Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium (Q57786888)

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scientific article published on 01 November 2018

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English	Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium	scientific article published on 01 November 2018

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29 April 2020

Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium (English)

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29 April 2020

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drug interaction

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29 April 2020

Kathleen Giacomini

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29 April 2020

Yuichi Sugiyama

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29 April 2020

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Xiaoyan Chu

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29 April 2020

Mingxiang Liao

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29 April 2020

Hong Shen

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29 April 2020

Arik A Zur

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29 April 2020

Aleksandra Galetin

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29 April 2020

Imad Hanna

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29 April 2020

Hiroyuki Kusuhara

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29 April 2020

David Rodrigues

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29 April 2020

Maciej J Zamek-Gliszczynski

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29 April 2020

Lei Zhang

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29 April 2020

International Transporter Consortium

16

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29 April 2020

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1 November 2018

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29 April 2020

Clinical Pharmacology & Therapeutics

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29 April 2020

104

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29 April 2020

5

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29 April 2020

836-864

1 reference

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29 April 2020

Membrane transporters in drug development

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Transporter studies in drug development: experience to date and follow-up on decision trees from the International Transporter Consortium

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Evaluation of transporters in drug development: Current status and contemporary issues

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In Vitro-In Vivo Extrapolation of Metabolism- and Transporter-Mediated Drug-Drug Interactions-Overview of Basic Prediction Methods

1 reference

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ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans

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Clinical Drug-Drug Interaction Evaluations to Inform Drug Use and Enable Drug Access.

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In vitro methods to support transporter evaluation in drug discovery and development

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Identification of Endogenous Biomarkers to Predict the Propensity of Drug Candidates to Cause Hepatic or Renal Transporter-Mediated Drug-Drug Interactions

1 reference

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7 January 2021

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Endogenous Probes for Drug Transporters: Balancing Vision With Reality

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Biomarkers for In Vivo Assessment of Transporter Function.

1 reference

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7 January 2021

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Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective from the International Transporter Consortium.

1 reference

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7 January 2021

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International Transporter Consortium commentary on clinically important transporter polymorphisms.

1 reference

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7 January 2021

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The Use of Transporter Probe Drug Cocktails for the Assessment of Transporter-Based Drug-Drug Interactions in a Clinical Setting-Proposal of a Four Component Transporter Cocktail

1 reference

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Pharmacokinetic Evaluation of a Drug Transporter Cocktail Consisting of Digoxin, Furosemide, Metformin, and Rosuvastatin

1 reference

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Validation of a microdose probe drug cocktail for clinical drug interaction assessments for drug transporters and CYP3A.

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7 January 2021

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Predicting transporter-mediated drug interactions: Commentary on: "Pharmacokinetic evaluation of a drug transporter cocktail consisting of digoxin, furosemide, metformin and rosuvastatin" and "Validation of a microdose probe drug cocktail for clinic

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7 January 2021

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Evaluation of Proposed In Vivo Probe Substrates and Inhibitors for Phenotyping Transporter Activity in Humans

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7 January 2021

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Pitavastatin is a more sensitive and selective organic anion-transporting polypeptide 1B clinical probe than rosuvastatin

1 reference

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7 January 2021

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Understanding the critical disposition pathways of statins to assess drug-drug interaction risk during drug development: it's not just about OATP1B1.

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7 January 2021

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Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design.

1 reference

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7 January 2021

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SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid

1 reference

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Different Effects of SLCO1B1 Polymorphism on the Pharmacokinetics of Atorvastatin and Rosuvastatin

1 reference

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7 January 2021

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Identification of the rate-determining process in the hepatic clearance of atorvastatin in a clinical cassette microdosing study.

