Proteome Analysis Reveals the Conidial Surface Protein CcpA Essential for Virulence of the Pathogenic Fungus (Q57048245)

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26 April 2020

title

Proteome Analysis Reveals the Conidial Surface Protein CcpA Essential for Virulence of the Pathogenic Fungus Aspergillus fumigatus (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30279286 AND SRC:MED&resulttype=core&format=json

Conidial cell wall protein A

26 April 2020

main subject

1 reference

GeneDB

short chain dehydrogenase atsC, putative

5 February 2019

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putative oxidoreductase, 2OG-Fe(II) oxygenase family protein

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protein of unknown function

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Ortholog of Aspergillus fumigatus A1163 : AFUB_003990

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Ortholog(s) have cell adhesion molecule binding, glucan endo-1,6-beta-glucosidase activity, glucan exo-1,3-beta-glucosidase activity

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FG-GAP repeat protein

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Ortholog(s) have ARF guanyl-nucleotide exchange factor activity, role in SRP-dependent cotranslational protein targeting to membrane and Ssh1 translocon complex localization

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Has domain(s) with predicted phosphoric diester hydrolase activity and role in lipid metabolic process

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40S ribosomal protein S3

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Secreted beta-glucosidase

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Ortholog(s) have glutathione disulfide oxidoreductase activity, glutathione peroxidase activity, glutathione transferase activity

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Putative translation elongation factor EF-1 alpha subunit

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Molecular chaperone

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Protein with Yap1-dependent induction in response to hydrogen peroxide

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putative phosphoglycerate kinase

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Putative eukaryotic translation elongation factor 1 subunit eEF1-beta

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Ortholog(s) have copper ion binding, superoxide dismutase activity and role in cellular response to superoxide, evasion or tolerance by symbiont of host-produced reactive oxygen species, pathogenesis, superoxide metabolic process

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Ortholog(s) have glycine dehydrogenase (decarboxylating) activity, role in glycine catabolic process, one-carbon metabolic process, protein lipoylation and mitochondrion localization

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Protein of unknown function identified by mass spectrometry

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Has domain(s) with predicted DNA binding, protein heterodimerization activity, role in DNA-templated transcription, initiation, nucleosome assembly and nucleosome, nucleus localization

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Histone H3

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exo-beta-1,3-glucanase

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Putative manganese superoxide dismutase

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Putative alpha-glucosidase B

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Putative heat shock protein

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1,3-beta-glucanosyltransferase with a role in elongation of 1,3-beta-glucan chains

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Ortholog of Neosartorya fischeri NRRL 181 : NFIA_034050, NFIA_063470, Aspergillus wentii : Aspwe1_0038124, Aspwe1_0546044 and Aspergillus versicolor : Aspve1_0029373

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14-3-3 family protein

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Putative pheromone processing carboxypeptidase

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Ortholog of Aspergillus fumigatus A1163 : AFUB_022080

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Ortholog(s) have extracellular region localization

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Ortholog of Neosartorya fischeri NRRL 181 : NFIA_082360 and Aspergillus fumigatus A1163 : AFUB_022660

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Ribosomal protein L18

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Has domain(s) with predicted heme binding activity

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Putative mitochondrial Hsp70 chaperone

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Immunoreactive protein

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Allergen Asp f 8

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Putative acylCoA binding family protein

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Ortholog(s) have role in cellular metal ion homeostasis, cellular response to biotic stimulus and cellular response to starvation, more

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Ortholog(s) have role in intracellular sterol transport and fungal-type vacuole lumen localization

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Putative ATP synthase oligomycin sensitivity conferral protein

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Allergen Asp f 13

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Putative translation elongation factor EF-2 subunit

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Transcript up-regulated in conidia exposed to neutrophils

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Ortholog of Aspergillus fumigatus A1163 : AFUB_029950

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Conidia-enriched protein of unknown function

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Cell wall glucanase

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Mycelial catalase

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Aspergillopepsin II

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Ortholog of A. oryzae RIB40 : AO090010000310, Aspergillus wentii : Aspwe1_0294100, Aspwe1_0531408, Aspergillus niger ATCC 1015 : 53802-mRNA and Aspergillus terreus NIH2624 : ATET_10090

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Histone H2B

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Ortholog(s) have ribosomal small subunit binding, translation initiation factor activity, translation initiation factor binding activity and role in formation of translation preinitiation complex, maintenance of translational fidelity

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Putative glutaminase A

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Putative peptidyl-prolyl cis-trans isomerase

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Putative inorganic diphosphatase

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Putative protease

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Ortholog of Neosartorya fischeri NRRL 181 : NFIA_067470 and Aspergillus fumigatus A1163 : AFUB_039340

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Ubiquitin

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Aspartic acid endopeptidase

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Ortholog of A. nidulans FGSC A4 : AN2894, A. niger CBS 513.88 : An02g07350, A. oryzae RIB40 : AO095003000710, Aspergillus wentii : Aspwe1_0025131 and Aspergillus sydowii : Aspsy1_0775782

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Non-histone chromosomal protein

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Putative glutathione peroxidase

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Has domain(s) with predicted NADH dehydrogenase (ubiquinone) activity and mitochondrion localization

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Ortholog of A. niger CBS 513.88 : An09g04240, A. oryzae RIB40 : AO090012000670, Neosartorya fischeri NRRL 181 : NFIA_063040 and Aspergillus wentii : Aspwe1_0038047

