Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias (Q57734345)

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English	Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias	article

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1 January 2020

Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias (English)

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1 January 2020

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acute myeloid leukemia

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childhood acute myeloid leukemia

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Charles G. Mullighan

1

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1 January 2020

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A Kennedy

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1 January 2020

X Zhou

3

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I Radtke

4

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L A Phillips

5

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S A Shurtleff

6

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J R Downing

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28 June 2007

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2000-2009

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1 January 2020

Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia

1 reference

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Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia

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Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia

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Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm.

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Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype

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Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations

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Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

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Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype

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Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance

1 reference

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Major nucleolar proteins shuttle between nucleus and cytoplasm

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ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway

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Nucleophosmin regulates the stability and transcriptional activity of p53

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Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

1 reference

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Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis

1 reference

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Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc AML.

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Gene expression profiling of pediatric acute myelogenous leukemia

1 reference

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Classification of pediatric acute lymphoblastic leukemia by gene expression profiling

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MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

1 reference

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Successive clinical trials for childhood acute myeloid leukemia at St Jude Children's Research Hospital, from 1980 to 2000.

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Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group

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A direct approach to false discovery rates

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Statistical significance for genomewide studies

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Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples

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The role of HOX genes in myeloid leukemogenesis

1 reference

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Hox regulation of normal and leukemic hematopoietic stem cells.

1 reference

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Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics

1 reference

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Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation

1 reference

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Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation

1 reference

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Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia

1 reference

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Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

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Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia

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HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo

1 reference

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Expression pattern of HOXB6 homeobox gene in myelomonocytic differentiation and acute myeloid leukemia.

1 reference

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Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: Impact on WHO classification

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Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo

1 reference

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HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.

1 reference

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Nucleophosmin and cancer

1 reference

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Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia

1 reference

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Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance

1 reference

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CEBPalpha mutations in childhood acute myeloid leukemia

1 reference

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Screening for MLL tandem duplication in 387 unselected patients with AML identify a prognostically unfavorable subset of AML

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404808

7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404808

7 January 2021

based on heuristic

inferred from DOI database lookup

NPM mutations in acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404808

7 January 2021

based on heuristic

inferred from DOI database lookup

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Nonparametric Estimation from Incomplete Observations

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404808

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1038/SJ.LEU.2404808

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17597811 AND SRC:MED&resulttype=core&format=json

1 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17597811 AND SRC:MED&resulttype=core&format=json

1 January 2020

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