E2F-1 induces the stabilization of p53 but blocks p53-mediated transactivation. (Q54393600)

29 May 2018

title

E2F-1 induces the stabilization of p53 but blocks p53-mediated transactivation. (English)

1 reference

29 May 2018

author name string

Nip J

1

1 reference

29 May 2018

Strom DK

2

1 reference

29 May 2018

Eischen CM

3

1 reference

29 May 2018

Cleveland JL

4

1 reference

29 May 2018

Zambetti GP

5

1 reference

29 May 2018

Hiebert SW

6

1 reference

29 May 2018

language of work or name

English

0 references

publication date

1 February 2001

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29 May 2018

published in

Oncogene

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29 May 2018

volume

20

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29 May 2018

issue

8

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29 May 2018

page(s)

910-920

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29 May 2018

Transcriptional control by E2F

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Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2

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Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo

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Retinoblastoma protein recruits histone deacetylase to repress transcription

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Direct transcriptional repression by pRB and its reversal by specific cyclins

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The E2F transcription factor is a cellular target for the RB protein

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Mapping of the p53 and mdm-2 Interaction Domains

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Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

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Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

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Distinct roles for E2F proteins in cell growth control and apoptosis

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Differential regulation of E2F transactivation by cyclin/cdk2 complexes

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The p53 proto-oncogene can act as a suppressor of transformation

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The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

21 January 2018

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Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation

21 January 2018

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Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression

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The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F

21 January 2018

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E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis

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E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

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Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

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Expression of transcription factor E2F1 induces quiescent cells to enter S phase

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

21 January 2018

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Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

21 January 2018

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Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members

21 January 2018

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Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

21 January 2018

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Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining

21 January 2018

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Wild-type p53 is a cell cycle checkpoint determinant following irradiation

21 January 2018

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DP and E2F proteins: components of a heterodimeric transcription factor implicated in cell cycle control

21 January 2018

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Cancer. p53, guardian of the genome

21 January 2018

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

21 January 2018

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Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

21 January 2018

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

21 January 2018

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Retinoblastoma protein represses transcription by recruiting a histone deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

21 January 2018

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1204171

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

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Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.

21 January 2018

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Wild-type p53 negatively regulates the expression of a microtubule-associated protein

21 January 2018

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E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis

21 January 2018

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Regulation of the cyclin E gene by transcription factor E2F1

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Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells

21 January 2018

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Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

21 January 2018

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The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

21 January 2018

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Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

21 January 2018

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

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Growth regulation of a cellular tumour antigen, p53, in nontransformed cells

21 January 2018

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The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

21 January 2018

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Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein

21 January 2018

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The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

Inhibitors of mammalian G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

Functional interaction between DP-1 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

The CBP co-activator stimulates E2F1/DP1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

E2F1 and E1A(12S) have a homologous activation domain regulated by RB and CBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

Retinoblastoma protein switches the E2F site from positive to negative element

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

p53 and E2F-1 cooperate to mediate apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

7 January 2021

Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

7 January 2021

Role of E2F transcription factor in E1A-mediated trans activation of cellular genes

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

7 January 2021

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

7 January 2021

Cancer therapy and p53.

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https://api.crossref.org/works/10.1038/SJ.ONC.1204171

7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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https://api.crossref.org/works/10.1038/SJ.ONC.1204171

7 January 2021

Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

7 January 2021

Tumor suppressor genes

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1204171

7 January 2021

Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204171

1 reference

29 May 2018

1 reference

29 May 2018