HighNPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML (Q56607660)

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title

High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML (English)

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9

Timothy A Graubert

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David P Steensma

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Martha Wadleigh

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Richard M Stone

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author name string

Valentina Nardi

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Sanjay S Patel

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Frank C Kuo

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Christopher J Gibson

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Robert J Soiffer

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Edwin P Alyea

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Yi-Bin A Chen

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Amir T Fathi

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Andrew M Brunner

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Daniel J DeAngelo

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Robert P Hasserjian

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Olga K Weinberg

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language of work or name

English

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publication date

3 May 2018

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volume

131

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issue

25

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page(s)

2816-2825

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Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia

25 March 2020

cites work

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12 December 2020

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

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12 December 2020

Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations

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12 December 2020

Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype

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12 December 2020

Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance

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12 December 2020

Implications of NRAS mutations in AML: a study of 2502 patients

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12 December 2020

Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML).

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12 December 2020

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia

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12 December 2020

Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML.

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12 December 2020

Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1)

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12 December 2020

IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication

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12 December 2020

Prognostic impact of FLT3-ITD load in NPM1 mutated acute myeloid leukemia

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12 December 2020

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

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12 December 2020

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

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12 December 2020

The level of residual disease based on mutant NPM1 is an independent prognostic factor for relapse and survival in AML.

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12 December 2020

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

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12 December 2020

Phase I trial of maintenance sorafenib after allogeneic hematopoietic stem cell transplantation for fms-like tyrosine kinase 3 internal tandem duplication acute myeloid leukemia

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12 December 2020

Allogeneic stem-cell transplantation in patients with NPM1-mutated acute myeloid leukemia: results from a prospective donor versus no-donor analysis of patients after upfront HLA typing within the SAL-AML 2003 trial

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12 December 2020

Acute myeloid leukemia ontogeny is defined by distinct somatic mutations

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12 December 2020

DNMT3A in haematological malignancies

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12 December 2020

Prognostic significance of NPM1 mutations in the absence of FLT3-internal tandem duplication in older patients with acute myeloid leukemia: a SWOG and UK National Cancer Research Institute/Medical Research Council report

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12 December 2020

Assessment of Minimal Residual Disease in Standard-Risk AML.

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12 December 2020

Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure

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12 December 2020

Genomic Classification and Prognosis in Acute Myeloid Leukemia

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12 December 2020

Validation and Implementation of a Custom Next-Generation Sequencing Clinical Assay for Hematologic Malignancies

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12 December 2020

Pretransplant NPM1 MRD levels predict outcome after allogeneic hematopoietic stem cell transplantation in patients with acute myeloid leukemia

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12 December 2020

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

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12 December 2020

Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma.

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12 December 2020

NPM1 mutation but not RUNX1 mutation or multilineage dysplasia defines a prognostic subgroup within de novo acute myeloid leukemia lacking recurrent cytogenetic abnormalities in the revised 2016 WHO classification

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12 December 2020

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

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12 December 2020

Association of mutations with morphologic dysplasia in de novo acute myeloid leukemia without 2016 WHO Classification-defined cytogenetic abnormalities

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12 December 2020

10.1182/BLOOD-2018-01-828467

Identifiers

DOI

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PubMed publication ID

29724895

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