The multifaceted role of autophagy in cancer and the microenvironment (Q57291210)

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27 April 2020

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The multifaceted role of autophagy in cancer and the microenvironment (English)

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27 April 2020

main subject

tumor microenvironment

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8 September 2020

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2 November 2020

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8 February 2021

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27 April 2020

author name string

Hendrik Folkerts

1

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27 April 2020

Susan Hilgendorf

2

1 reference

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27 April 2020

Edo Vellenga

3

1 reference

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27 April 2020

Edwin Bremer

4

1 reference

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27 April 2020

language of work or name

English

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publication date

9 October 2018

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Medicinal Research Reviews

27 April 2020

1 March 2019

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8 September 2020

2 November 2020

8 February 2021

4 references

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27 April 2020

8 September 2020

2 November 2020

8 February 2021

39

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issue

2

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page(s)

517-560

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Creative Commons Attribution

27 April 2020

copyright license

3 references

8 September 2020

2 November 2020

8 February 2021

0 references

Early loss of heterozygosity on 17q in ovarian cancer. The Abe Ovarian Cancer Genetics Group.

1 reference

12 December 2020

Factor XIIIa-mediated cross-linking of fibronectin in fibroblast cell layers. Cross-linking of cellular and plasma fibronectin and of amino-terminal fibronectin fragments

1 reference

12 December 2020

Loss of heterozygosity of the BRCA1 and other loci on chromosome 17q in human prostate cancer

1 reference

12 December 2020

Detailed deletion mapping of chromosome 17q in ovarian and breast cancers: 2-cM region on 17q21.3 often and commonly deleted in tumors

1 reference

12 December 2020

A protein conjugation system essential for autophagy

1 reference

12 December 2020

Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21

1 reference

12 December 2020

Induction of autophagy and inhibition of tumorigenesis by beclin 1

1 reference

12 December 2020

Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

1 reference

12 December 2020

The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3

1 reference

12 December 2020

Reversible inactivation of the tumor suppressor PTEN by H2O2

1 reference

12 December 2020

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

1 reference

12 December 2020

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

1 reference

12 December 2020

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

1 reference

12 December 2020

Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability

1 reference

12 December 2020

Autophagy as a cell death and tumor suppressor mechanism

1 reference

12 December 2020

The role of autophagy during the early neonatal starvation period

1 reference

12 December 2020

Enhanced anticryptococcal activity of chloroquine in phosphatidylserine-containing liposomes in a murine model.

1 reference

12 December 2020

Increased AF1q gene expression in high-risk myelodysplastic syndrome.

1 reference

12 December 2020

Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging

1 reference

12 December 2020

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

1 reference

12 December 2020

Autophagy promotes MHC class II presentation of peptides from intracellular source proteins

1 reference

12 December 2020

Cell intrinsic alterations underlie hematopoietic stem cell aging.

1 reference

12 December 2020

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

1 reference

12 December 2020

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

1 reference

12 December 2020

Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas

1 reference

12 December 2020

Autophagy is induced in CD4 T cells and important for the growth factor-withdrawal cell death

1 reference

12 December 2020

Calreticulin exposure dictates the immunogenicity of cancer cell death

1 reference

12 December 2020

A critical role for the autophagy gene Atg5 in T cell survival and proliferation

1 reference

12 December 2020

Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours

1 reference

12 December 2020

LAMP proteins are required for fusion of lysosomes with phagosomes

1 reference

12 December 2020

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

1 reference

12 December 2020

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

1 reference

12 December 2020

Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3

1 reference

12 December 2020

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

1 reference

12 December 2020

Autophagy suppresses tumor progression by limiting chromosomal instability

1 reference

12 December 2020

How shall I eat thee?

1 reference

12 December 2020

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

1 reference

12 December 2020

Ambra1 regulates autophagy and development of the nervous system

1 reference

12 December 2020

Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis

1 reference

12 December 2020

How to interpret LC3 immunoblotting

1 reference

12 December 2020

Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1

1 reference

12 December 2020

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

1 reference

12 December 2020

Establishing long-term cultures with self-renewing acute myeloid leukemia stem/progenitor cells.

