Alzheimer's disease, estrogens, and clinical trials: a case study in drug development for complex disorders (Q57074482)

Pharmacokinetics and Pharmacodynamics of Conjugated Equine Estrogens: Chemistry and Metabolism

21 January 2018

1 reference

Neuroprotective properties of selective estrogen receptor agonists in cultured neurons.

21 January 2018

1 reference

Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in AD.

21 January 2018

1 reference

The Women's Health Initiative Memory Study: findings and implications for treatment

21 January 2018

1 reference

Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

21 January 2018

1 reference

Economic evaluation of donepezil in moderate to severe Alzheimer disease

21 January 2018

1 reference

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

21 January 2018

1 reference

Evidence of increased oxidative damage in subjects with mild cognitive impairment.

21 January 2018

1 reference

Electron transport chain defects in Alzheimer's disease brain

21 January 2018

1 reference

Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations

21 January 2018

1 reference

Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

Hormone therapy for the prevention of chronic conditions in postmenopausal women: recommendations from the U.S. Preventive Services Task Force

21 January 2018

1 reference

Estrogen use, APOE, and cognitive decline: evidence of gene-environment interaction

21 January 2018

1 reference

Critical in vivo roles for classical estrogen receptors in rapid estrogen actions on intracellular signaling in mouse brain.

21 January 2018

1 reference

7 January 2021

Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase.

1 reference

7 January 2021

Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol

1 reference

7 January 2021

Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial.

1 reference

7 January 2021

Different modes of hippocampal plasticity in response to estrogen in young and aged female rats

1 reference

7 January 2021

Estrogen modulates synaptic N-methyl-D-aspartate receptor subunit distribution in the aged hippocampus

1 reference

7 January 2021

Estrogen stimulates postsynaptic density-95 rapid protein synthesis via the Akt/protein kinase B pathway.

1 reference

7 January 2021

Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice

1 reference

7 January 2021

The 9 year cognitive decline before dementia of the Alzheimer type: a prospective population-based study

1 reference

7 January 2021

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

1 reference

7 January 2021

1 reference

7 January 2021

Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease

1 reference

7 January 2021

The role of Ca2 channel modulation in the neuroprotective actions of estrogen in beta-amyloid protein and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) cytotoxic models

1 reference

7 January 2021

Neuronal microtubules: when the MAP is the roadblock

1 reference

7 January 2021

17beta-estradiol differentially regulates blood-brain barrier permeability in young and aging female rats.

1 reference

7 January 2021

The cholinergic hypothesis of geriatric memory dysfunction

1 reference

7 January 2021

Lessons to be learned from the Vioxx debacle

1 reference

7 January 2021

Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function

1 reference

7 January 2021

Tocopherol (vitamin E) in Alzheimer's disease and other neurodegenerative disorders

1 reference

7 January 2021

Comparison of the antioxidant effects of equine estrogens, red wine components, vitamin E, and probucol on low-density lipoprotein oxidation in postmenopausal women

1 reference

7 January 2021

The tyrosine kinase and mitogen-activated protein kinase pathways mediate multiple effects of estrogen in hippocampus

1 reference

7 January 2021

Estradiol and raloxifene protect cultured SN4741 neurons against oxidative stress.

1 reference

7 January 2021

Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses

1 reference

7 January 2021

Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice

1 reference

7 January 2021

Estrogen receptor ligands. Part 13: Dihydrobenzoxathiin SERAMs with an optimized antagonist side chain

1 reference

7 January 2021

Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain

1 reference

7 January 2021

Reactive astrocytes express estrogen receptors in the injured primate brain

1 reference

7 January 2021

Direct, complex effects of estrogens on basal forebrain cholinergic neurons

1 reference

7 January 2021

17beta-oestradiol up-regulates longevity-related, antioxidant enzyme expression via the ERK1 and ERK2[MAPK]/NFkappaB cascade

1 reference

7 January 2021

Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease

1 reference

7 January 2021

Estradiol activates group I and II metabotropic glutamate receptor signaling, leading to opposing influences on cAMP response element-binding protein.

