Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas. (Q55463299)

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English	Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas.	scientific article

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Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/21425258

Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas. (English)

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Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/21425258

DNA mismatch repair

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based on heuristic

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Michael Weller

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12 July 2018

Guido Reifenberger

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Guido Reifenberger

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Jörg Felsberg

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12 July 2018

Jörg-Christian Tonn

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Jörg C Tonn

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http://europepmc.org/abstract/MED/21425258

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Niklas Thon

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12 July 2018

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Sabina Eigenbrod

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Bettina Hentschel

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Michael C Sabel

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http://europepmc.org/abstract/MED/21425258

Manfred Westphal

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Gabriele Schackert

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Friedrich Wilhelm Kreth

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Torsten Pietsch

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http://europepmc.org/abstract/MED/21425258

Markus Löffler

10

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German Glioma Network

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1 August 2011

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12 July 2018

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International Journal of Cancer

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129

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http://europepmc.org/abstract/MED/21425258

3

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659-670

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12 July 2018

http://europepmc.org/abstract/MED/21425258

Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas

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Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment

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MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance.

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant glioma

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Rapid and sensitive assessment of the IDH1 and IDH2 mutation status in cerebral gliomas based on DNA pyrosequencing

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Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors.

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Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis

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Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

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O(6)-methylguanine DNA-methyltransferase methylation status can change between first surgery for newly diagnosed glioblastoma and second surgery for recurrence: clinical implications

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Mechanisms of chemoresistance to alkylating agents in malignant glioma

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Careful exclusion of non-neoplastic brain components is required for an appropriate evaluation of O6-methylguanine-DNA methyltransferase status in glioma: relationship between immunohistochemistry and methylation analysis

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Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network

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O6-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients

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The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome: from bench to bedside

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Molecular mechanisms associated with chromosomal and microsatellite instability in sporadic glioblastoma multiforme.

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Microsatellite instability and mutation of DNA mismatch repair genes in gliomas.

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Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene.

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21 January 2018

Promoter hypermethylation of mismatch repair gene hMLH1 predicts the clinical response of malignant astrocytomas to nitrosourea

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Epigenetic inactivation of the hMLH1 gene in progression of gliomas

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Temozolomide and carmustine cause large-scale heterochromatin reorganization in glioma cells

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21 January 2018

Identifiers

10.1002/IJC.26083

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/21425258

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/21425258

ResearchGate publication ID

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