1 reference

12 December 2020

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

1 reference

12 December 2020

Autophagy: process and function

1 reference

12 December 2020

Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: the contribution of autophagic cell death

1 reference

12 December 2020

Antibody-targeted liposomes in cancer therapy and imaging

1 reference

12 December 2020

Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice

1 reference

12 December 2020

A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells

1 reference

12 December 2020

Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells

1 reference

12 December 2020

Regulation of autophagy by cytoplasmic p53

1 reference

12 December 2020

Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability

1 reference

12 December 2020

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

1 reference

12 December 2020

Preparation and in vitro evaluation of liposomal chloroquine diphosphate loaded by a transmembrane pH-gradient method

1 reference

12 December 2020

Efficient cross-presentation depends on autophagy in tumor cells

1 reference

12 December 2020

Mutant p53 protein localized in the cytoplasm inhibits autophagy

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12 December 2020

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

1 reference

12 December 2020

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

1 reference

12 December 2020

Targeting antigen to MHC class II molecules promotes efficient cross-presentation and enhances immunotherapy

1 reference

12 December 2020

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

1 reference

12 December 2020

Monitoring autophagic degradation of p62/SQSTM1.

1 reference

12 December 2020

Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells

1 reference

12 December 2020

The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis.

1 reference

12 December 2020

Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains

1 reference

12 December 2020

Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes.

1 reference

12 December 2020

Ex vivo assays to study self-renewal and long-term expansion of genetically modified primary human acute myeloid leukemia stem cells.

1 reference

12 December 2020

Autophagy mediates the mitotic senescence transition

1 reference

12 December 2020

Autophagy is essential for mitochondrial clearance in mature T lymphocytes

1 reference

12 December 2020

Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL.

1 reference

12 December 2020

Presence of tumor-infiltrating lymphocytes is an independent prognostic factor in type I and II endometrial cancer

1 reference

12 December 2020

Stromal cell expression of caveolin-1 predicts outcome in breast cancer

1 reference

12 December 2020

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

1 reference

12 December 2020

Autophagy suppresses tumorigenesis through elimination of p62

1 reference

12 December 2020

Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia

1 reference

12 December 2020

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 reference

12 December 2020

Autophagy facilitates major histocompatibility complex class I expression induced by IFN-γ in B16 melanoma cells

1 reference

12 December 2020

FLIP-mediated autophagy regulation in cell death control

1 reference

12 December 2020

Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration

1 reference

12 December 2020

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

1 reference

12 December 2020

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

1 reference

12 December 2020

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

1 reference

12 December 2020

In vivo requirement for Atg5 in antigen presentation by dendritic cells

1 reference

12 December 2020

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

1 reference

12 December 2020

Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells

1 reference

12 December 2020

Reactive oxygen species in cancer

1 reference

12 December 2020

Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein

1 reference

12 December 2020

Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis

1 reference

12 December 2020

The epidermal growth factor receptor antibody cetuximab induces autophagy in cancer cells by downregulating HIF-1alpha and Bcl-2 and activating the beclin 1/hVps34 complex

1 reference

12 December 2020

FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells

1 reference

12 December 2020

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

1 reference

12 December 2020

Endogenous HMGB1 regulates autophagy

1 reference

12 December 2020

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

1 reference

12 December 2020

HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis

1 reference

12 December 2020

p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation.

1 reference

12 December 2020

Autophagy and the Integrated Stress Response

1 reference

12 December 2020

Macroautophagy regulates energy metabolism during effector T cell activation

1 reference

12 December 2020

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

1 reference

12 December 2020

MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner

1 reference

12 December 2020

Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis.

1 reference

12 December 2020

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

1 reference

12 December 2020

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.