1 reference

7 January 2021

Proteomic identification of proteins oxidized by Abeta(1-42) in synaptosomes: implications for Alzheimer's disease

1 reference

7 January 2021

Proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid beta-peptide (1-42) into rat brain: implications for Alzheimer's disease

1 reference

7 January 2021

Studies of the metabolism of 17 alpha-estradiol in man

1 reference

7 January 2021

Prevention of age-related dysregulation of calcium dynamics by estrogen in neurons

1 reference

7 January 2021

17beta-Estradiol Induction of Filopodial Growth in Cultured Hippocampal Neurons within Minutes of Exposure

1 reference

7 January 2021

17 beta-Estradiol enhances the outgrowth and survival of neocortical neurons in culture

1 reference

7 January 2021

Mitochondrial abnormalities in Alzheimer brain: mechanistic implications

1 reference

7 January 2021

Prefibrillar amyloid protein aggregates share common features of cytotoxicity.

1 reference

7 January 2021

Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate

1 reference

7 January 2021

Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory

1 reference

7 January 2021

Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome

1 reference

7 January 2021

Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: stereologic analysis of prefrontal cortex area 9.

1 reference

7 January 2021

The metallobiology of Alzheimer's disease

1 reference

7 January 2021

Serum copper: a biomarker for Alzheimer disease?

1 reference

7 January 2021

Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein

1 reference

7 January 2021

Toxicity of amyloid beta peptide: tales of calcium, mitochondria, and oxidative stress

1 reference

7 January 2021

Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus

1 reference

7 January 2021

Cytochrome c oxidase is decreased in Alzheimer's disease platelets

1 reference

7 January 2021

Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities

1 reference

7 January 2021

Mitochondrial localization of ERalpha and ERbeta in human MCF7 cells

1 reference

7 January 2021

Estradiol increases pre- and post-synaptic proteins in the CA1 region of the hippocampus in female rhesus macaques (Macaca mulatta).

1 reference

7 January 2021

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

1 reference

7 January 2021

Strategies for disease modification in Alzheimer's disease

1 reference

7 January 2021

Controversies about HRT--lessons from monkey models

1 reference

7 January 2021

Lack of oestrogen protection in amyloid-mediated endothelial damage due to protein nitrotyrosination

1 reference

7 January 2021

Gonadal hormone modulation of dendrites in the mammalian CNS.

1 reference

7 January 2021

The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection.

1 reference

7 January 2021

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

1 reference

7 January 2021

A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease

1 reference

7 January 2021

1 reference

7 January 2021

Impaired axonal transport of cortical neurons in Alzheimer's disease is associated with neuropathological changes

1 reference

7 January 2021

Acetylcholine mediates the estrogen-induced increase in NMDA receptor binding in CA1 of the hippocampus and the associated improvement in working memory.

1 reference

7 January 2021

Estradiol replacement enhances working memory in middle-aged rats when initiated immediately after ovariectomy but not after a long-term period of ovarian hormone deprivation

1 reference

7 January 2021

Differential effects of estrogen on hippocampal- and striatal-dependent learning

1 reference

7 January 2021

Pathology and pathways of Alzheimer's disease with an update on new developments in treatment.

1 reference

7 January 2021

Alzheimer pathology disorganizes cortico-cortical circuitry: direct evidence from a transgenic animal model.

1 reference

7 January 2021

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

1 reference

7 January 2021

Higher estrogen levels are not associated with larger hippocampi and better memory performance

1 reference

7 January 2021

Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: involvement of nonclassical genomic signaling pathways

1 reference

7 January 2021

Neuropathology of Alzheimer's disease and other dementias

1 reference

7 January 2021

Beta-amyloid regulation of presynaptic nicotinic receptors in rat hippocampus and neocortex.

