IL-27 inhibits the development of regulatory T cells via STAT3 (Q56900809)

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Vera Steinwald

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Anna Guralnik

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Anne Brüstle

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Peter Kleemann

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Christine Rosenplänter

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Thomas Decker

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Michael Lohoff

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4 T cells

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language of work or name

English

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publication date

February 2008

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published in

International Immunology

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volume

20

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issue

2

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page(s)

223-34

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cites work

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Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway

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Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-gamma-mediated pathways

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WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

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Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27.

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Positive and negative regulation of the IL-27 receptor during lymphoid cell activation

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IL-27 and IFN-αSignal via Stat1 and Stat3 and Induce T-Bet and IL-12Rβ2 in Naive T Cells

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IL-27 regulates IL-12 responsiveness of naive CD4 T cells through Stat1-dependent and -independent mechanisms

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An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4 T cells

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Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment

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Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

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IL-27 limits IL-2 production during Th1 differentiation.

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IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3.

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Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4 T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4 T cells partially through STAT3-dependent mechanism.

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The lifestyle of naturally occurring CD4 CD25 Foxp3 regulatory T cells

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Naturally arising CD4 regulatory t cells for immunologic self-tolerance and negative control of immune responses

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Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms

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Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor

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Control of regulatory T cell development by the transcription factor Foxp3

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An essential role for Scurfin in CD4 CD25 T regulatory cells

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X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

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STAT3 regulates cytokine-mediated generation of inflammatory helper T cells

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Nonredundant roles for Stat5a/b in directly regulating Foxp3

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IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

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IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

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Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation

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Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4.

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Interleukin-1beta attenuates renin gene expression via a mitogen-activated protein kinase kinase-extracellular signal-regulated kinase and signal transducer and activator of transcription 3-dependent mechanism in As4.1 cells

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Stat3 activation is required for cell proliferation and tumorigenesis but not for cell viability in cutaneous squamous cell carcinoma cell lines

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Foxp3 programs the development and function of CD4 CD25 regulatory T cells

21 January 2018

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Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis

21 January 2018

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T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis

21 January 2018

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Foxp3-dependent programme of regulatory T-cell differentiation

21 January 2018

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