Role of the growth hormone–IGF-1 axis in cancer (Q57252658)

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23 April 2020

title

Role of the growth hormone-IGF-1 axis in cancer (English)

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23 April 2020

1

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23 April 2020

Andrew J. Brooks

series ordinal

3

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23 April 2020

author name string

Michael J Waters

series ordinal

2

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23 April 2020

publication date

1 January 2011

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Expert review of endocrinology & metabolism

23 April 2020

published in

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23 April 2020

volume

6

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issue

1

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23 April 2020

page(s)

71-84

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Normal growth and development in the absence of hepatic insulin-like growth factor I

23 April 2020

cites work

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Does growth hormone cause cancer?

21 January 2018

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The role of the IGF system in cancer growth and metastasis: overview and recent insights

21 January 2018

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The Hallmarks of Cancer

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Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3.

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The question of a link between insulin-like growth factor physiology and neoplasia

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The GH-IGF-I axis and breast cancer.

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Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

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Mechanistic aspects of crosstalk between GH and PRL and ErbB receptor family signaling

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Growth hormone receptor; mechanism of action.

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Height, leg length, and cancer risk: a systematic review

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Serum and intratumoural GH and IGF-I concentrations: prognostic factors in the outcome of canine mammary cancer.

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Co-twin control and cohort analyses of body mass index and height in relation to breast, prostate, ovarian, corpus uteri, colon and rectal cancer among Swedish and Finnish twins

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21 January 2018

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Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells: new insights into their synergistic effects

21 January 2018

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Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions

21 January 2018

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Variants in the GH-IGF axis confer susceptibility to lung cancer

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Pathway analysis of breast cancer genome-wide association study highlights three pathways and one canonical signaling cascade

21 January 2018

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Genetic Variation in the Growth Hormone Synthesis Pathway in Relation to Circulating Insulin-Like Growth Factor-I, Insulin-Like Growth Factor Binding Protein-3, and Breast Cancer Risk: Results from the European Prospective Investigation into Cancer a

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Influence of IGFBP3 gene polymorphisms on IGFBP3 serum levels and the risk of prostate cancer in low-risk Korean men.

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Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer

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Acromegaly, growth hormone and cancer risk

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Acromegaly: re-thinking the cancer risk

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The association of fasting insulin concentrations and colonic neoplasms in acromegaly: a colonoscopy-based study in 210 patients

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Long-term safety of recombinant human growth hormone in children

21 January 2018

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High frequency of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice created from two different strains of mice

21 January 2018

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Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

21 January 2018

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Overexpressed growth hormone (GH) synergistically promotes carcinogen-initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice.

21 January 2018

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Transgenic mice overexpressing GH exhibit hepatic upregulation of GH-signaling mediators involved in cell proliferation

21 January 2018

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Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor

21 January 2018

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Suppressor of cytokine signaling-2 limits intestinal growth and enterotrophic actions of IGF-I in vivo

21 January 2018

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Inhibition of estrogen-independent mammary carcinogenesis by disruption of growth hormone signaling

21 January 2018

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Mammary tumorigenesis in growth hormone deficient spontaneous dwarf rats; effects of hormonal treatments

21 January 2018

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Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C3(1)/T antigen mouse

21 January 2018

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Reduced mammary gland carcinogenesis in transgenic mice expressing a growth hormone antagonist

21 January 2018

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The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth

21 January 2018

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Antitumor activity of the growth hormone receptor antagonist pegvisomant against human meningiomas in nude mice

21 January 2018

1 reference

Paracrine overexpression of insulin-like growth factor-1 enhances mammary tumorigenesis in vivo

21 January 2018

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Genetic reduction of circulating insulin-like growth factor-1 inhibits azoxymethane-induced colon tumorigenesis in mice

21 January 2018

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Growth hormone receptor is expressed in human breast cancer

21 January 2018

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Control of growth hormone (GH) binding protein release from human hepatoma cells expressing full-length GH receptor

21 January 2018

1 reference

Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer

21 January 2018

1 reference

Growth hormone (GH) receptors in prostate cancer: gene expression in human tissues and cell lines and characterization, GH signaling and androgen receptor regulation in LNCaP cells

21 January 2018

1 reference

Growth hormone mRNA in mammary gland tumors of dogs and cats

21 January 2018

1 reference

Crosstalk between GH/IGF-I axis and steroid hormones (progesterone, 17beta-estradiol) in canine mammary tumours.

