The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner. (Q53720891)

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English	The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner.	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner. (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

tumor angiogenesis

1 reference

based on heuristic

inferred from title

breast neoplasm

1 reference

based on heuristic

inferred from title

Ivan Topisirovic

8

1 reference

Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

author name string

Y K Im

1

1 reference

Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

R La Selva

2

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Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

V Gandin

3

1 reference

Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

J R Ha

4

1 reference

Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

V Sabourin

5

1 reference

Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

N Sonenberg

6

1 reference

Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

T Pawson

7

1 reference

Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

J Ursini-Siegel

9

1 reference

Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

language of work or name

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publication date

19 May 2014

1 reference

Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

1 reference

Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

34

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Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

13

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Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

1729-1735

1 reference

Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

Multiple ErbB-2/Neu Phosphorylation Sites Mediate Transformation through Distinct Effector Proteins.

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Combinatorial ShcA docking interactions support diversity in tissue morphogenesis

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

ShcA signalling is essential for tumour progression in mouse models of human breast cancer

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

mTOR: from growth signal integration to cancer, diabetes and ageing

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Dissecting the role of mTOR: lessons from mTOR inhibitors

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Translational homeostasis via the mRNA cap-binding protein, eIF4E

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

A multiple ribosomal structure in protein synthesis

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

The translational landscape of mTOR signalling steers cancer initiation and metastasis

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

A unifying model for mTORC1-mediated regulation of mRNA translation.

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Distinct perturbation of the translatome by the antidiabetic drug metformin

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

p53-dependent translational control of senescence and transformation via 4E-BPs.

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Vascular endothelial growth factor induces proliferation of breast cancer cells and inhibits the anti-proliferative activity of anti-hormones

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Knockdown of VEGF receptor-1 (VEGFR-1) impairs macrophage infiltration, angiogenesis and growth of clear cell renal cell carcinoma (CRCC)

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinoma

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

eIF4F suppression in breast cancer affects maintenance and progression

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer.

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Eukaryotic initiation factor 4E overexpression in triple-negative breast cancer predicts a worse outcome.

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Ribavirin Treatment Effects on Breast Cancers Overexpressing eIF4E, a Biomarker with Prognostic Specificity for Luminal B-Type Breast Cancer

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Formation of the eIF4F translation-initiation complex determines sensitivity to anticancer drugs targeting the EGFR and HER2 receptors.

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Dual mTORC1/2 and HER2 blockade results in antitumor activity in preclinical models of breast cancer resistant to anti-HER2 therapy

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Inhibition of mammalian target of rapamycin is required for optimal antitumor effect of HER2 inhibitors against HER2-overexpressing cancer cells

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

21 January 2018

Translational regulation of vascular permeability factor by eukaryotic initiation factor 4E: implications for tumor angiogenesis

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

31 March 2020

Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.110

31 March 2020

Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/24837366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A critical role for ras-mediated, epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24837366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shc proteins are strong, independent prognostic markers for both node-negative and node-positive primary breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/24837366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of initiation factor eIF-4E does not relieve the translational repression of ribosomal protein mRNAs in quiescent cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24837366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of vascular endothelial growth factor in breast cancer cells by the heregulin-beta1-activated p38 signaling pathway enhances endothelial cell migration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24837366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24837366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/ONC.2014.110

1 reference

Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 May 2018

http://europepmc.org/abstract/MED/24837366

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