1 reference

7 January 2021

Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog

1 reference

7 January 2021

Development of 17alpha-estradiol as a neuroprotective therapeutic agent: rationale and results from a phase I clinical study

1 reference

7 January 2021

Estrogen- and tamoxifen-associated effects on brain structure and function

1 reference

7 January 2021

Selective sparing of brain tissue in postmenopausal women receiving hormone replacement therapy

1 reference

7 January 2021

Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study

1 reference

7 January 2021

Living with the enemy: a physiological role for the beta-amyloid peptide

1 reference

7 January 2021

Color-coded diffusion-tensor-imaging of posterior cingulate fiber tracts in mild cognitive impairment

1 reference

7 January 2021

Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairment

1 reference

7 January 2021

Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones.

1 reference

7 January 2021

17beta-estradiol: effect on CA1 hippocampal synaptic plasticity

1 reference

7 January 2021

17beta-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation

1 reference

7 January 2021

Behavioral training interferes with the ability of gonadal hormones to increase CA1 spine synapse density in ovariectomized female rats

1 reference

7 January 2021

The cholinergic pathology in Alzheimer's disease--discrepancies between clinical experience and pathophysiological findings

1 reference

7 January 2021

Estrogen enhances potassium-stimulated acetylcholine release in the rat hippocampus

1 reference

7 January 2021

Expanded coverage of the human heart mitochondrial proteome using multidimensional liquid chromatography coupled with tandem mass spectrometry.

1 reference

7 January 2021

Dendritic spine plasticity in hippocampus.

1 reference

7 January 2021

Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study

1 reference

7 January 2021

Inhibition of energy metabolism down-regulates the Alzheimer related presenilin 2 gene.

1 reference

7 January 2021

17beta-estradiol inhibits inflammatory gene expression by controlling NF-kappaB intracellular localization

1 reference

7 January 2021

Estrogen and cognition: applying preclinical findings to clinical perspectives

1 reference

7 January 2021

Glycogen synthase kinase 3beta links neuroprotection by 17beta-estradiol to key Alzheimer processes

1 reference

7 January 2021

Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II)

1 reference

7 January 2021

Estrogen therapy fails to alter amyloid deposition in the PDAPP model of Alzheimer's disease

1 reference

7 January 2021

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

1 reference

7 January 2021

Estrogen increases the number of spinophilin-immunoreactive spines in the hippocampus of young and aged female rhesus monkeys

1 reference

7 January 2021

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

7 January 2021

Is the WHI relevant to HRT started in the perimenopause?

1 reference

7 January 2021

Role of Protein Aggregation in Mitochondrial Dysfunction and Neurodegeneration in Alzheimer's and Parkinson's Diseases

1 reference

7 January 2021

Estrogen treatment improves spatial learning in APP PS1 mice but does not affect beta amyloid accumulation and plaque formation

1 reference

7 January 2021

Postmenopausal hormone therapy and Alzheimer's disease risk: interaction with age

1 reference

7 January 2021

Dissecting physiological roles of estrogen receptor alpha and beta with potent selective ligands from structure-based design

1 reference

7 January 2021

Mitochondrial abnormalities in Alzheimer's disease.

1 reference

7 January 2021

Some new aspects of 17alpha-estradiol metabolism in man.

1 reference

7 January 2021

The nature of the effect of female gonadal hormone replacement therapy on cognitive function in post-menopausal women: a meta-analysis.

1 reference

7 January 2021

Pathology of presynaptic proteins in Alzheimer's disease: more than simple loss of terminals.

1 reference

7 January 2021

Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease.

1 reference

7 January 2021

Noncardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II).

1 reference

7 January 2021

Neurovascular regulation in the normal brain and in Alzheimer's disease

1 reference

7 January 2021

Long-term cholinesterase inhibitor treatment of Alzheimer's disease.

1 reference

7 January 2021

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

1 reference

7 January 2021

APP processing and synaptic function

1 reference

7 January 2021

Postmenopausal hormone therapy and risk of cognitive decline in community-dwelling aging women

1 reference

7 January 2021

Estrogen modulation of G-protein-coupled receptor activation of potassium channels in the central nervous system

1 reference

7 January 2021

Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease

1 reference

7 January 2021

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo

1 reference

7 January 2021

The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog?

