S. mansoni Schistosomula Antigens Induce Th1/Proinflammatory Cytokine Responses (Q56909282)

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object named as

Cornelis H Hokke

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Edridah M Tukahebwa

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object named as

Edridah M Tukahebwa

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author name string

Moses Egesa

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Lawrence Lubyayi

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Bernard S Bagaya

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Iain W Chalmers

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Shona Wilson

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Karl F Hoffmann

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David W Dunne

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Lucja A Labuda

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Stephen Cose

The generation of interferon-gamma-producing T lymphocytes in skin-draining lymph nodes, and their recruitment to the lungs, is associated with protective immunity to Schistosoma mansoni

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language of work or name

English

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publication date

21 September 2018

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published in

Parasite Immunology

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page(s)

e12592

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cites work

1 reference

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A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni

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CD4 T cells of schistosomiasis naturally resistant individuals living in an endemic area produce interferon-gamma and tumour necrosis factor-alpha in response to the recombinant 14KDA Schistosoma mansoni fatty acid-binding protein.

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Antibodies to glycans dominate the host response to schistosome larvae and eggs: is their role protective or subversive?

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Interleukin-12 p40 secretion by cutaneous CD11c and F4/80 cells is a major feature of the innate immune response in mice that develop Th1-mediated protective immunity to Schistosoma mansoni

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The relationship between age, sex, egg-count and specific antibody responses against Schistosoma mansoni antigens in a Ugandan fishing community

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Cytokine production in whole blood cultures from a fishing community in an area of high endemicity for Schistosoma mansoni in Uganda: the differential effect of parasite worm and egg antigens

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Ion channels and lymphocyte activation

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Identification of novel proteases and immunomodulators in the secretions of schistosome cercariae that facilitate host entry.

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Human antibody responses of patients living in endemic areas for schistosomiasis to the tegumental protein Sm29 identified through genomic studies.

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Increased human IgE induced by killing Schistosoma mansoni in vivo is associated with pretreatment Th2 cytokine responsiveness to worm antigens

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Schistosoma mansoni tegument protein Sm29 is able to induce a Th1-type of immune response and protection against parasite infection

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Schistosoma mansoni ex vivo lung-stage larvae excretory-secretory antigens as vaccine candidates against schistosomiasis

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Immune effector mechanisms against schistosomiasis: looking for a chink in the parasite's armour

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Fluorescent imaging of antigen released by a skin-invading helminth reveals differential uptake and activation profiles by antigen presenting cells

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Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses

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Transcriptional changes in Schistosoma mansoni during early schistosomula development and in the presence of erythrocytes

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Influence of exposure history on the immunology and development of resistance to human Schistosomiasis mansoni

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Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnover

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Screening the Schistosoma mansoni transcriptome for genes differentially expressed in the schistosomulum stage in search for vaccine candidates.

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Developing vaccines to combat hookworm infection and intestinal schistosomiasis

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Immunization with newly transformed Schistosoma mansoni schistosomula tegument elicits tegument damage, reduction in egg and parasite burden

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In vitro praziquantel test capable of detecting reduced in vivo efficacy in Schistosoma mansoni human infections

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Enzymatic shaving of the tegument surface of live schistosomes for proteomic analysis: a rational approach to select vaccine candidates

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Gene expression patterns in larval Schistosoma mansoni associated with infection of the mammalian host

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Murine CD8 T cell cytotoxicity against schistosomula induced by inoculation of schistosomal 22.6/26GST coupled Sepharose 4B beads

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Short-chain peptides identification of scorpion Buthus martensi Karsch venom by employing high orthogonal 2D-HPLC system and tandem mass spectrometry

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T-helper 17 cells are associated with pathology in human schistosomiasis

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Schistosome infection is associated with enhanced whole-blood IL-10 secretion in response to cercarial excretory/secretory products

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On the three-finger protein domain fold and CD59-like proteins in Schistosoma mansoni.

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Schistosomiasis elimination strategies and potential role of a vaccine in achieving global health goals

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A multivalent chimeric vaccine composed of Schistosoma mansoni SmTSP-2 and Sm29 was able to induce protection against infection in mice.

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12 December 2020

Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression.

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Discovery of novel Schistosoma japonicum antigens using a targeted protein microarray approach.

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Can mass drug administration lead to the sustainable control of schistosomiasis?

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Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection

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Drug-induced exposure of Schistosoma mansoni antigens SmCD59a and SmKK7

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Eliminating Schistosomes through Vaccination: What are the Best Immune Weapons?

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Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment

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Schistosomiasis vaccine candidate Sm14/GLA-SE: Phase 1 safety and immunogenicity clinical trial in healthy, male adults.

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Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission

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Reduced Efficacy of Praziquantel Against Schistosoma mansoni Is Associated With Multiple Rounds of Mass Drug Administration

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Schistosomiasis and soil-transmitted helminthiases: number of people treated in 2016

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Schistosoma mansoni schistosomula antigens induce Th1/Pro-inflammatory cytokine responses

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12 December 2020