LRRK2 mediated Rab8a phosphorylation promotes lipid storage. (Q54124348)

http://europepmc.org/abstract/PMC/5828482

25 May 2018

title

LRRK2 mediated Rab8a phosphorylation promotes lipid storage. (English)

1 reference

http://europepmc.org/abstract/PMC/5828482

25 May 2018

0 references

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29482628 AND SRC:MED&resulttype=core&format=json

5 June 2020

author name string

Miao Yu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29482628 AND SRC:MED&resulttype=core&format=json

5 June 2020

Muhammad Arshad

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29482628 AND SRC:MED&resulttype=core&format=json

5 June 2020

Wenmin Wang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29482628 AND SRC:MED&resulttype=core&format=json

5 June 2020

Dongyu Zhao

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29482628 AND SRC:MED&resulttype=core&format=json

5 June 2020

Li Xu

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29482628 AND SRC:MED&resulttype=core&format=json

5 June 2020

publication date

27 February 2018

1 reference

http://europepmc.org/abstract/PMC/5828482

25 May 2018

published in

Lipids in Health and Disease

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29482628 AND SRC:MED&resulttype=core&format=json

5 June 2020

volume

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29482628 AND SRC:MED&resulttype=core&format=json

5 June 2020

issue

1

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5 June 2020

page(s)

34

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29482628 AND SRC:MED&resulttype=core&format=json

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

5 June 2020

cites work

1 reference

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Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.

25 May 2018

1 reference

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Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration

25 May 2018

1 reference

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Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Phosphorylation of Rab5a protein by protein kinase Cϵ is crucial for T-cell migration.

25 May 2018

1 reference

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Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

A peroxisome biogenesis deficiency prevents the binding of alpha-synuclein to lipid droplets in lipid-loaded yeast

25 May 2018

1 reference

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Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes

25 May 2018

1 reference

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Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells

25 May 2018

1 reference

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Rab8 GTPase as a regulator of cell shape

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Milestones in Parkinson's disease--clinical and pathologic features

25 May 2018

1 reference

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Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Impairment of protein trafficking upon overexpression and mutation of optineurin

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Alpha-synuclein, lipids and Parkinson's disease

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Rab8 interacts with distinct motifs in alpha2B- and beta2-adrenergic receptors and differentially modulates their transport

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Lipid droplets finally get a little R-E-S-P-E-C-T.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Rab GTPases as coordinators of vesicle traffic

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Metabolic abnormalities associated with mild cognitive impairment in Parkinson disease

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Tyrosine phosphorylation of the Rab24 GTPase in cultured mammalian cells

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Rab GTPases, intracellular traffic and disease.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Tyrosine phosphorylation of Rab proteins

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Membrane targeting of the small GTPase Rab9 is accompanied by nucleotide exchange

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828482

Lipid droplet and microfilaments in a neuron

13 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29482628

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29482628

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Rab family of proteins: 25 years on

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29482628

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/S12944-018-0684-X

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29482628 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

5 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29482628 AND SRC:MED&resulttype=core&format=json

5 June 2020

PubMed publication ID

29482628

1 reference