Feedbacks and adaptive capabilities of the PI3K/Akt/mTOR axis in acute myeloid leukemia revealed by pathway selective inhibition and phosphoproteome analysis. (Q54362642)

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English	Feedbacks and adaptive capabilities of the PI3K/Akt/mTOR axis in acute myeloid leukemia revealed by pathway selective inhibition and phosphoproteome analysis.	scientific article

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12 March 2020

Feedbacks and adaptive capabilities of the PI3K/Akt/mTOR axis in acute myeloid leukemia revealed by pathway selective inhibition and phosphoproteome analysis (English)

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12 March 2020

acute myeloid leukemia

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Sandra Marmiroli

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12 March 2020

Jessika Bertacchini

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12 March 2020

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Patrizia Barozzi

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12 March 2020

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M Guida

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B Accordi

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A M Martelli

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E Petricoin

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L Liotta

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G Milani

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M Giordan

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12 March 2020

F Forghieri

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L Cocco

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12 March 2020

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4 April 2014

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12 March 2020

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12 March 2020

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12 March 2020

2197-2205

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12 March 2020

Gene expression profiling in MDS and AML: potential and future avenues.

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FLT3 inhibition: a moving and evolving target in acute myeloid leukaemia

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Targeting the KIT activating switch control pocket: a novel mechanism to inhibit neoplastic mast cell proliferation and mast cell activation

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The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients.

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Functional proteomic profiling of AML predicts response and survival

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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The nuts and bolts of AGC protein kinases

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

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Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment

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Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

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The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.

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Targeting the PI3K/Akt/mTOR signaling pathway in B-precursor acute lymphoblastic leukemia and its therapeutic potential.

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Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

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A phase Ib GOELAMS study of the mTOR inhibitor RAD001 in association with chemotherapy for AML patients in first relapse.

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Development of PI3K inhibitors: lessons learned from early clinical trials

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mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin

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Phase I study of quizartinib administered daily to patients with relapsed or refractory acute myeloid leukemia irrespective of FMS-like tyrosine kinase 3-internal tandem duplication status

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Pharmacological inhibition of protein kinase CK2 reverts the multidrug resistance phenotype of a CEM cell line characterized by high CK2 level.

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Drug combination studies and their synergy quantification using the Chou-Talalay method

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The protein kinase Akt/PKB regulates both prelamin A degradation and Lmna gene expression

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Reverse-phase protein microarrays for theranostics and patient tailored therapy

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Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody

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Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia

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Targeting mTOR for the treatment of AML. New agents and new directions

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The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism

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AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines

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Small-molecule inhibitors of the PI3K signaling network

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AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

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Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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Phosphoprotein pathway mapping: Akt/mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

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Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases

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mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling

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Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways.

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Global phosphoproteome analysis of human bone marrow reveals predictive phosphorylation markers for the treatment of acute myeloid leukemia with quizartinib

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The pharmacology of mTOR inhibition

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In vivo analysis of insulin-like growth factor type 1 receptor humanized monoclonal antibody MK-0646 and small molecule kinase inhibitor OSI-906 in colorectal cancer.

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based on heuristic

inferred from PubMed ID database lookup

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10.1038/LEU.2014.123

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302 AND SRC:MED&resulttype=core&format=json

12 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24699302 AND SRC:MED&resulttype=core&format=json

12 March 2020

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