specific loss of 4q and 14q in wilms tumor

1 reference

12 December 2020