1 reference

12 December 2020

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

1 reference

12 December 2020

Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival

1 reference

12 December 2020

Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy

1 reference

12 December 2020

Hallmarks of Cancer: The Next Generation

1 reference

12 December 2020

Temporal Regulation of Intracellular Organelle Homeostasis in T Lymphocytes by Autophagy

1 reference

12 December 2020

BH3 mimetics activate multiple pro-autophagic pathways

1 reference

12 December 2020

Autophagy-deficient mice develop multiple liver tumors

1 reference

12 December 2020

Decreased expression of Beclin-1 and LC3 in human lung cancer

1 reference

12 December 2020

Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis

1 reference

12 December 2020

Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

1 reference

12 December 2020

Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis

1 reference

12 December 2020

Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

1 reference

12 December 2020

PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment

1 reference

12 December 2020

Autophagy contributes to resistance of tumor cells to ionizing radiation

1 reference

12 December 2020

A photoconvertible fluorescent reporter to track chaperone-mediated autophagy

1 reference

12 December 2020

p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200.

1 reference

12 December 2020

Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression.

1 reference

12 December 2020

Tumor-Derived Autophagosome Vaccine: Induction of Cross-Protective Immune Responses against Short-lived Proteins through a p62-Dependent Mechanism

1 reference

12 December 2020

Autophagy impairment induces premature senescence in primary human fibroblasts.

1 reference

12 December 2020

Up-regulated autophagy by endogenous high mobility group box-1 promotes chemoresistance in leukemia cells.

1 reference

12 December 2020

High mobility group box 1 promotes endothelial cell angiogenic behavior in vitro and improves muscle perfusion in vivo in response to ischemic injury

1 reference

12 December 2020

Role of autophagy in angiogenesis in aortic endothelial cells

1 reference

12 December 2020

Breast cancer stem cells survive periods of farnesyl-transferase inhibitor-induced dormancy by undergoing autophagy

1 reference

12 December 2020

Tumor-Derived Autophagosome Vaccine: Mechanism of Cross-Presentation and Therapeutic Efficacy

1 reference

12 December 2020

Punctate LC3B Expression Is a Common Feature of Solid Tumors and Associated with Proliferation, Metastasis, and Poor Outcome

1 reference

12 December 2020

Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

1 reference

12 December 2020

Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice

1 reference

12 December 2020

Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance

1 reference

12 December 2020

A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells

1 reference

12 December 2020

The effect of the ATG16L1 Thr300Ala polymorphism on susceptibility and outcome of patients with epithelial cell-derived thyroid carcinoma

1 reference

12 December 2020

Major histocompatibility complex class i and tumour immuno-evasion: how to fool T cells and natural killer cells at one time

1 reference

12 December 2020

The blockade of immune checkpoints in cancer immunotherapy

1 reference

12 December 2020

Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma

1 reference

12 December 2020

Doxil®--the first FDA-approved nano-drug: lessons learned

1 reference

12 December 2020

A dual role for UVRAG in maintaining chromosomal stability independent of autophagy

1 reference

12 December 2020

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

1 reference

12 December 2020

Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis.

1 reference

12 December 2020

Doxorubicin and chloroquine coencapsulated liposomes: preparation and improved cytotoxicity on human breast cancer cells

1 reference

12 December 2020

Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB.

1 reference

12 December 2020

Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production

1 reference

12 December 2020

CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth.

1 reference

12 December 2020

Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1.

1 reference

12 December 2020

Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments

1 reference

12 December 2020

Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells

1 reference

12 December 2020

Autophagy mediates transporter associated with antigen processing-independent presentation of viral epitopes through MHC class I pathway

1 reference

12 December 2020

Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells

1 reference

12 December 2020

Chaperone-mediated autophagy: a unique way to enter the lysosome world

1 reference

12 December 2020

Autophagy restricts proliferation driven by oncogenic phosphatidylinositol 3-kinase in three-dimensional culture

1 reference

12 December 2020

Autophagic activity dictates the cellular response to oncogenic RAS.

