Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907 (Q54631286)

1 June 2018

title

Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21098738

1 September 2024

0 references

8

Hans-Ulrich Häring

1 reference

1 June 2018

10

Cora Weigert

1 reference

1 June 2018

Erwin Schleicher

9

object named as

Erwin D Schleicher

1 reference

1 June 2018

author name string

Louise Fritsche

1

1 reference

1 June 2018

Rainer Lehmann

3

1 reference

1 June 2018

Elisabeth Kremmer

4

1 reference

1 June 2018

Andrea Hunder-Gugel

6

1 reference

1 June 2018

Martin Schenk

7

1 reference

1 June 2018

Sabine S. Neukamm

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21098738

1 September 2024

Anita M. Hennige

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21098738

1 September 2024

Erwin D. Schleicher

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21098738

1 September 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21098738

1 September 2024

publication date

23 November 2010

1 reference

1 June 2018

American Journal of Physiology - Endocrinology and Metabolism

published in

1 reference

1 June 2018

volume

300

1 reference

1 June 2018

issue

5

1 reference

1 June 2018

page(s)

E824-36

1 reference

1 June 2018

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

cites work

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Altered Expression Levels and Impaired Steps in the Pathway to Phosphatidylinositol 3-Kinase Activation via Insulin Receptor Substrates 1 and 2 in Zucker Fatty Rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Phosphorylation of IRS proteins, insulin action, and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation and Function by Mitogen-activated Protein Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

A quantitative atlas of mitotic phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Elimination of negative feedback control mechanisms along the insulin signaling pathway improves beta-cell function under stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Prevention of fat-induced insulin resistance by salicylate

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Phosphorylation of human insulin receptor substrate-1 at Serine 629 plays a positive role in insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Identification, analysis, and prediction of protein ubiquitination sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Chapter 4 Preparation of Isolated Rat Liver Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

The function of GRB2 in linking the insulin receptor to Ras signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Role of IRS-2 in insulin and cytokine signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Critical nodes in signalling pathways: insights into insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Interplay and effects of temporal changes in the phosphorylation state of serine-302, -307, and -318 of insulin receptor substrate-1 on insulin action in skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

Global Assessment of Regulation of Phosphorylation of Insulin Receptor Substrate-1 by Insulin In Vivo in Human Muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152/AJPENDO.00409.2010

10.1152/AJPENDO.00409.2010

21 January 2018

Identifiers

DOI

1 reference

1 June 2018

1 reference

1 June 2018