1 reference

7 January 2021

Role of estrogen in balancing contributions from multiple memory systems

1 reference

7 January 2021

Hippocampal synapses depend on hippocampal estrogen synthesis.

1 reference

7 January 2021

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

1 reference

7 January 2021

Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer's disease

1 reference

7 January 2021

Structural plasticity and memory

1 reference

7 January 2021

Back to the future: the 'old-fashioned' way to new medications for neurodegeneration

1 reference

7 January 2021

Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited

1 reference

7 January 2021

Hormone replacement therapy and cognition: systematic review and meta-analysis

1 reference

7 January 2021

Perspectives on the amyloid-beta cascade hypothesis

1 reference

7 January 2021

Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications

1 reference

7 January 2021

Estrogen induces phosphorylation of cyclic AMP response element binding (pCREB) in primary hippocampal cells in a time-dependent manner

1 reference

7 January 2021

Current opinions and understandings of menopausal women about hormone replacement therapy (HRT)-the University of Florida experience

1 reference

7 January 2021

Integration of the extranuclear and nuclear actions of estrogen

1 reference

7 January 2021

Brain region-specific up-regulation of mouse apolipoprotein E by pharmacological estrogen treatments

1 reference

7 January 2021

17Alpha-estradiol and 17beta-estradiol treatments are effective in lowering cerebral amyloid-beta levels in AbetaPPSWE transgenic mice

1 reference

7 January 2021

The Amyloid Hypothesis and the clearance and degradation of Alzheimer's beta-peptide.

1 reference

7 January 2021

Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial memory in female mice

1 reference

7 January 2021

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

1 reference

7 January 2021

Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection

1 reference

7 January 2021

Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity

1 reference

7 January 2021

Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations

1 reference

7 January 2021

Alteration of a clinically meaningful outcome in the natural history of Alzheimer's disease by cholinesterase inhibition.

1 reference

7 January 2021

Quantitative proteomic analysis of mitochondria from primary neuron cultures treated with amyloid beta peptide

1 reference

7 January 2021

Rapid enhancement of visual and place memory by estrogens in rats.

1 reference

7 January 2021

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

1 reference

7 January 2021

Estrogen and Alzheimer's disease: the apolipoprotein connection.

1 reference

7 January 2021

The 17alpha and 17beta isomers of estradiol both induce rapid spine synapse formation in the CA1 hippocampal subfield of ovariectomized female rats.

1 reference

7 January 2021

Hormone in the hot seat

1 reference

7 January 2021

Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.

1 reference

7 January 2021

Pathways towards and away from Alzheimer's disease

1 reference

7 January 2021

Epidemiology of neurodegeneration

1 reference

7 January 2021

Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones

1 reference

7 January 2021

Estrogen actions throughout the brain

1 reference

7 January 2021

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

1 reference

7 January 2021

Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor alpha and is involved in the regulation of receptor activity

1 reference

7 January 2021

Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles

1 reference

7 January 2021

The cholinergic lesion of Alzheimer's disease: pivotal factor or side show?

1 reference

7 January 2021

Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients

1 reference

7 January 2021

Labeled cortical mantle distance maps of the cingulate quantify differences between dementia of the Alzheimer type and healthy aging.

1 reference

7 January 2021

Breast cancer and hormone-replacement therapy in the Million Women Study

1 reference

7 January 2021

Ultrastructural localization of estrogen receptor beta immunoreactivity in the rat hippocampal formation

1 reference

7 January 2021

Role of hydrogen peroxide in the aetiology of Alzheimer's disease: implications for treatment.

1 reference

7 January 2021

New evidence regarding hormone replacement therapies is urgently required transdermal postmenopausal hormone therapy differs from oral hormone therapy in risks and benefits

1 reference

7 January 2021

The glomerular slit diaphragm is a modified adherens junction

1 reference

7 January 2021

Dendrite and dendritic spine alterations in Alzheimer models

1 reference

7 January 2021

A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons

1 reference

7 January 2021

Life and Death of Neurons in the Aging Brain

1 reference

7 January 2021

Gonadal steroids influence axon sprouting in the hippocampal dentate gyrus: a sexually dimorphic response

1 reference

7 January 2021

Promotion of oxidative lipid membrane damage by amyloid beta proteins

1 reference

7 January 2021

The Women's Health Initiative could not have detected cardioprotective effects of starting hormone therapy during the menopausal transition

1 reference

7 January 2021

Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease.

