Simultaneous Determination and Pharmacokinetics of Metolazone, Losartan and Losartan Carboxylic Acid in Rat Plasma by HPLC-ESI-MS-MS. (Q53515317)

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title

Simultaneous Determination and Pharmacokinetics of Metolazone, Losartan and Losartan Carboxylic Acid in Rat Plasma by HPLC-ESI-MS-MS. (English)

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author name string

Ramkumar Dubey

series ordinal

1

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Barij Nayan Sinha

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3

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Venkateswari Muthukrishnan

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4

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publication date

6 May 2015

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Journal of Chromatographic Science

published in

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volume

53

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issue

9

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page(s)

1520-1527

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Combination therapy in hypertension: An update

cites work

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Strategies for combination therapy in hypertension

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Diuretic combinations in refractory oedema states: pharmacokinetic-pharmacodynamic relationships

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EXP3174, a metabolite of losartan (MK954, DuP753) is more potent than losartan in blocking the angiotensin ll-induced responses in vascular smooth muscle cells

21 January 2018

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Pharmacokinetics and bioequivalence evaluation of two losartan potassium 50-mg tablets: A single-dose, randomized-sequence, open-label, two-way crossover study in healthy Chinese male volunteers

21 January 2018

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Pharmacokinetics of losartan and its metabolite E-3174 in relation to the CYP2C9 genotype

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Simultaneous determination of losartan and EXP3174 in human plasma and urine utilizing liquid chromatography/tandem mass spectrometry

21 January 2018

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Simultaneous quantification of losartan and active metabolite in human plasma by liquid chromatography-tandem mass spectrometry using irbesartan as internal standard

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Rapid determination of losartan and losartan acid in human plasma by multiplexed LC-MS/MS.

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An improved LC-MS/MS method for quantitative determination of metolazone in human plasma and its application to a pharmacokinetic study.

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Simultaneous determination of losartan, losartan acid and amlodipine in human plasma by LC-MS/MS and its application to a human pharmacokinetic study

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Influence of compound danshen tablet on the pharmacokinetics of losartan and its metabolite EXP3174 by liquid chromatography coupled with mass spectrometry

21 January 2018

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Simultaneous determination of metolazone and losartan potassium in their binary mixtures using high-performance liquid chromatography with fluorimetric detection: application to combined tablets and spiked human plasma

21 January 2018

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Validated RP-HPLC Method for Simultaneous Quantitation of Losartan Potassium and Metolazone in Bulk Drug and Formulation.

21 January 2018

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Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.

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Identifiers

DOI

10.1093/CHROMSCI/BMV047

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