1 reference

12 December 2020

A phase I study of erlotinib and hydroxychloroquine in advanced non-small-cell lung cancer

1 reference

12 December 2020

Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide

1 reference

12 December 2020

Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species

1 reference

12 December 2020

Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner

1 reference

12 December 2020

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis

1 reference

12 December 2020

Mitophagy: mechanisms, pathophysiological roles, and analysis

1 reference

12 December 2020

Th9 cells promote antitumor immune responses in vivo

1 reference

12 December 2020

Mitochondria and mitophagy: the yin and yang of cell death control

1 reference

12 December 2020

Targeting the MHC Class II antigen presentation pathway in cancer immunotherapy

1 reference

12 December 2020

The VMP1-Beclin 1 interaction regulates autophagy induction

1 reference

12 December 2020

Dissecting the role of the Atg12-Atg5-Atg16 complex during autophagosome formation

1 reference

12 December 2020

Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy

1 reference

12 December 2020

Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells.

1 reference

12 December 2020

Human mesenchymal stem cells enhance autophagy of lung carcinoma cells against apoptosis during serum deprivation

1 reference

12 December 2020

Epithelial-to-mesenchymal transition and autophagy induction in breast carcinoma promote escape from T-cell-mediated lysis.

1 reference

12 December 2020

Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34.

1 reference

12 December 2020

Reciprocal effects of rab7 deletion in activated and neglected T cells

1 reference

12 December 2020

Prognostic role of caveolin in breast cancer: a meta-analysis

1 reference

12 December 2020

Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells: role of autophagy and JNK activation

1 reference

12 December 2020

Enhancement of head and neck squamous cell carcinoma proliferation, invasion, and metastasis by tumor-associated fibroblasts in preclinical models

1 reference

12 December 2020

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

1 reference

12 December 2020

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

1 reference

12 December 2020

Chaperone-mediated autophagy degrades mutant p53.

1 reference

12 December 2020

MicroRNA 23b regulates autophagy associated with radioresistance of pancreatic cancer cells

1 reference

12 December 2020

Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells

1 reference

12 December 2020

EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance

1 reference

12 December 2020

Promoting colonization in metastatic HCC cells by modulation of autophagy

1 reference

12 December 2020

Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia

1 reference

12 December 2020

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

1 reference

12 December 2020

Chloroquine engages the immune system to eradicate irradiated breast tumors in mice

1 reference

12 December 2020

Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cells

1 reference

12 December 2020

Loss of iron triggers PINK1/Parkin-independent mitophagy

1 reference

12 December 2020

Analysis of a lung defect in autophagy-deficient mouse strains

1 reference

12 December 2020

p53 status determines the role of autophagy in pancreatic tumour development

1 reference

12 December 2020

Gap junction intercellular communications regulate NK cell activation and modulate NK cytotoxic capacity

1 reference

12 December 2020

T cell receptor-mediated activation is a potent inducer of macroautophagy in human CD8 CD28 T cells but not in CD8 CD28− T cells

1 reference

12 December 2020

Mutational landscape of the essential autophagy gene BECN1 in human cancers

1 reference

12 December 2020

Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways

1 reference

12 December 2020

Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.

1 reference

12 December 2020

Autophagy and cancer therapy

1 reference

12 December 2020

Boosting the MHC Class II-Restricted Tumor Antigen Presentation to CD4 T Helper Cells: A Critical Issue for Triggering Protective Immunity and Re-Orienting the Tumor Microenvironment Toward an Anti-Tumor State

1 reference

12 December 2020

Autophagy is a survival mechanism of acute myelogenous leukemia precursors during dual mTORC2/mTORC1 targeting

1 reference

12 December 2020

Cardiac glycoside ouabain induces autophagic cell death in non-small cell lung cancer cells via a JNK-dependent decrease of Bcl-2.

1 reference

12 December 2020

Phase I dose-escalation and -expansion study of buparlisib (BKM120), an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors

1 reference

12 December 2020

Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels

1 reference

12 December 2020

Determination of autophagy gene ATG16L1 polymorphism in human colorectal cancer

1 reference

12 December 2020

The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells.

1 reference

12 December 2020

Autophagy plays a protective role as an anti-oxidant system in human T cells and represents a novel strategy for induction of T-cell apoptosis.

1 reference

12 December 2020

Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells.

