Cancer immunotherapy based on mutation-specific CD4 T cells in a patient with epithelial cancer (Q57152489)

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17 March 2020

title

Cancer immunotherapy based on mutation-specific CD4 T cells in a patient with epithelial cancer (English)

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17 March 2020

1 reference

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3

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17 March 2020

Yong-Chen Lu

5

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17 March 2020

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Steven A Rosenberg

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17 March 2020

author name string

Eric Tran

1

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17 March 2020

Simon Turcotte

2

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17 March 2020

Paul F Robbins

4

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17 March 2020

Mark E Dudley

6

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17 March 2020

John R Wunderlich

7

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17 March 2020

Robert P Somerville

8

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17 March 2020

Katherine Hogan

9

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17 March 2020

Christian S Hinrichs

10

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17 March 2020

Maria R Parkhurst

11

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17 March 2020

James C Yang

12

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17 March 2020

language of work or name

English

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publication date

1 May 2014

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17 March 2020

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17 March 2020

volume

344

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17 March 2020

issue

6184

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17 March 2020

page(s)

641-645

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17 March 2020

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Antigen Spreading Contributes to MAGE Vaccination-Induced Regression of Melanoma Metastases

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T cells associated with tumor regression recognize frameshifted products of the CDKN2A tumor suppressor gene locus and a mutated HLA class I gene product

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Long-term follow-up of patients with resected pancreatic cancer following vaccination against mutant K-ras

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CD4( ) T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma

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Primary antitumor immune response mediated by CD4 T cells

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Tumor-reactive CD4( ) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

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Naive tumor-specific CD4( ) T cells differentiated in vivo eradicate established melanoma.

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Therapy of disseminated murine leukemia with cyclophosphamide and immune Lyt-1 ,2- T cells. Tumor eradication does not require participation of cytotoxic T cells

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Polyfunctional CD4⁺ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy

21 January 2018

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Immunity to murine prostatic tumors: continuous provision of T-cell help prevents CD8 T-cell tolerance and activates tumor-infiltrating dendritic cells

21 January 2018

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Treatment of metastatic melanoma with autologous CD4 T cells against NY-ESO-1

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T-helper-1-cell cytokines drive cancer into senescence

21 January 2018

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CD4 T cell--mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cells.

21 January 2018

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CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit

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Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy

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Phenotype and function of T cells infiltrating visceral metastases from gastrointestinal cancers and melanoma: implications for adoptive cell transfer therapy

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Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma

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Simplified method of the growth of human tumor infiltrating lymphocytes in gas-permeable flasks to numbers needed for patient treatment

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High frequency of cytolytic T lymphocytes directed against a tumor-specific mutated antigen detectable with HLA tetramers in the blood of a lung carcinoma patient with long survival

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24812403

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A point mutation in the alpha-actinin-4 gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human lung carcinoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24812403

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The peptide recognized by HLA-A68.2-restricted, squamous cell carcinoma of the lung-specific cytotoxic T lymphocytes is derived from a mutated elongation factor 2 gene.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24812403

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1251102

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812403 AND SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812403 AND SRC:MED&resulttype=core&format=json

17 March 2020

PubMed publication ID

24812403

1 reference