1 reference

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7 January 2021

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Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

1 reference

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7 January 2021

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OATP1B1 POLYMORPHISM IS A MAJOR DETERMINANT OF SERUM BILIRUBIN LEVEL BUT NOT ASSOCIATED WITH RIFAMPICIN-MEDIATED BILIRUBIN ELEVATION

1 reference

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7 January 2021

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Organic anion transporter 1B1: an important factor in hepatic thyroid hormone and estrogen transport and metabolism

1 reference

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7 January 2021

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Effect of SLCO1B1 polymorphism on the plasma concentrations of bile acids and bile acid synthesis marker in humans.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Genome-wide association meta-analysis for total serum bilirubin levels

1 reference

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7 January 2021

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Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1.

1 reference

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7 January 2021

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Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese Volunteers

1 reference

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7 January 2021

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Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs

1 reference

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7 January 2021

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Coproporphyrins I and III as Functional Markers of OATP1B Activity: In Vitro and In Vivo Evaluation in Preclinical Species

1 reference

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7 January 2021

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Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers

1 reference

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7 January 2021

based on heuristic

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Clinical Investigation of Coproporphyrins as Sensitive Biomarkers to Predict Mild to Strong OATP1B-Mediated Drug-Drug Interactions

1 reference

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7 January 2021

based on heuristic

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Coproporphyrins in Plasma and Urine Can Be Appropriate Clinical Biomarkers to Recapitulate Drug-Drug Interactions Mediated by Organic Anion Transporting Polypeptide Inhibition

1 reference

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7 January 2021

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Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects

1 reference

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7 January 2021

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Emerging Clinical Importance of Hepatic Organic Cation Transporter 1 (OCT1) in Drug Pharmacokinetics, Dynamics, Pharmacogenetic Variability, and Drug Interactions

1 reference

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7 January 2021

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ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision

1 reference

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7 January 2021

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Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance

1 reference

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7 January 2021

based on heuristic

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OCT1 mediates hepatic uptake of sumatriptan and loss-of-functionOCT1polymorphisms affect sumatriptan pharmacokinetics

1 reference

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7 January 2021

based on heuristic

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Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT3 antagonists tropisetron and ondansetron

1 reference

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7 January 2021

based on heuristic

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Increased Systemic Exposure and Stronger Cardiovascular and Metabolic Adverse Reactions to Fenoterol in Individuals with Heritable OCT1 Deficiency

1 reference

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7 January 2021

based on heuristic

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Genetically polymorphic OCT1: another piece in the puzzle of the variable pharmacokinetics and pharmacodynamics of the opioidergic drug tramadol

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Loss-of-function polymorphisms in the organic cation transporter OCT1 are associated with reduced postoperative tramadol consumption

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

OCT1 pharmacogenetics in pain management: is a clinical application within reach?

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Thiamin uptake by the human-derived renal epithelial (HEK-293) cells: cellular and molecular mechanisms

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Investigation of endogenous compounds for assessing the drug interactions in the urinary excretion involving multidrug and toxin extrusion proteins.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Human metabolic individuality in biomedical and pharmaceutical research

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibitory effects of p-aminohippurate and probenecid on the renal clearance of adefovir and benzylpenicillin as probe drugs for organic anion transporter (OAT) 1 and OAT3 in humans

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Investigation of Endogenous Compounds Applicable to Drug-Drug Interaction Studies Involving the Renal Organic Anion Transporters, OAT1 and OAT3, in Humans

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Evaluation of 6β-Hydroxycortisol, 6β-Hydroxycortisone, and a Combination of the Two as Endogenous Probes for Inhibition of CYP3A4 In Vivo

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

6β-Hydroxycortisol is an endogenous probe for evaluation of drug-drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in healthy subjects.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Transporters Involved in Metformin Pharmacokinetics and Treatment Response

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of the multidrug and toxin extrusion (MATE) transporter by pyrimethamine increases the plasma concentration of metformin but does not increase antihyperglycaemic activity in humans.

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Metformin pathways: pharmacokinetics and pharmacodynamics

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

N-methylnicotinamide is an endogenous probe for evaluation of drug-drug interactions involving multidrug and toxin extrusions (MATE1 and MATE2-K)

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

N(1)-methylnicotinamide as an endogenous probe for drug interactions by renal cation transporters: studies on the metformin-trimethoprim interaction.