1 reference

12 December 2020

Phase II and pharmacodynamic study of autophagy inhibition using hydroxychloroquine in patients with metastatic pancreatic adenocarcinoma

1 reference

12 December 2020

Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells

1 reference

12 December 2020

The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells

1 reference

12 December 2020

Degradation of AF1Q by chaperone-mediated autophagy

1 reference

12 December 2020

Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells

1 reference

12 December 2020

Hydroxychloroquine inhibits autophagy to potentiate antiestrogen responsiveness in ER breast cancer.

1 reference

12 December 2020

ATG4B promotes colorectal cancer growth independent of autophagic flux.

1 reference

12 December 2020

Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma

1 reference

12 December 2020

Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors

1 reference

12 December 2020

Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma

1 reference

12 December 2020

Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

1 reference

12 December 2020

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

1 reference

12 December 2020

HMGB1-mediated autophagy promotes docetaxel resistance in human lung adenocarcinoma

1 reference

12 December 2020

Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy

1 reference

12 December 2020

Autophagy inhibition suppresses the tumorigenic potential of cancer stem cell enriched side population in bladder cancer

1 reference

12 December 2020

Dual inhibition of REV-ERBβ and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells

1 reference

12 December 2020

T-cell autophagy deficiency increases mortality and suppresses immune responses after sepsis

1 reference

12 December 2020

Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence.

1 reference

12 December 2020

Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation

1 reference

12 December 2020

ITPR1 protects renal cancer cells against natural killer cells by inducing autophagy

1 reference

12 December 2020

Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma

1 reference

12 December 2020

Autophagy is essential for effector CD8( ) T cell survival and memory formation

1 reference

12 December 2020

Autophagy is a critical regulator of memory CD8( ) T cell formation

1 reference

12 December 2020

Inhibition of MEK/ERK activation attenuates autophagy and potentiates pemetrexed-induced activity against HepG2 hepatocellular carcinoma cells

1 reference

12 December 2020

Modified vaccinia virus Ankara-infected dendritic cells present CD4 T-cell epitopes by endogenous major histocompatibility complex class II presentation pathways

1 reference

12 December 2020

Raloxifene induces autophagy-dependent cell death in breast cancer cells via the activation of AMP-activated protein kinase

1 reference

12 December 2020

Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors.

1 reference

12 December 2020

Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity

1 reference

12 December 2020

Th9 cells: a novel CD4 T-cell subset in the immune war against cancer.

1 reference

12 December 2020

A kinase-independent role for EGF receptor in autophagy initiation

1 reference

12 December 2020

The role for autophagy in cancer

1 reference

12 December 2020

NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells.

1 reference

12 December 2020

BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy

1 reference

12 December 2020

Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells

1 reference

12 December 2020

Inhibition of autophagy overcomes glucocorticoid resistance in lymphoid malignant cells

1 reference

12 December 2020

Survival of effector CD8 T cells during influenza infection is dependent on autophagy

1 reference

12 December 2020

Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy

1 reference

12 December 2020

Safety and Biologic Response of Pre-operative Autophagy Inhibition in Combination with Gemcitabine in Patients with Pancreatic Adenocarcinoma

1 reference

12 December 2020

SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL.

1 reference

12 December 2020

Differential use of autophagy by primary dendritic cells specialized in cross-presentation

1 reference

12 December 2020

Interference with HMGB1 increases the sensitivity to chemotherapy drugs by inhibiting HMGB1-mediated cell autophagy and inducing cell apoptosis

1 reference

12 December 2020

TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy

1 reference

12 December 2020

The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux

1 reference

12 December 2020

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates.

1 reference

12 December 2020

Hypoxia-induced autophagy mediates cisplatin resistance in lung cancer cells

1 reference

12 December 2020

Cross-cancer profiling of molecular alterations within the human autophagy interaction network

1 reference

12 December 2020

The Selective Degradation of Synaptic Connexin 43 Protein by Hypoxia-induced Autophagy Impairs Natural Killer Cell-mediated Tumor Cell Killing

1 reference

12 December 2020

Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells.

1 reference

12 December 2020

Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A.