1 reference

7 January 2021

Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease

1 reference

7 January 2021

Estrogen facilitates neurite extension via apolipoprotein E in cultured adult mouse cortical neurons

1 reference

7 January 2021

Advances in the early detection of Alzheimer's disease

1 reference

7 January 2021

Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate

1 reference

7 January 2021

Mechanism of estrogen-mediated neuroprotection: regulation of mitochondrial calcium and Bcl-2 expression

1 reference

7 January 2021

Mitochondria as therapeutic targets of estrogen action in the central nervous system

1 reference

7 January 2021

Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease

1 reference

7 January 2021

Cytochrome oxidase deficiency in Alzheimer's disease

1 reference

7 January 2021

Medroxyprogesterone acetate antagonizes the effects of estrogen treatment on social and sexual behavior in female macaques

1 reference

7 January 2021

How heritable is Alzheimer's disease late in life? Findings from Swedish twins.

1 reference

7 January 2021

Expression of estrogen receptor alpha exon-deleted mRNA variants in the human and non-human primate frontal cortex

1 reference

7 January 2021

beta-amyloid is different in normal aging and in Alzheimer disease.

1 reference

7 January 2021

Abnormal Ca2 -calmodulin-dependent protein kinase II function mediates synaptic and motor deficits in experimental parkinsonism.

1 reference

7 January 2021

Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport

1 reference

7 January 2021

The production of amyloid beta peptide is a critical requirement for the viability of central neurons.

1 reference

7 January 2021

Median raphe mediates estrogenic effects to the hippocampus in female rats

1 reference

7 January 2021

Science, pharmacoeconomics and ethics in drug R&D: a sustainable future scenario?

1 reference

7 January 2021

Amyloid-beta peptide inhibits activation of the nitric oxide/cGMP/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity.

1 reference

7 January 2021

Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons

1 reference

7 January 2021

Suppression of longitudinal increase in CSF F2-isoprostanes in Alzheimer's disease.

1 reference

7 January 2021

Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys.

1 reference

7 January 2021

Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial

1 reference

7 January 2021

Estrogen use and brain metabolic change in postmenopausal women

1 reference

7 January 2021

A transmembrane intracellular estrogen receptor mediates rapid cell signaling

1 reference

7 January 2021

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

1 reference

7 January 2021

High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease

1 reference

7 January 2021

Estradiol (E2) enhances neurite outgrowth by repressing glial fibrillary acidic protein expression and reorganizing laminin

1 reference

7 January 2021

Selective estrogen receptor modulators regulate phasic activation of hippocampal CA1 pyramidal cells by estrogen

1 reference

7 January 2021

A role for the basal forebrain cholinergic system in estrogen-induced disinhibition of hippocampal pyramidal cells.

1 reference

7 January 2021

Presynaptic N-methyl-D-aspartate receptor expression is increased by estrogen in an aromatase-rich area of the songbird hippocampus

1 reference

7 January 2021

Src kinases: a hub for NMDA receptor regulation

1 reference

7 January 2021

Tau suppression in a neurodegenerative mouse model improves memory function

1 reference

7 January 2021

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

1 reference

7 January 2021

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

1 reference

7 January 2021

Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk

1 reference

7 January 2021

1 reference

7 January 2021

Current progress in beta-amyloid immunotherapy

1 reference

7 January 2021

Short-term transdermal estradiol therapy, cognition and depressive symptoms in healthy older women. A randomised placebo controlled pilot cross-over study

1 reference

7 January 2021

AD2000: donepezil in Alzheimer's disease

1 reference

7 January 2021

Estradiol induces formation of dendritic spines in hippocampal neurons: functional correlates

1 reference

7 January 2021

Alzheimer's disease is a synaptic failure

1 reference

7 January 2021

Genes involved in Alzheimer's disease, a survey of possible candidates

1 reference

7 January 2021

17 β-Estradiol alleviates synergistic oxidative stress resulting from folate deprivation and amyloid-β treatment

1 reference

7 January 2021

Estrogen and memory in women: how can we reconcile the findings?

