Matrine suppresses KRAS-driven pancreatic cancer growth by inhibiting autophagy-mediated energy metabolism. (Q55516473)

14 July 2018

title

Matrine suppresses KRAS-driven pancreatic cancer growth by inhibiting autophagy-mediated energy metabolism. (English)

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14 July 2018

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Young-Ra Cho

1

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14 July 2018

Ji Hyeon Lee

2

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14 July 2018

Ji Hye Kim

3

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14 July 2018

So-Yeon Lee

4

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14 July 2018

Suna Yoo

5

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14 July 2018

Min-Kyo Jung

6

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14 July 2018

Su Jung Kim

7

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14 July 2018

Hyun Ju Yoo

8

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14 July 2018

Chang-Gi Pack

9

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14 July 2018

Jin Kyung Rho

10

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14 July 2018

Jaekyoung Son

11

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14 July 2018

publication date

11 June 2018

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14 July 2018

published in

Molecular Oncology

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14 July 2018

volume

12

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14 July 2018

issue

7

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14 July 2018

page(s)

1203-1215

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14 July 2018

Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity

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Autophagy is required for PDAC glutamine metabolism

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15 July 2018

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Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose

15 July 2018

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15 July 2018

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Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations

15 July 2018

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15 July 2018

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Tetrandrine blocks autophagic flux and induces apoptosis via energetic impairment in cancer cells

15 July 2018

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KRAS: feeding pancreatic cancer proliferation

15 July 2018

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Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

15 July 2018

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Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance

15 July 2018

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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

15 July 2018

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Matrine induces apoptosis in human acute myeloid leukemia cells via the mitochondrial pathway and Akt inactivation

15 July 2018

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Matrine, a novel autophagy inhibitor, blocks trafficking and the proteolytic activation of lysosomal proteases

15 July 2018

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Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

15 July 2018

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Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

15 July 2018

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Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

15 July 2018

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Targeting cancer metabolism: a therapeutic window opens

15 July 2018

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15 July 2018

Proteases in autophagy

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Autophagy is involved in anticancer effects of matrine on SGC-7901 human gastric cancer cells

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Pancreatic cancers require autophagy for tumor growth

15 July 2018

1 reference

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Hallmarks of Cancer: The Next Generation

15 July 2018

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Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Matrine inhibits proliferation and induces apoptosis of pancreatic cancer cells in vitro and in vivo

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Antitumor effect of matrine in human hepatoma G2 cells by inducing apoptosis and autophagy

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-kappaB signaling

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Understanding the Warburg effect: the metabolic requirements of cell proliferation

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Matrine induces apoptosis in gastric carcinoma cells via alteration of Fas/FasL and activation of caspase-3.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Chemoradiotherapy for unresectable pancreatic cancer

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Autophagy fights disease through cellular self-digestion

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Effect of matrine on the expression of substance P receptor and inflammatory cytokines production in human skin keratinocytes and fibroblasts

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Matrine induced gastric cancer MKN45 cells apoptosis via increasing pro-apoptotic molecules of Bcl-2 family.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Antifibrotic effects of matrine on in vitro and in vivo models of liver fibrosis in rats.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Autophagy, Metabolism, and Cancer.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Antiarrhythmic properties of long-term treatment with matrine in arrhythmic rat induced by coronary ligation

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Impaired autophagosome-lysosome fusion in the pathogenesis of pancreatitis.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Efficacy of intramuscular matrine in the treatment of chronic hepatitis B.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6026868

Effect of matrine on HeLa cell adhesion and migration

12 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29791786

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/1878-0261.12324

1 reference

14 July 2018

PMC publication ID

6026868

1 reference

14 July 2018

PubMed publication ID

29791786

1 reference

14 July 2018