GSK-3β inhibition promotes engraftment of ex vivo-expanded hematopoietic stem cells and modulates gene expression. (Q54640874)

2 June 2018

title

GSK-3β inhibition promotes engraftment of ex vivo-expanded hematopoietic stem cells and modulates gene expression. (English)

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author

Robert E. Nordon

5

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author name string

Kap-Hyoun Ko

1

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Tiffany Holmes

2

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Patricia Palladinetti

3

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Emma Song

4

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Tracey A O'Brien

6

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Alla Dolnikov

7

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publication date

1 January 2011

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2 June 2018

published in

Stem Cells

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volume

29

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issue

1

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page(s)

108-118

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Umbilical cord blood transplantation: a new alternative option

cites work

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Augmentation of umbilical cord blood (UCB) transplantation with ex vivo-expanded UCB cells: results of a phase 1 trial using the AastromReplicell System

21 January 2018

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Characterization of serum-free ex vivo-expanded hematopoietic stem cells derived from human umbilical cord blood CD133( ) cells

21 January 2018

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Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution

21 January 2018

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Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block

21 January 2018

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Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation

21 January 2018

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Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.

21 January 2018

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Glycogen synthase kinase-3beta inhibition preserves hematopoietic stem cell activity and inhibits leukemic cell growth

21 January 2018

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Comparison of human placenta- and bone marrow-derived multipotent mesenchymal stem cells

21 January 2018

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Analysis of cell differentiation by division tracking cytometry

21 January 2018

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

21 January 2018

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GSK-3-selective inhibitors derived from Tyrian purple indirubins

21 January 2018

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The late dividing population of gamma-retroviral vector transduced human mobilized peripheral blood progenitor cells contributes most to gene-marked cell engraftment in nonobese diabetic/severe combined immunodeficient mice

21 January 2018

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Umbilical cord blood progeny cells that retain a CD34 phenotype after ex vivo expansion have less engraftment potential than unexpanded CD34 cells.

21 January 2018

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Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

21 January 2018

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Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells.

21 January 2018

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Marrow stem cells shift gene expression and engraftment phenotype with cell cycle transit

21 January 2018

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Heme oxygenase-1: a novel therapeutic target in oxidative tissue injuries

21 January 2018

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A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

21 January 2018

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Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production.

21 January 2018

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Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation.

21 January 2018

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In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C.

21 January 2018

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Mouse development and cell proliferation in the absence of D-cyclins.

21 January 2018

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Necdin restricts proliferation of hematopoietic stem cells during hematopoietic regeneration

21 January 2018

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A novel assay to trace proliferation history in vivo reveals that enhanced divisional kinetics accompany loss of hematopoietic stem cell self-renewal

21 January 2018

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Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

21 January 2018

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A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

21 January 2018

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Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways

21 January 2018

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Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells

21 January 2018

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Prompt and durable engraftment in two older adult patients with high risk chronic myelogenous leukemia (CML) using ex vivo expanded and unmanipulated unrelated umbilical cord blood

21 January 2018

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Hematopoietic stem cell and multilineage defects generated by constitutive β-catenin activation

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/STEM.551

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2 June 2018

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2 June 2018