Regulation of the initiation of DNA replication in human cells (Q57753011)

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25 April 2020

title

Regulation of the initiation of DNA replication in human cells (English)

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25 April 2020

1

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25 April 2020

author name string

Christopher J Bakkenist

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30266203 AND SRC:MED&resulttype=core&format=json

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language of work or name

English

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publication date

12 September 2018

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volume

72

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25 April 2020

page(s)

99-106

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Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15

25 April 2020

cites work

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12 December 2020

Inhibition of cyclin-dependent kinases by p21

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12 December 2020

Interactions of human nuclear proteins P1Mcm3 and P1Cdc46

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12 December 2020

Formation of p27-CDK complexes during the human mitotic cell cycle

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12 December 2020

Cell cycle regulation of the replication licensing system: involvement of a Cdk-dependent inhibitor

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12 December 2020

Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast

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12 December 2020

Spatial organization of large-scale chromatin domains in the nucleus: a magnified view of single chromosome territories.

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12 December 2020

Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells

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12 December 2020

Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase

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12 December 2020

Human minichromosome maintenance proteins and human origin recognition complex 2 protein on chromatin

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12 December 2020

Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription

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12 December 2020

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

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12 December 2020

Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6

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12 December 2020

A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication

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12 December 2020

Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication

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12 December 2020

Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts

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12 December 2020

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

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12 December 2020

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

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12 December 2020

Analysis of Cdc6 function in the assembly of mammalian prereplication complexes

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12 December 2020

Essential role of human CDT1 in DNA replication and chromatin licensing

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12 December 2020

Drf1, a novel regulatory subunit for human Cdc7 kinase

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12 December 2020

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

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12 December 2020

The ORC1 cycle in human cells: I. cell cycle-regulated oscillation of human ORC1.

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12 December 2020

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

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12 December 2020

Cdk2 knockout mice are viable

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12 December 2020

BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint

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12 December 2020

Cell cycle regulation of the licensing activity of Cdt1 in Xenopus laevis

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12 December 2020

Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region

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12 December 2020

Role for Cdk1 (Cdc2)/cyclin A in preventing the mammalian origin recognition complex's largest subunit (Orc1) from binding to chromatin during mitosis

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12 December 2020

Studies of the properties of human origin recognition complex and its Walker A motif mutants

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12 December 2020

A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases

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12 December 2020

Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells

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12 December 2020

Xenopus CDC7/DRF1 complex is required for the initiation of DNA replication

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12 December 2020

Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells

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12 December 2020

The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism

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12 December 2020

Identification of new human origins of DNA replication by an origin-trapping assay.

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12 December 2020

Cdc7 is an active kinase in human cancer cells undergoing replication stress.

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12 December 2020

How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A.

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12 December 2020

Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint

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12 December 2020

Cdc7-Dbf4 and the human S checkpoint response to UVC

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12 December 2020

Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition

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12 December 2020

Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways

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12 December 2020

Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication

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12 December 2020

Characterization of the interaction between the human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein

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12 December 2020

Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.

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12 December 2020

Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication.

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12 December 2020

Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase

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12 December 2020

Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells

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12 December 2020

The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control.

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12 December 2020

The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication

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12 December 2020

Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells.

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12 December 2020

Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins

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12 December 2020

The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation

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12 December 2020

Treslin collaborates with TopBP1 in triggering the initiation of DNA replication

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12 December 2020

Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion

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12 December 2020

HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin

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12 December 2020

CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast

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12 December 2020

GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication

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12 December 2020

Modeling genome-wide replication kinetics reveals a mechanism for regulation of replication timing

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12 December 2020

Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation

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12 December 2020

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories.

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12 December 2020

Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognition

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12 December 2020

Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication

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12 December 2020

Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation

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12 December 2020

Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans.

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12 December 2020

Studies on Human DNA Polymerase ϵ and GINS Complex and Their Role in DNA Replication

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12 December 2020

Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation

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12 December 2020

Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint

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12 December 2020

Topological domains in mammalian genomes identified by analysis of chromatin interactions

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12 December 2020

Rif1 regulates the replication timing domains on the human genome

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12 December 2020

Identification of a heteromeric complex that promotes DNA replication origin firing in human cells

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12 December 2020

The physical interaction of Mcm10 with Cdc45 modulates their DNA-binding properties

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12 December 2020

Principles and concepts of DNA replication in bacteria, archaea, and eukarya

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12 December 2020

ATR phosphorylates SMARCAL1 to prevent replication fork collapse

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12 December 2020

Multi-step loading of human minichromosome maintenance proteins in live human cells

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12 December 2020

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

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12 December 2020

A chromatin structure-based model accurately predicts DNA replication timing in human cells

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12 December 2020

The spatiotemporal program of DNA replication is associated with specific combinations of chromatin marks in human cells

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12 December 2020

Protein phosphatase 2A and Cdc7 kinase regulate the DNA unwinding element-binding protein in replication initiation

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12 December 2020

MCM Paradox: Abundance of Eukaryotic Replicative Helicases and Genomic Integrity.

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12 December 2020

Topologically associating domains are stable units of replication-timing regulation

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12 December 2020

Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication.

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12 December 2020

RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells

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12 December 2020

Regulated eukaryotic DNA replication origin firing with purified proteins

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12 December 2020

Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture

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12 December 2020

And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress

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12 December 2020

Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase

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12 December 2020

Synthetic lethality in chronic lymphocytic leukaemia with DNA damage response defects by targeting the ATR pathway

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12 December 2020

Replication timing is regulated by the number of MCMs loaded at origins

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12 December 2020

The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins

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12 December 2020

BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation

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12 December 2020

Replication landscape of the human genome

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12 December 2020

Cdc45 is limiting for replication initiation in humans

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12 December 2020

3D replicon distributions arise from stochastic initiation and domino-like DNA replication progression.

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12 December 2020

4D Visualization of replication foci in mammalian cells corresponding to individual replicons

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12 December 2020

A Role of hIPI3 in DNA Replication Licensing in Human Cells

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12 December 2020

A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells.

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12 December 2020

Chromosome Duplication in Saccharomyces cerevisiae.

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12 December 2020

Selectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers

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12 December 2020

TIMELESS Suppresses the Accumulation of Aberrant CDC45·MCM2-7·GINS Replicative Helicase Complexes on Human Chromatin

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12 December 2020

How MCM loading and spreading specify eukaryotic DNA replication initiation sites

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12 December 2020

H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication.

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12 December 2020

An Mcm10 Mutant Defective in ssDNA Binding Shows Defects in DNA Replication Initiation

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12 December 2020

Xenopus cell-free extracts and their contribution to the study of DNA replication and other complex biological processes

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12 December 2020

Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation.

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12 December 2020

Cdc45-induced loading of human RPA onto single-stranded DNA.

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12 December 2020

Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1.

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12 December 2020

Form and function of topologically associating genomic domains in budding yeast

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12 December 2020

Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability

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12 December 2020

The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing

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12 December 2020

Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication

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12 December 2020

Single-molecule visualization of Saccharomyces cerevisiae leading-strand synthesis reveals dynamic interaction between MTC and the replisome

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12 December 2020

ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1.

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12 December 2020

Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress

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12 December 2020

A mechanism for epigenetic control of DNA replication.

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12 December 2020

10.1016/J.DNAREP.2018.09.003

Identifiers

DOI

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25 April 2020

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25 April 2020

PubMed publication ID

30266203

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