1 reference

12 December 2020

Hypoxia-induced autophagy contributes to the invasion of salivary adenoid cystic carcinoma through the HIF-1α/BNIP3 signaling pathway

1 reference

12 December 2020

Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death

1 reference

12 December 2020

p53-regulated autophagy is controlled by glycolysis and determines cell fate

1 reference

12 December 2020

Genetic variants of the autophagy pathway as prognostic indicators for prostate cancer

1 reference

12 December 2020

Double autophagy modulators reduce 2-deoxyglucose uptake in sarcoma patients

1 reference

12 December 2020

Common γ-chain cytokine signaling is required for macroautophagy induction during CD4 T-cell activation

1 reference

12 December 2020

High mobility group box 1-mediated autophagy promotes neuroblastoma cell chemoresistance

1 reference

12 December 2020

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.

1 reference

12 December 2020

The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models

1 reference

12 December 2020

The roles of mitochondria in radiation-induced autophagic cell death in cervical cancer cells

1 reference

12 December 2020

Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia

1 reference

12 December 2020

Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1.

1 reference

12 December 2020

The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4 T Cells after Intercellular Antigen Transfer.

1 reference

12 December 2020

Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer

1 reference

12 December 2020

Gemcitabine and mitomycin induced autophagy regulates cancer stem cell pool in urothelial carcinoma cells

1 reference

12 December 2020

MicroRNA-30a downregulation contributes to chemoresistance of osteosarcoma cells through activating Beclin-1-mediated autophagy

1 reference

12 December 2020

Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway

1 reference

12 December 2020

The Role of HMGB1 in Radioresistance of Bladder Cancer

1 reference

12 December 2020

Autophagy maintains stemness by preventing senescence

1 reference

12 December 2020

Signaling through NOD-2 and TLR-4 Bolsters the T cell Priming Capability of Dendritic cells by Inducing Autophagy

1 reference

12 December 2020

The Warburg Effect: How Does it Benefit Cancer Cells?

1 reference

12 December 2020

The urgent need to recover MHC class I in cancers for effective immunotherapy

1 reference

12 December 2020

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

1 reference

12 December 2020

Heme oxygenase-1 contributes to imatinib resistance by promoting autophagy in chronic myeloid leukemia through disrupting the mTOR signaling pathway

1 reference

12 December 2020

Evidence That Does Not Support Pyruvate Kinase M2 (PKM2)-catalyzed Reaction as a Rate-limiting Step in Cancer Cell Glycolysis

1 reference

12 December 2020

Autophagy Proteins ATG5 and ATG7 Are Essential for the Maintenance of Human CD34( ) Hematopoietic Stem-Progenitor Cells

1 reference

12 December 2020

Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse

1 reference

12 December 2020

Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis

1 reference

12 December 2020

A role for ABCG2 beyond drug transport: Regulation of autophagy

1 reference

12 December 2020

Renal cell carcinoma escapes death by p53 depletion through transglutaminase 2-chaperoned autophagy

1 reference

12 December 2020

AMPK promotes tolerance to Ras pathway inhibition by activating autophagy

1 reference

12 December 2020

Autophagy protects ovarian cancer-associated fibroblasts against oxidative stress

1 reference

12 December 2020

Radiation induces autophagic cell death via the p53/DRAM signaling pathway in breast cancer cells

1 reference

12 December 2020

Radiation-induced autophagy promotes esophageal squamous cell carcinoma cell survival via the LKB1 pathway

1 reference

12 December 2020

Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8( ) T Cell Responses.

1 reference

12 December 2020

Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition.

1 reference

12 December 2020

How autophagy both activates and inhibits cellular senescence

1 reference

12 December 2020

Colorectal cancer cells are resistant to anti-EGFR monoclonal antibody through adapted autophagy

1 reference

12 December 2020

Proper autophagy is indispensable for angiogenesis during chick embryo development

1 reference

12 December 2020

U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3' End Formation.

1 reference

12 December 2020

Glimpse into the future: harnessing autophagy to promote anti-tumor immunity with the DRibbles vaccine

1 reference

12 December 2020

Sensitization of multidrug-resistant malignant cells by liposomes co-encapsulating doxorubicin and chloroquine through autophagic inhibition

1 reference

12 December 2020

Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia

1 reference

12 December 2020

Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors

1 reference

12 December 2020

Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias.

