Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL (Q57279753)

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scientific article published on 11 October 2018

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English	Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL	scientific article published on 11 October 2018

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27 April 2020

Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL (English)

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Alex J. Eustace

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Radosław Zagożdżon

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Ronald William Watson

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Martina S J McDermott

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Brigid C Browne

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Frankie A Holmes

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Clair Gallagher

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Lorraine O'Driscoll

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Stephen F Madden

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Neil A O'Brien

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Charles Ginther

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Dennis Slamon

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Naomi Walsh

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William M Gallagher

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Norma O'Donovan

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John Crown

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11 October 2018

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limma

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Europe PubMed Central

22 June 2022

https://europepmc.org/article/PMC/6180577

based on heuristic

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CZ Software Mentions: A large dataset of software mentions in the biomedical literature

Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2.

1 reference

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12 December 2020

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Suppression of Akt signaling induces Fas ligand expression: involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation

1 reference

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.

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PI3K mediates protection against TRAIL-induced apoptosis in primary human melanocytes

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Forkhead box transcription factor FOXO3a regulates estrogen receptor alpha expression and is repressed by the Her-2/neu/phosphatidylinositol 3-kinase/Akt signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/30305055

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TRAIL-induced apoptosis in gliomas is enhanced by Akt-inhibition and is independent of JNK activation

1 reference

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12 December 2020

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HER2 signaling downregulation by trastuzumab and suppression of the PI3K/Akt pathway: an unexpected effect on TRAIL-induced apoptosis.

1 reference

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12 December 2020

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Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30305055

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1 reference

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Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells

1 reference

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1 reference

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Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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