1 reference

7 January 2021

The Women’s Health Initiative Memory Study (WHIMS)

1 reference

7 January 2021

Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial

1 reference

7 January 2021

Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study

1 reference

7 January 2021

In vitro bioactivity of 17alpha-estradiol

1 reference

7 January 2021

Mitochondria play a central role in estrogen-induced neuroprotection.

1 reference

7 January 2021

Climacteric medicine: European Menopause and Andropause Society (EMAS) 2004/2005 position statements on peri- and postmenopausal hormone replacement therapy

1 reference

7 January 2021

Do acetylcholinesterase inhibitors boost synaptic scaling in Alzheimer's disease?

1 reference

7 January 2021

Alzheimer's disease and Abeta toxicity: from top to bottom

1 reference

7 January 2021

Estrogen-induced increase in the magnitude of long-term potentiation occurs only when the ratio of NMDA transmission to AMPA transmission is increased.

1 reference

7 January 2021

Regulation of NMDA receptor trafficking by amyloid-beta

1 reference

7 January 2021

Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death.

1 reference

7 January 2021

Practical guidelines for postmenopausal hormone therapy.

1 reference

7 January 2021

Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy

1 reference

7 January 2021

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

1 reference

7 January 2021

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

1 reference

7 January 2021

“Up to general practice to pick up the pieces”—what pieces?—a response to WHI and MWS

1 reference

7 January 2021

Second thoughts on the women's health initiative study: the effect of age on the safety of HRT

1 reference

7 January 2021

Abnormality of G-protein-coupled receptor kinases at prodromal and early stages of Alzheimer's disease: an association with early beta-amyloid accumulation.

1 reference

7 January 2021

Mitogen-activated protein kinases in synaptic plasticity and memory.

1 reference

7 January 2021

Estrogen increases brain expression of the mRNA encoding transthyretin, an amyloid beta scavenger protein.

1 reference

7 January 2021

Estrogen levels do not correlate with improvement in cognition

1 reference

7 January 2021

Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial

1 reference

7 January 2021

Effects of two years of estrogen loss or replacement on nucleus basalis cholinergic neurons and cholinergic fibers to the dorsolateral prefrontal and inferior parietal cortex of monkeys

1 reference

7 January 2021

Minireview: A plethora of estrogen receptors in the brain: where will it end?

1 reference

7 January 2021

Estrogen and the brain: beyond ER-alpha and ER-beta

1 reference

7 January 2021

17alpha-estradiol: a brain-active estrogen?

1 reference

7 January 2021

Subcellular relationships between cholinergic terminals and estrogen receptor-alpha in the dorsal hippocampus

1 reference

7 January 2021

Mitochondrial abnormalities in cybrid cell models of sporadic Alzheimer's disease worsen with passage in culture

1 reference

7 January 2021

Hormone therapy: physiological complexity belies therapeutic simplicity

1 reference

7 January 2021

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

1 reference

7 January 2021

Early changes in Abeta levels in the brain of APPswe transgenic mice--implication on synaptic density, alpha7 neuronal nicotinic acetylcholine- and N-methyl-D-aspartate receptor levels.

1 reference

7 January 2021

Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration.

1 reference

7 January 2021

What are the treatment options for patients with severe Alzheimer's disease?

1 reference

7 January 2021

Differential effects of oral versus transdermal estrogen replacement therapy on C-reactive protein in postmenopausal women

1 reference

7 January 2021

17beta-estradiol suppresses expression of long-term depression in aged rats

1 reference

7 January 2021

Deciphering the molecular basis of memory failure in Alzheimer's disease

1 reference

7 January 2021

Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components

1 reference

7 January 2021

Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation

1 reference

7 January 2021

Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3-nitroproprionic acid in SK-N-SH human neuroblastoma cells

1 reference

7 January 2021

Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease

1 reference

7 January 2021

Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide.

