The tumor suppressor protein p53 stimulates the formation of the human topoisomerase I double cleavage complex in vitro (Q57566282)

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13 November 2019

title

The tumor suppressor protein p53 stimulates the formation of the human topoisomerase I double cleavage complex in vitro (English)

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13 November 2019

1

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13 November 2019

author name string

Hella Hartmann

2

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13 November 2019

Bernhard Schlott

3

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13 November 2019

Tinna Stevnsner

4

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13 November 2019

Frank Grosse

5

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13 November 2019

language of work or name

English

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publication date

1 September 2002

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13 November 2019

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13 November 2019

volume

21

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13 November 2019

issue

43

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13 November 2019

page(s)

6614-6623

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Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2

13 November 2019

cites work

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Nucleotide sequence of the bovine P53 tumor-suppressor cDNA.

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The p53 protein is an unusually shaped tetramer that binds directly to DNA.

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Effect of topoisomerase poisoning by antitumor drugs VM 26, fostriecin and camptothecin on DNA repair replication by mammalian cell extracts

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Modulation of DNA Topoisomerase I Activity byp53

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The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53

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Interaction between the N-terminus of human topoisomerase I and SV40 large T antigen

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Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein

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Covalent and noncovalent modifiers of the p53 protein

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Effect of specific enzyme inhibitors on replication, total genome DNA repair and on gene-specific DNA repair after UV irradiation in CHO cells

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Interaction between the N-terminal domain of human DNA topoisomerase I and the arginine-serine domain of its substrate determines phosphorylation of SF2/ASF splicing factor

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Cancer. p53, guardian of the genome

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p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

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Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status

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Twenty years of p53 research: structural and functional aspects of the p53 protein

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Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae

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Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes

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Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine

21 January 2018

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Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I.

21 January 2018

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Induction of topoisomerase I cleavage complexes by 1-beta -D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells

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Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA.

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Swiveling and decatenation of replicating simian virus 40 genomes in vivo

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A human topoisomerase I cleavage complex is recognized by an additional human topisomerase I molecule in vitro.

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Rapid induction of c-fos transcription reveals quantitative linkage of RNA polymerase II and DNA topoisomerase I enzyme activities

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The domain organization of human topoisomerase I

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p53 function and dysfunction

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p53 domains: identification and characterization of two autonomous DNA-binding regions.

21 January 2018

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Protein-protein interactions of the primase subunits p58 and p48 with simian virus 40 T antigen are required for efficient primer synthesis in a cell-free system

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A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

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Mapping of eukaryotic DNA topoisomerase I catalyzed cleavage without concomitant religation in the vicinity of DNA structural anomalies

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7 January 2021

Analysis of the binding of p53 to DNAs containing mismatched and bulged bases

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7 January 2021

Human DNA topoisomerase I-mediated cleavages stimulated by ultraviolet light-induced DNA damage

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7 January 2021

Alterations in the catalytic activity of yeast DNA topoisomerase I result in cell cycle arrest and cell death

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7 January 2021

Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps. Importance of DNA end phosphorylation and camptothecin effects

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Camptothecin-induced in vivo topoisomerase I cleavages in the transcriptionally active tyrosine aminotransferase gene

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7 January 2021

Various inhibitors of DNA topoisomerases diminish repair-specific DNA incision in UV-irradiated human fibroblasts

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205912

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12242659 AND SRC:MED&resulttype=core&format=json

13 November 2019

1 reference