Copper-induced structural propensities of the amyloidogenic region of human prion protein (Q57629342)

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14 March 2020

title

Copper-induced structural propensities of the amyloidogenic region of human prion protein (English)

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14 March 2020

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2

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14 March 2020

Henryk Kozłowski

3

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14 March 2020

author name string

Caterina Migliorini

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14 March 2020

Marek Luczkowski

4

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14 March 2020

Daniela Valensin

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14 March 2020

publication date

16 April 2014

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Journal of Biological Inorganic Chemistry

14 March 2020

published in

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volume

19

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issue

4-5

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page(s)

635-645

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The controversial protein-only hypothesis of prion propagation.

14 March 2020

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Molecular features of the copper binding sites in the octarepeat domain of the prion protein

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Copper binding to the octarepeats of the prion protein. Affinity, specificity, folding, and cooperativity: insights from circular dichroism

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The octarepeat domain of the prion protein binds Cu(II) with three distinct coordination modes at pH 7.4.

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The affinity of copper binding to the prion protein octarepeat domain: evidence for negative cooperativity

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Multiple forms of copper (II) co-ordination occur throughout the disordered N-terminal region of the prion protein at pH 7.4.

21 January 2018

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CuII binding sites located at His-96 and His-111 of the human prion protein: thermodynamic and spectroscopic studies on model peptides

21 January 2018

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Preferential Cu2 coordination by His96 and His111 induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein

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A reassessment of copper(II) binding in the full-length prion protein

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Fragment length influences affinity for Cu2 and Ni2 binding to His96 or His111 of the prion protein and spectroscopic evidence for a multiple histidine binding only at low pH.

21 January 2018

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Copper binding extrinsic to the octarepeat region in the prion protein

21 January 2018

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Copper coordination in the full-length, recombinant prion protein

21 January 2018

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Both Met(109) and Met(112) are utilized for Cu(II) coordination by the amyloidogenic fragment of the human prion protein at physiological pH.

21 January 2018

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Thermodynamic and spectroscopic investigation on the role of Met residues in Cu(II) binding to the non-octarepeat site of the human prion protein

21 January 2018

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A new method to determine the structure of the metal environment in metalloproteins: investigation of the prion protein octapeptide repeat Cu(2 ) complex.

21 January 2018

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Ab initio simulations of Cu binding sites on the N-terminal region of prion protein

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On the copper(II) ion coordination by prion protein HGGGW pentapeptide model.

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Computational studies of Cu(II)[peptide] binding motifs: Cu[HGGG] and Cu[HG] as models for Cu(II) binding to the prion protein octarepeat region

21 January 2018

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Molecular dynamics simulations of two tandem octarepeats from the mammalian prion protein: fully Cu2 -bound and metal-free forms

21 January 2018

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Modeling by assembly and molecular dynamics simulations of the low Cu2 occupancy form of the mammalian prion protein octarepeat region: gaining insight into Cu2 -mediated beta-cleavage

21 January 2018

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Structural effects of Cu(II)-coordination in the octapeptide region of the human prion protein

21 January 2018

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Molecular dynamics study of the Cu2 binding-induced "structuring" of the N-terminal domain of human prion protein

21 January 2018

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A potential mechanism for Cu2 reduction, beta-cleavage, and beta-sheet initiation within the N-terminal domain of the prion protein: insights from density functional theory and molecular dynamics calculations.

21 January 2018

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Can copper binding to the prion protein generate a misfolded form of the protein?

21 January 2018

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The hydrophobic core sequence modulates the neurotoxic and secondary structure properties of the prion peptide 106-126.

21 January 2018

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Molecular characteristics of a protease-resistant, amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein

21 January 2018

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21 January 2018

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21 January 2018

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Beta-sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange

21 January 2018

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Molecular architecture of human prion protein amyloid: a parallel, in-register beta-structure

21 January 2018

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From conversion to aggregation: protofibril formation of the prion protein

21 January 2018

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beta-sheet constitution of prion proteins

21 January 2018

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Structured pathway across the transition state for peptide folding revealed by molecular dynamics simulations

21 January 2018

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Molecular dynamics simulation of the unfolding of the human prion protein domain under low pH and high temperature conditions

21 January 2018

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Common Structural Traits across Pathogenic Mutants of the Human Prion Protein and Their Implications for Familial Prion Diseases

21 January 2018

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Copper reduction by copper binding proteins and its relation to neurodegenerative diseases

21 January 2018

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Role of copper in prion diseases: deleterious or beneficial?

21 January 2018

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Conformational plasticity of the Gerstmann-Sträussler-Scheinker disease peptide as indicated by its multiple aggregation pathways

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Structural and Dynamic Characterization of Copper(II) Binding of the Human Prion Protein Outside the Octarepeat Region

21 January 2018

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The complex-formation behaviour of His residues in the fifth Cu2 binding site of human prion protein: a close look

21 January 2018

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Structural Properties and Dynamic Behavior of Nonfibrillar Oligomers Formed by PrP(106−126)

21 January 2018

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The N-terminal tandem repeat region of human prion protein reduces copper: role of tryptophan residues

21 January 2018

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12 December 2020

Torsion angle dynamics for NMR structure calculation with the new program Dyana

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12 December 2020

Molecular dynamics simulations of Cu(II) and the PHGGGWGQ octapeptide

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12 December 2020

Spontaneous β-helical fold in prion protein: The case of PrP(82-146)

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12 December 2020

Copper(II) Interaction with Unstructured Prion Domain Outside the Octarepeat Region: Speciation, Stability, and Binding Details of Copper(II) Complexes with PrP106−126 Peptides

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12 December 2020

Examination of the secondary structure of proteins by deconvolved FTIR spectra

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12 December 2020

The cellular prion protein binds copper in vivo

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12 December 2020

Conformational polymorphism of the amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein

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12 December 2020

Copper(II) interaction with prion peptide fragments encompassing histidine residues within and outside the octarepeat domain: speciation, stability constants and binding details

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12 December 2020

The dimeric and tetrameric octarepeat fragments of prion protein behave differently to its monomeric unit

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12 December 2020

Prion proteins and copper ions. Biological and chemical controversies

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12 December 2020

Constant-pH Molecular Dynamics Simulations Reveal a β-Rich Form of the Human Prion Protein

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12 December 2020

Structural models for Cu(II) bound to the fragment 92-96 of the human prion protein

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12 December 2020

The copper(II) adduct of the unstructured region of the amyloidogenic fragment derived from the human prion protein is redox-active at physiological pH

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12 December 2020

Scrapie prion proteins are synthesized in neurons

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12 December 2020

The functional links between prion protein and copper

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12 December 2020

Spectroscopic and electronic structure studies of copper(II) binding to His111 in the human prion protein fragment 106-115: evaluating the role of protons and methionine residues

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12 December 2020

10.1007/S00775-014-1132-7

Identifiers

DOI

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14 March 2020

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