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Dehydrin-like protein

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Asp hemolysin-like protein

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Putative cell wall galactomannoprotein

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Putative secreted protease

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Putative outer mitochondrial membrane protein porin

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Putative glycophosphatidylinositol (GPI)-anchored cell wall protein

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BYS1 domain protein

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Putative extracellular lipase

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cytochrome c oxidase subunit Va with a predicted role in oxidative phosphorylation

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Ortholog(s) have flavin-linked sulfhydryl oxidase activity, role in oxidation-reduction process and extracellular region localization

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Heat shock protein

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Putative single-stranded DNA binding protein family member

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Autophagic (vacuolar) serine protease

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Cu/Zn superoxide dismutase

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Conidial hydrophobin

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ATP synthase F1, beta subunit

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Cofilin

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Allergen Asp f 29

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Ortholog of A. nidulans FGSC A4 : AN6856, A. niger CBS 513.88 : An14g06050, A. oryzae RIB40 : AO090120000435, Aspergillus wentii : Aspwe1_0107169 and Aspergillus sydowii : Aspsy1_0040420

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Putative Hsp90 binding co-chaperone

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Glucose-repressible gene

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Allergen Asp f 3

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protein of unknown function

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Nascent polypeptide-associated complex subunit alpha

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actin

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Putative NAD-dependent malate dehydrogenase with a predicted role in the citric acid cycle

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Ortholog(s) have RNA binding activity and role in mRNA splicing, via spliceosome, maturation of SSU-rRNA

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Putative enolase

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Ortholog of A. nidulans FGSC A4 : AN1941, A. niger CBS 513.88 : An11g02730, Neosartorya fischeri NRRL 181 : NFIA_053540 and Aspergillus versicolor : Aspve1_0025340

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Allergen Asp f 28

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Ortholog(s) have chaperone binding, unfolded protein binding activity, role in chaperone-mediated protein complex assembly, protein import into mitochondrial intermembrane space, protein refolding and mitochondrial matrix localization

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protein of unknown function

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flavoprotein amide oxidase (FAD)

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Putative FK506-binding protein (FKBP)-type peptidyl-prolyl cis-trans isomerase

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Putative heat shock protein

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Ortholog(s) have hydrolase activity, role in nucleotide metabolic process and cytosol, nucleus localization

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Ortholog of A. nidulans FGSC A4 : AN5353, A. niger CBS 513.88 : An02g05680, A. oryzae RIB40 : AO090103000108, Aspergillus wentii : Aspwe1_0131073 and Aspergillus sydowii : Aspsy1_0050268

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Ortholog of A. nidulans FGSC A4 : AN7941, A. fumigatus Af293 : Afu2g12680, A. niger CBS 513.88 : An03g01770, Aspergillus sydowii : Aspsy1_0156290 and Aspergillus terreus NIH2624 : ATET_07370

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Has domain(s) with predicted hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances activity, role in proton transport and vacuolar proton-transporting V-type ATPase complex localization

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Ortholog of A. nidulans FGSC A4 : AN4256, A. oryzae RIB40 : AO090012000139, Neosartorya fischeri NRRL 181 : NFIA_099750 and Aspergillus versicolor : Aspve1_0055292

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Putative tropomyosin 1

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Putative NAD-dependent malate dehydrogenase

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Putative secreted 1,4-beta-D-glucan glucanhydrolase

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Has domain(s) with predicted role in cell adhesion

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Ortholog(s) have extracellular region localization

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Putative secreted N-acetylhexosaminidase

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Putative mitochondrial F1 ATPase subunit alpha

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Putative glycosylphosphatidylinositol (GPI)-linked protein

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Has domain(s) with predicted role in protein folding and cytoplasm localization

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Ortholog of A. nidulans FGSC A4 : AN1603, Neosartorya fischeri NRRL 181 : NFIA_098760, NFIA_099140, Aspergillus wentii : Aspwe1_0689083 and Aspergillus versicolor : Aspve1_0037404

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2

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26 April 2020

Alexander Scheffold

14

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26 April 2020

Juergen Loeffler

15

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Olaf Kniemeyer

20

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Axel A Brakhage

23

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21

Scott G Filler

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Thorsten Heinekamp

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author name string

Vera Voltersen

1

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Sahra Herrmann

3

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Franziska Schmidt

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Maria Strassburger

6

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Thomas Krüger

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Petra Bacher

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Jasmin Lother

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Esther Weiss

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Kerstin Hünniger

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Hong Liu

12

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Peter Hortschansky

13

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Sven Krappmann

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Sandor Nietzsche

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Oliver Kurzai

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Utz Reichard

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Hermann Einsele

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language of work or name

English

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publication date

2 October 2018

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volume

9

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issue

5

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

26 April 2020

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Conidial Dihydroxynaphthalene Melanin of the Human Pathogenic Fungus Aspergillus fumigatus Interferes with the Host Endocytosis Pathway

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Development stage-specific proteomic profiling uncovers small, lineage specific proteins most abundant in the Aspergillus Fumigatus conidial proteome

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Identifiers

DOI

10.1128/MBIO.01557-18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30279286 AND SRC:MED&resulttype=core&format=json

26 April 2020

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26 April 2020

PubMed publication ID

30279286

1 reference