The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. (Q53651908)

16 May 2018

title

The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. (English)

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16 May 2018

author

Adam Hurlstone

6

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Angeliki Malliri

object named as

Angeliki Malliri

1

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Hans Clevers

7

object named as

Hans Clevers

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16 May 2018

author name string

Tomasz P Rygiel

2

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16 May 2018

Rob A van der Kammen

3

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16 May 2018

Ji-Ying Song

4

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16 May 2018

Rainer Engers

5

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John G Collard

8

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16 May 2018

language of work or name

English

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publication date

25 October 2005

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16 May 2018

Journal of Biological Chemistry

published in

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16 May 2018

volume

281

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16 May 2018

issue

1

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16 May 2018

page(s)

543-548

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16 May 2018

Convergence of Wnt, beta-catenin, and cadherin pathways

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Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

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Wnt signalling induces maturation of Paneth cells in intestinal crypts

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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

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Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

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Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1.

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Linking colorectal cancer to Wnt signaling

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Identification of FAP locus genes from chromosome 5q21

21 January 2018

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

21 January 2018

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Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

21 January 2018

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A role for Rac in Tiam1-induced membrane ruffling and invasion

21 January 2018

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Rho and Rac take center stage

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RAS and RHO GTPases in G1-phase cell-cycle regulation

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The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions

21 January 2018

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Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition

21 January 2018

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Regulation of Tiam1-Rac signalling.

21 January 2018

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Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

21 January 2018

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Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

21 January 2018

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Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector

21 January 2018

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Identification of c-MYC as a target of the APC pathway

21 January 2018

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Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

21 January 2018

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Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling

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PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs

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Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas

21 January 2018

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Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

21 January 2018

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Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells

21 January 2018

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Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

21 January 2018

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Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis

21 January 2018

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EphB receptor activity suppresses colorectal cancer progression

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M507582200

The guanine nucleotide exchange factor Tiam1 increases colon carcinoma growth at metastatic sites in an orthotopic nude mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M507582200

Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

21 January 2018

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Mutated APC and Asef are involved in the migration of colorectal tumour cells

21 January 2018

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Role of Rho-family proteins in cell adhesion and cancer.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M507582200

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16 May 2018

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16 May 2018