21 January 2018

1 reference

Integrated gene networks in breast cancer development

21 January 2018

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Morphogenic and tumorigenic potentials of the mammary growth hormone/growth hormone receptor system

21 January 2018

1 reference

Pit-1/GHF-1 and GH expression in the MCF-7 human breast adenocarcinoma cell line

21 January 2018

1 reference

Co-expression of GH and GHR isoforms in prostate cancer cell lines

21 January 2018

1 reference

Effect of growth hormone (GH) and/or testosterone replacement on the prostate in GH-deficient adult patients

21 January 2018

1 reference

Effects of high-dose IFNalpha2b on regional lymph node metastases of human melanoma: modulation of STAT5, FOXP3, and IL-17.

21 January 2018

1 reference

Evidence that insulin-like growth factor I and growth hormone are required for prostate gland development

21 January 2018

1 reference

Zinc mediation of the binding of human growth hormone to the human prolactin receptor

21 January 2018

1 reference

Gene expression profiling to identify oncogenic determinants of autocrine human growth hormone in human mammary carcinoma.

21 January 2018

1 reference

The contribution of growth hormone to mammary neoplasia

21 January 2018

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Autocrine human growth hormone promotes tumor angiogenesis in mammary carcinoma

21 January 2018

1 reference

The effects of autocrine human growth hormone (hGH) on human mammary carcinoma cell behavior are mediated via the hGH receptor

21 January 2018

1 reference

Autocrine growth hormone: effects on growth hormone receptor trafficking and signaling

21 January 2018

1 reference

Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis.

21 January 2018

1 reference

Increased nuclear expression of growth hormone receptor in uterine cervical neoplasms of women under 40 years old.

21 January 2018

1 reference

Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival.

21 January 2018

1 reference

The extracellular domain of the growth hormone receptor interacts with coactivator activator to promote cell proliferation

21 January 2018

1 reference

Gene amplification and associated loss of 5' regulatory sequences of CoAA in human cancers

21 January 2018

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Co-activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors

21 January 2018

1 reference

CoAA, a nuclear receptor coactivator protein at the interface of transcriptional coactivation and RNA splicing

21 January 2018

1 reference

Prolactin does not require insulin-like growth factor intermediates but synergizes with insulin-like growth factor I in human breast cancer cells

21 January 2018

1 reference

Complex prolactin crosstalk in breast cancer: new therapeutic implications

21 January 2018

1 reference

Activation of the prolactin receptor but not the growth hormone receptor is important for induction of mammary tumors in transgenic mice.

21 January 2018

1 reference

Autocrine prolactin promotes prostate cancer cell growth via Janus kinase-2-signal transducer and activator of transcription-5a/b signaling pathway

21 January 2018

1 reference

Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors

21 January 2018

1 reference

Transcriptional activation of signal transducer and activator of transcription (STAT) 3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell.

21 January 2018

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Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior.

21 January 2018

1 reference

STAT3alpha is oncogenic for endometrial carcinoma cells and mediates the oncogenic effects of autocrine human growth hormone.

21 January 2018

1 reference

JAK-2 mutations and their relevance to myeloproliferative disease

21 January 2018

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A role for JAK2 mutations in myeloproliferative diseases

21 January 2018

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A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

21 January 2018

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Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl

21 January 2018

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MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

21 January 2018

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STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant

21 January 2018

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Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia

21 January 2018

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Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.

21 January 2018

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STAT5 phosphorylation in malignant melanoma is important for survival and is mediated through SRC and JAK1 kinases

21 January 2018

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STAT5 contributes to antiapoptosis in melanoma.

21 January 2018

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Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition.

21 January 2018

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Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression

21 January 2018

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Constitutive activation of signal transducer and activator of transcription 5 contributes to tumor growth, epithelial-mesenchymal transition, and resistance to epidermal growth factor receptor targeting

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21 January 2018

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21 January 2018

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A mutated EGFR is sufficient to induce malignant melanoma with genetic background-dependent histopathologies.

21 January 2018

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Small-molecule cyclin-dependent kinase modulators

21 January 2018

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Inhibition of transcription factor Stat5 induces cell death of human prostate cancer cells

21 January 2018

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Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo

21 January 2018

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Mammary stem cell number as a determinate of breast cancer risk.

21 January 2018

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Naturally occurring dominant-negative Stat5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells

21 January 2018

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MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients

21 January 2018

1 reference

Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin

21 January 2018

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New concepts in prolactin biology

21 January 2018

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Growth hormone protects human lymphocytes from irradiation‐induced cell death

21 January 2018

1 reference

Growth hormone excess promotes breast cancer chemoresistance

21 January 2018

1 reference

Exercise increases neural stem cell number in a growth hormone-dependent manner, augmenting the regenerative response in aged mice

21 January 2018

1 reference

IGF-I andIGFBP-3 polymorphisms and risk of prostate cancer

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/EEM.10.73

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30764037 AND SRC:MED&resulttype=core&format=json

23 April 2020

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