Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. (Q53626941)

16 May 2018

title

Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. (English)

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16 May 2018

author name string

Aude Dupré

series ordinal

1

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16 May 2018

Louise Boyer-Chatenet

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2

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16 May 2018

Jean Gautier

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3

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16 May 2018

publication date

23 April 2006

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16 May 2018

Nature Structural & Molecular Biology

published in

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16 May 2018

volume

13

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issue

5

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16 May 2018

page(s)

451-457

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16 May 2018

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

cites work

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

31 March 2020

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The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

31 March 2020

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

31 March 2020

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

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The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

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SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

31 March 2020

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Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest

31 March 2020

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Requirement of the MRN complex for ATM activation by DNA damage

31 March 2020

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The Mre11 complex is required for ATM activation and the G2/M checkpoint

31 March 2020

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Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

31 March 2020

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Mre11 assembles linear DNA fragments into DNA damage signaling complexes

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ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

31 March 2020

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

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Specific recruitment of human cohesin to laser-induced DNA damage

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Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks.

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Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

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Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.

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Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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Active role for nibrin in the kinetics of atm activation

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Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

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Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage

31 March 2020

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Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses

31 March 2020

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The MRN complex: coordinating and mediating the response to broken chromosomes

31 March 2020

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The rad50 signature motif: essential to ATP binding and biological function

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Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains

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DNA damage checkpoint and repair centers

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The ATRs, ATMs, and TORs are giant HEAT repeat proteins.

31 March 2020

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Shelterin: the protein complex that shapes and safeguards human telomeres

31 March 2020

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Protein phosphatase 2A is required for the initiation of chromosomal DNA replication

31 March 2020

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Isolation and characterization of Xenopus ATM (X-ATM): expression, localization, and complex formation during oogenesis and early development

31 March 2020

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Simulation of DNA fragment distributions after irradiation with photons

31 March 2020

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The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NSMB1090

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16 May 2018

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16 May 2018