'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. (Q53562298)

15 May 2018

title

'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. (English)

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15 May 2018

author

Wilfried Ellmeier

9

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author name string

Jung-Hyun Park

1

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15 May 2018

Stanley Adoro

2

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Philip J Lucas

3

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Sophia D Sarafova

4

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Amala S Alag

5

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Loretta L Doan

6

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Batu Erman

7

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Xiaolong Liu

8

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Remy Bosselut

10

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Lionel Feigenbaum

11

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Alfred Singer

12

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language of work or name

English

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publication date

16 September 2007

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15 May 2018

published in

Nature Immunology

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volume

8

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issue

10

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page(s)

1049-1059

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15 May 2018

The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery

cites work

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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

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Regulation of mature T cell homeostasis

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IL-7 is critical for homeostatic proliferation and survival of naive T cells

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Differential requirements for survival and proliferation of CD8 naïve or memory T cells

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Cell biology of IL-7, a key lymphotrophin

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IL-7 administration alters the CD4:CD8 ratio, increases T cell numbers, and increases T cell function in the absence of activation

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Low-affinity ligands for the TCR drive proliferation of mature CD8 T cells in lymphopenic hosts

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A role for TCR affinity in regulating naive T cell homeostasis.

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CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens.

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Peripheral "CD8 tuning" dynamically modulates the size and responsiveness of an antigen-specific T cell pool in vivo.

21 January 2018

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Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity.

21 January 2018

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Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules

21 January 2018

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IL-7 enhances the survival and maintains the size of naive T cells

21 January 2018

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In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8 T cells

21 January 2018

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Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

21 January 2018

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Asymmetric signaling requirements for thymocyte commitment to the CD4 versus CD8 T cell lineages: a new perspective on thymic commitment and selection

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Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells.

21 January 2018

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Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells.

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Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation

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An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells

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Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene

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Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation

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The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chain

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Positive and negative selection of an antigen receptor on T cells in transgenic mice.

21 January 2018

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Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development.

21 January 2018

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Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model

21 January 2018

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

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Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus

21 January 2018

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Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4 8lo transitional cells during positive selection of CD8 T cells

21 January 2018

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Regulation of T cell receptor expression in immature CD4 CD8 thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

21 January 2018

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Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR

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Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain

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Transient inhibition of interleukin 4 signaling by T cell receptor ligation

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IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes

21 January 2018

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New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

21 January 2018

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Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines

21 January 2018

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Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

21 January 2018

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Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

21 January 2018

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7 January 2021

A self-reactive T cell population that is not subject to negative selection

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7 January 2021

Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen

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7 January 2021

B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.

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7 January 2021

Nonequivalent effects of PKC activation by PMA on murine CD4 and CD8 cell-surface expression

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7 January 2021

A Region in the CD8 Gene Locus That Directs Expression to the Mature CD8 T Cell Subset in Transgenic Mice

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7 January 2021

Coreceptor reversal in the thymus: signaled CD4 8 thymocytes initially terminate CD8 transcription even when differentiating into CD8 T cells

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7 January 2021

CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision

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7 January 2021

Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes

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7 January 2021

Identifiers

DOI

10.1038/NI1512

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15 May 2018

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15 May 2018