Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes. (Q55209075)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29695609 AND SRC:MED&resulttype=core&format=json

24 March 2020

title

Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes (English)

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24 March 2020

8

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24 March 2020

Louis Dwomoh

6

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24 March 2020

Patrick M. Sexton

10

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24 March 2020

Christopher J Langmead

15

object named as

Christopher J Langmead

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24 March 2020

12

Arthur Christopoulos

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24 March 2020

1

Sophie J Bradley

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24 March 2020

4

Adrian J Mogg

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24 March 2020

13

Lisa M Broad

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24 March 2020

14

Andrew B Tobin

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24 March 2020

author name string

Colin Molloy

2

1 reference

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24 March 2020

Christoffer Bundgaard

3

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24 March 2020

Karen J Thompson

5

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24 March 2020

Helen E Sanger

7

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24 March 2020

Simon M Brooke

9

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24 March 2020

Christian C Felder

11

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24 March 2020

publication date

25 April 2018

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24 March 2020

published in

Molecular Pharmacology

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24 March 2020

volume

93

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24 March 2020

issue

6

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24 March 2020

page(s)

645-656

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Design and Synthesis of γ- and δ-Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1-Selective PAM with Weak Agonist Activity

24 March 2020

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Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptors

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Determination of [35S]guanosine-5'-O-(3-thio)triphosphate binding mediated by cholinergic muscarinic receptors in membranes from Chinese hamster ovary cells and rat striatum using an anti-G protein scintillation proximity assay.

30 June 2018

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13 August 2018

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13 August 2018

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13 August 2018

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Scopolamine Impairs Acquisition and Facilitates Consolidation of Fear Conditioning: Differential Effects for Tone vs Context Conditioning

13 August 2018

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13 August 2018

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Localization of a family of muscarinic receptor mRNAs in rat brain

29 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29695609

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expression of m1-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29695609

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/MOL.118.111872

1 reference

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24 March 2020

1 reference

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24 March 2020

PubMed publication ID

29695609

1 reference