fibroblast growth factor receptor 1 (Q5446453)

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mammalian protein found in Homo sapiens
  • FGFR1
  • heparin-binding growth factor receptor
  • FGFR1/PLAG1 fusion
  • FMS-like tyrosine kinase 2
  • hydroxyaryl-protein kinase
  • fibroblast growth factor receptor 1
  • BFGFR
  • FLT-2
  • basic fibroblast growth factor receptor 1
  • N-sam
  • fms-related tyrosine kinase 2
  • proto-oncogene c-Fgr
  • bFGF-R-1
edit
Language Label Description Also known as
English
fibroblast growth factor receptor 1
mammalian protein found in Homo sapiens
  • FGFR1
  • heparin-binding growth factor receptor
  • FGFR1/PLAG1 fusion
  • FMS-like tyrosine kinase 2
  • hydroxyaryl-protein kinase
  • fibroblast growth factor receptor 1
  • BFGFR
  • FLT-2
  • basic fibroblast growth factor receptor 1
  • N-sam
  • fms-related tyrosine kinase 2
  • proto-oncogene c-Fgr
  • bFGF-R-1

Statements

part of
molecular function
protein binding
determination method or standard
IPI
23 references
retrieved
8 April 2019
stated in
Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins
GOA
curator
UniProt
UniProt protein ID
P11362
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line
GOA
curator
UniProt
UniProt protein ID
P11362
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis for FGF receptor dimerization and activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Fibroblast growth factor receptor 1- 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cgamma at the centrosome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Grb14 inhibits FGF receptor signaling through the regulation of PLCγ recruitment and activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
fibroblast growth factor-activated receptor activity
determination method or standard
IEA
TAS
IDA
6 references
retrieved
27 February 2018
stated in
Diverse forms of a receptor for acidic and basic fibroblast growth factors
GOA
curator
UniProt
UniProt protein ID
P11362
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11362&geneProductId=UniProtKB:P11362
determination method or standard
TAS
retrieved
27 February 2018
stated in
A novel type I fibroblast growth factor receptor activates mitogenic signaling in the absence of detectable tyrosine phosphorylation of FRS2
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11362&geneProductId=UniProtKB:P11362
determination method or standard
TAS
retrieved
27 February 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11362&geneProductId=UniProtKB:P11362
determination method or standard
IEA
retrieved
27 February 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11362&geneProductId=UniProtKB:P11362
determination method or standard
IEA
retrieved
27 February 2018
stated in
Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis
GOA
curator
UniProt
UniProt protein ID
P11362
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11362&geneProductId=UniProtKB:P11362
determination method or standard
IDA
retrieved
27 February 2018
stated in
Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells
GOA
curator
UniProt
UniProt protein ID
P11362
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11362&geneProductId=UniProtKB:P11362
determination method or standard
IDA
fibroblast growth factor-activated receptor activity
determination method or standard
IBA
IDA
IEA
TAS
7 references
retrieved
8 April 2019
stated in
Diverse forms of a receptor for acidic and basic fibroblast growth factors
GOA
curator
UniProt
UniProt protein ID
P11362
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
TAS
retrieved
8 April 2019
stated in
A novel type I fibroblast growth factor receptor activates mitogenic signaling in the absence of detectable tyrosine phosphorylation of FRS2
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IEA
retrieved
8 April 2019
stated in
Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis
GOA
curator
UniProt
UniProt protein ID
P11362
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IDA
retrieved
8 April 2019
stated in
Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells
GOA
curator
UniProt
UniProt protein ID
P11362
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IBA
cell component
biological process
fibroblast growth factor receptor signaling pathway
determination method or standard
IEA
TAS
IPI
IDA
IGI
8 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
TAS
retrieved
8 April 2019
stated in
Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
TAS
retrieved
8 April 2019
stated in
A novel type I fibroblast growth factor receptor activates mitogenic signaling in the absence of detectable tyrosine phosphorylation of FRS2
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
TAS
retrieved
8 April 2019
stated in
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IPI
retrieved
8 April 2019
stated in
Receptor specificity of the fibroblast growth factor family
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IGI
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IEA
retrieved
8 April 2019
stated in
Receptor specificity of the fibroblast growth factor family
GOA
curator
UniProt
UniProt protein ID
P11362
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IDA
positive regulation of cell population proliferation
determination method or standard
IBA
IDA
IEA
IGI
IMP
6 references
retrieved
8 April 2019
stated in
Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction
GOA
curator
UniProt
UniProt protein ID
P11362
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IMP
retrieved
8 April 2019
stated in
Receptor specificity of the fibroblast growth factor family
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IGI
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IEA
retrieved
8 April 2019
stated in
Receptor specificity of the fibroblast growth factor family
GOA
curator
UniProt
UniProt protein ID
P11362
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11362
determination method or standard
IBA
Gene Atlas image
PBB GE FGFR1 211535 s at fs.png
732 × 530; 12 KB
0 references
has part(s)

Identifiers

MeSH descriptor ID
D051496
subject named as
Receptor, Fibroblast Growth Factor, Type 1
0 references
RefSeq protein ID
Ensembl protein ID
PDB structure ID
 
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