1 reference

12 December 2020

Codelivery of salinomycin and chloroquine by liposomes enables synergistic antitumor activity in vitro

1 reference

12 December 2020

Autophagy and Immune Senescence.

1 reference

12 December 2020

Critical Role for CD103( )/CD141( ) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

1 reference

12 December 2020

Cytoprotective autophagy maintains leukemia-initiating cells in murine myeloid leukemia.

1 reference

12 December 2020

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

1 reference

12 December 2020

Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation

1 reference

12 December 2020

miR-140-5p attenuates chemotherapeutic drug-induced cell death by regulating autophagy through inositol 1,4,5-trisphosphate kinase 2 (IP3k2) in human osteosarcoma cells

1 reference

12 December 2020

Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model

1 reference

12 December 2020

Suppression of T Cell Autophagy Results in Decreased Viability and Function of T Cells Through Accelerated Apoptosis in a Murine Sepsis Model

1 reference

12 December 2020

Tumor-released autophagosomes induce IL-10-producing B cells with suppressive activity on T lymphocytes via TLR2-MyD88-NF-κB signal pathway

1 reference

12 December 2020

Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma.

1 reference

12 December 2020

Buparlisib, a PI3K inhibitor, demonstrates acceptable tolerability and preliminary activity in a phase I trial of patients with advanced leukemias

1 reference

12 December 2020

Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons.

1 reference

12 December 2020

Complete mutational spectrum of the autophagy interactome: a novel class of tumor suppressor genes in myeloid neoplasms.

1 reference

12 December 2020

Autophagy Induction Results in Enhanced Anoikis Resistance in Models of Peritoneal Disease

1 reference

12 December 2020

Late-stage inhibition of autophagy enhances calreticulin surface exposure

1 reference

12 December 2020

Oxidative stress induced autophagy in cancer associated fibroblast enhances proliferation and metabolism of colorectal cancer cells

1 reference

12 December 2020

AMPK-ULK1-Mediated Autophagy Confers Resistance to BET Inhibitor JQ1 in Acute Myeloid Leukemia Stem Cells

1 reference

12 December 2020

Pyruvate kinase M2 (PKM2) expression correlates with prognosis in solid cancers: a meta-analysis

1 reference

12 December 2020

Inhibiting the cytoplasmic location of HMGB1 reverses cisplatin resistance in human cervical cancer cells

1 reference

12 December 2020

Targeting AMPK-ULK1-mediated autophagy for combating BET inhibitor resistance in acute myeloid leukemia stem cells.

1 reference

12 December 2020

P53 mutations and cancer: a tight linkage.

1 reference

12 December 2020

Chloroquine inhibits human CD4 T-cell activation by AP-1 signaling modulation.

1 reference

12 December 2020

Autophagy, Metabolism, and Cancer

1 reference

12 December 2020

Autophagy maintains the metabolism and function of young and old stem cells.

1 reference

12 December 2020

Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through Autophagy.

1 reference

12 December 2020

Antibody-Based Cancer Therapy: Successful Agents and Novel Approaches

1 reference

12 December 2020

Identification and validation of a novel autophagy gene expression signature for human bladder cancer patients.

1 reference

12 December 2020

Double autophagy stimulation using chemotherapy and mTOR inhibition combined with hydroxychloroquine for autophagy modulation in patients with relapsed or refractory multiple myeloma.

1 reference

12 December 2020

Downregulation of miR-429 contributes to the development of drug resistance in epithelial ovarian cancer by targeting ZEB1.

1 reference

12 December 2020

A blockade of PD-L1 produced antitumor and antimetastatic effects in an orthotopic mouse pancreatic cancer model via the PI3K/Akt/mTOR signaling pathway

1 reference

12 December 2020

Targeting autophagic cancer stem-cells to reverse chemoresistance in human triple negative breast cancer

1 reference

12 December 2020

Genetically engineered mesenchymal stromal cells produce IL-3 and TPO to further improve human scaffold-based xenograft models

1 reference

12 December 2020

SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways.