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Pregnancy Increases the Renal Secretion of N1-methylnicotinamide, an Endogenous Probe for Renal Cation Transporters, in Patients Prescribed Metformin

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

System analysis in multiple dose kinetics: Evidence for saturable tubular reabsorption of the organic cationN 1-methylnicotinamide in humans

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The Complexities of Interpreting Reversible Elevated Serum Creatinine Levels in Drug Development: Does a Correlation with Inhibition of Renal Transporters Exist?

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Suitability of digoxin as a P-glycoprotein probe: implications of other transporters on sensitivity and specificity

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

ITC commentary on the prediction of digoxin clinical drug-drug interactions from in vitro transporter assays

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Concentration-dependent effect of naringin on intestinal absorption of beta(1)-adrenoceptor antagonist talinolol mediated by p-glycoprotein and organic anion transporting polypeptide (Oatp).

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Decrease in the oral bioavailability of dabigatran etexilate after co-medication with rifampicin.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Dabigatran Etexilate and Digoxin: Comparison as Clinical Probe Substrates for Evaluation of P-gp Inhibition

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

"Cocktail" approaches and strategies in drug development: valuable tool or flawed science?

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Safety and pharmacokinetics of the CIME combination of drugs and their metabolites after a single oral dosing in healthy volunteers.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Small-Dosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1 and ABCG2), and Interaction (Atorvastatin and Grapefruit Juice) Profiles of 5 Probes for OATP2B1 and BCRP.

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of Metformin and Furosemide on Rosuvastatin Pharmacokinetics in Healthy Volunteers: Implications for Their Use as Probe Drugs in a Transporter Cocktail

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Optimization of a drug transporter probe cocktail: potential screening tool for transporter-mediated drug-drug interactions.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Use of PET Imaging to Evaluate Transporter-Mediated Drug-Drug Interactions.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Intracellular drug concentrations and transporters: measurement, modeling, and implications for the liver

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The Role of the Kidney in Drug Elimination: Transport, Metabolism, and the Impact of Kidney Disease on Drug Clearance.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Gaining mechanistic insight into coproporphyrin I as endogenous biomarker for OATP1B-mediated drug-drug interactions using population pharmacokinetic modelling and simulation

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Short-term vitamin D receptor activation increases serum creatinine due to increased production with no effect on the glomerular filtration rate

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Short-term effects of vitamin D receptor activation on serum creatinine, creatinine generation, and glomerular filtration

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of the effect of multiple polymorphisms on the pharmacokinetics of simvastatin and simvastatin acid using a population-modeling approach

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Rifampin's acute inhibitory and chronic inductive drug interactions: experimental and model-based approaches to drug-drug interaction trial design.

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Oral bioavailability of dabigatran etexilate (Pradaxa(®) ) after co-medication with verapamil in healthy subjects

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of a single-dose rifampin on the pharmacokinetics of pitavastatin in healthy volunteers.

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Clarification of the Mechanism of Clopidogrel-Mediated Drug-Drug Interaction in a Clinical Cassette Small-dose Study and Its Prediction Based on In Vitro Information.

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions.

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Rifampicin alters atorvastatin plasma concentration on the basis of SLCO1B1 521T>C polymorphism

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Hydrophilic anti-migraine triptans are substrates for OATP1A2, a transporter expressed at human blood-brain barrier

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Sumatriptan: a review of its pharmacokinetics, pharmacodynamics and efficacy in the acute treatment of migraine

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Itraconazole Decreases Renal Clearance of Digoxin

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Evaluation of Ketoconazole and Its Alternative Clinical CYP3A4/5 Inhibitors as Inhibitors of Drug Transporters: The In Vitro Effects of Ketoconazole, Ritonavir, Clarithromycin, and Itraconazole on 13 Clinically-Relevant Drug Transporters

1 reference

https://api.crossref.org/works/10.1002/CPT.1216

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/CPT.1216

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30347454 AND SRC:MED&resulttype=core&format=json

29 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30347454 AND SRC:MED&resulttype=core&format=json

29 April 2020

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