1 reference

7 January 2021

Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative: a randomized trial

1 reference

7 January 2021

Hippocampal neurons in pre-clinical Alzheimer's disease.

1 reference

7 January 2021

Metabolism of 17-alpha-estradiol-6,7-3H by nonpregnant women

1 reference

7 January 2021

Cost effectiveness of cholinesterase inhibitors in the treatment of Alzheimer's disease: a review with methodological considerations

1 reference

7 January 2021

Long-term treatment of Alzheimer disease: efficacy and safety of acetylcholinesterase inhibitors

1 reference

7 January 2021

Minireview: neuroprotective effects of estrogen-new insights into mechanisms of action

1 reference

7 January 2021

Cytochrome oxidase in Alzheimer's disease: Biochemical, histochemical, and immunohistochemical analyses of the visual and other systems

1 reference

7 January 2021

Estrogen-mediated structural and functional synaptic plasticity in the female rat hippocampus

1 reference

7 January 2021

Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons

1 reference

7 January 2021

Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial

1 reference

7 January 2021

Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analyses

1 reference

7 January 2021

beta-Amyloid directly inhibits human alpha4beta2-nicotinic acetylcholine receptors heterologously expressed in human SH-EP1 cells

1 reference

7 January 2021

Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease

1 reference

7 January 2021

17Beta-estradiol induced Ca2 influx via L-type calcium channels activates the Src/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: a potential initiation mechanism for estrogen-induced

1 reference

7 January 2021

The estrogen receptor is not essential for all estrogen neuroprotection: new evidence from a new analog

1 reference

7 January 2021

Estrogen therapy in postmenopausal women: effects on cognitive function and dementia

1 reference

7 January 2021

Effect of raloxifene on prevention of dementia and cognitive impairment in older women: the Multiple Outcomes of Raloxifene Evaluation (MORE) randomized trial

1 reference

7 January 2021

Mitochondrial localization of estrogen receptor beta

1 reference

7 January 2021

Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation

1 reference

7 January 2021

Role of protein phosphatases in estrogen-mediated neuroprotection.

1 reference

7 January 2021

Estrogen enhances depolarization-induced glutamate release through activation of phosphatidylinositol 3-kinase and mitogen-activated protein kinase in cultured hippocampal neurons

1 reference

7 January 2021

Involvement of insulin/phosphoinositide 3-kinase/Akt signal pathway in 17 beta-estradiol-mediated neuroprotection

1 reference

7 January 2021

Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model

1 reference

7 January 2021

Microtubule regulation of N-methyl-D-aspartate receptor channels in neurons

1 reference

7 January 2021

Estradiol modulates long-term synaptic depression in female rat hippocampus

1 reference

7 January 2021

Estradiol increases delayed, N-methyl-D-aspartate receptor-mediated excitation in the hippocampal CA1 region

1 reference

7 January 2021

Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study

1 reference

7 January 2021

The effects of estrogen replacement therapy on neuropsychological functioning in postmenopausal women with and without dementia: a critical and theoretical review

1 reference

7 January 2021

Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons

1 reference

7 January 2021

17beta-estradiol induces Ca2 influx, dendritic and nuclear Ca2 rise and subsequent cyclic AMP response element-binding protein activation in hippocampal neurons: a potential initiation mechanism for estrogen neurotrophism

1 reference

7 January 2021

Alzheimer's disease: the two-hit hypothesis

1 reference

7 January 2021

Neuroprotective properties of Bcl-w in Alzheimer disease

1 reference

7 January 2021

Neurovascular mechanisms of Alzheimer's neurodegeneration

1 reference

7 January 2021

Estrogen levels regulate the subcellular distribution of phosphorylated Akt in hippocampal CA1 dendrites.

1 reference

7 January 2021