1 reference

12 December 2020

A microfluidic chip for screening individual cancer cells via eavesdropping on autophagy-inducing crosstalk in the stroma niche.

1 reference

12 December 2020

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

1 reference

12 December 2020

Effective-Loading of Platinum-Chloroquine into PEGylated Neutral and Cationic Liposomes as a Drug Delivery System for Resistant Malaria Parasites

1 reference

12 December 2020

Silencing of BAG3 promotes the sensitivity of ovarian cancer cells to cisplatin via inhibition of autophagy

1 reference

12 December 2020

Inhibition of autophagy as a treatment strategy for p53 wild-type acute myeloid leukemia

1 reference

12 December 2020

1 reference

12 December 2020

Autophagy inhibition improves sunitinib efficacy in pancreatic neuroendocrine tumors via a lysosome-dependent mechanism.

1 reference

12 December 2020

Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A.

1 reference

12 December 2020

Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells

1 reference

12 December 2020

Autophagy Is Pro-Senescence When Seen in Close-Up, but Anti-Senescence in Long-Shot

1 reference

12 December 2020

Anti-proliferation of triple-negative breast cancer cells with physagulide P: ROS/JNK signaling pathway induces apoptosis and autophagic cell death

1 reference

12 December 2020

Secretory Autophagy in Cancer-Associated Fibroblasts Promotes Head and Neck Cancer Progression and Offers a Novel Therapeutic Target

1 reference

12 December 2020

Regulation of Glycolytic Metabolism by Autophagy in Liver Cancer Involves Selective Autophagic Degradation of HK2 (hexokinase 2).

1 reference

12 December 2020

Oncogenic FLT3-ITD supports autophagy via ATF4 in acute myeloid leukemia

1 reference

12 December 2020

MicroRNA-30a suppresses autophagy-mediated anoikis resistance and metastasis in hepatocellular carcinoma

1 reference

12 December 2020

HMGB1-mediated autophagy confers resistance to gemcitabine in hormone-independent prostate cancer cells

1 reference

12 December 2020

ABC Transporters in Cancer Stem Cells: Beyond Chemoresistance.

1 reference

12 December 2020

Autophagy regulates cisplatin-induced stemness and chemoresistance via the upregulation of CD44, ABCB1 and ADAM17 in oral squamous cell carcinoma

1 reference

12 December 2020

Prognostic value of tumor-infiltrating Foxp3 regulatory T cells in patients with breast cancer: a meta-analysis

1 reference

12 December 2020

Inhibition of autophagy enhances synergistic effects of Salidroside and anti-tumor agents against colorectal cancer

1 reference

12 December 2020

Clinical Implications of the Autophagy Core Gene Variations in Advanced Lung Adenocarcinoma Treated with Gefitinib

1 reference

12 December 2020

FREQUENT SUBCLINICAL MACULAR CHANGES IN COMBINED BRAF/MEK INHIBITION WITH HIGH-DOSE HYDROXYCHLOROQUINE AS TREATMENT FOR ADVANCED METASTATIC BRAF MUTANT MELANOMA: Preliminary Results From a Phase I/II Clinical Treatment Trial

1 reference

12 December 2020

Lup-20(29)-en-3β,28-di-yl-nitrooxy acetate affects MCF-7 proliferation through the crosstalk between apoptosis and autophagy in mitochondria.

1 reference

12 December 2020

F1012-2 inhibits the growth of triple negative breast cancer through induction of cell cycle arrest, apoptosis, and autophagy.

1 reference

12 December 2020

Inhibition of autophagy enhances DENSpm-induced apoptosis in human colon cancer cells in a p53 independent manner

1 reference

12 December 2020

Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover.

1 reference

12 December 2020

High Throughput Screens to Identify Autophagy Inducers that Function by Disrupting Beclin 1/Bcl-2 Binding.

1 reference

12 December 2020

Identifiers

DOI

10.1002/MED.21531

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30302772 AND SRC:MED&resulttype=core&format=json

27 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30302772 AND SRC:MED&resulttype=core&format=json

27 April 2020

PubMed publication ID

30302772

1 reference