Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45. (Q54537231)

31 May 2018

title

Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45. (English)

1 reference

31 May 2018

author name string

Ryohei Wakahara

1

1 reference

31 May 2018

Hiroyuki Kunimoto

2

1 reference

31 May 2018

Kanae Tanino

3

1 reference

31 May 2018

Hirotada Kojima

4

1 reference

31 May 2018

Akira Inoue

5

1 reference

31 May 2018

Haruo Shintaku

6

1 reference

31 May 2018

Koichi Nakajima

7

1 reference

31 May 2018

publication date

11 January 2012

1 reference

31 May 2018

published in

Genes to Cells

1 reference

31 May 2018

volume

17

1 reference

31 May 2018

issue

2

1 reference

31 May 2018

page(s)

132-145

1 reference

31 May 2018

The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway

cites work

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Insulin antagonizes interleukin-6 signaling and is anti-inflammatory in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

STATs and Gene Regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Serine phosphorylation of STATs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Signaling mechanisms through gp130: a model of the cytokine system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Identification of a nuclear Stat1 protein tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Stats: transcriptional control and biological impact

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

A Novel Sequence in the Coiled-coil Domain of Stat3 Essential for Its Nuclear Translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

STAT3 inhibition of gluconeogenesis is downregulated by SirT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Physical and functional interactions between STAT3 and ZIP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Phosphorylation of STAT3 serine-727 by cyclin-dependent kinase 1 is critical for nocodazole-induced mitotic arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Regulation of Stat3 transcriptional activity by the conserved LPMSP motif for OSM and IL-6 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

SOCS proteins, cytokine signalling and immune regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Stat3 dimerization regulated by reversible acetylation of a single lysine residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

Region 752-761 of STAT3 is critical for SRC-1 recruitment and Ser727 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1365-2443.2011.01575.X

10.1111/J.1365-2443.2011.01575.X

21 January 2018

Identifiers

DOI

1 reference

31 May 2018

1 reference

31 May 2018