Effects of p21 deletion in mouse models of premature aging. (Q53388774)

13 May 2018

title

Effects of p21 deletion in mouse models of premature aging. (English)

1 reference

13 May 2018

author name string

Erica K Benson

1

1 reference

13 May 2018

Bo Zhao

2

1 reference

13 May 2018

David A Sassoon

3

1 reference

13 May 2018

Sam W Lee

4

1 reference

13 May 2018

Stuart A Aaronson

5

1 reference

13 May 2018

publication date

12 July 2009

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13 May 2018

published in

Cell Cycle

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13 May 2018

volume

8

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13 May 2018

issue

13

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13 May 2018

page(s)

2002-2004

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13 May 2018

Cellular senescence and organismal ageing in the absence of p21(CIP1/WAF1) in ku80(-/-) mice

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Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

22 May 2018

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Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms

22 May 2018

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22 May 2018

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Identification of telomere-dependent "senescence-like" arrest in mouse embryonic fibroblasts

22 May 2018

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ATM function and telomere stability

22 May 2018

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Regulation of cyclin-Cdk activity in mammalian cells

22 May 2018

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Cellular senescence as a tumor-suppressor mechanism

22 May 2018

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ATM: genome stability, neuronal development, and cancer cross paths

22 May 2018

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Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression.

22 May 2018

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Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

22 May 2018

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DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

22 May 2018

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Analysis of ku80-mutant mice and cells with deficient levels of p53

22 May 2018

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Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

22 May 2018

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DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

22 May 2018

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Deletion of Ku86 causes early onset of senescence in mice

22 May 2018

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Senescence-associated beta-galactosidase histochemistry for the primate eye.

22 May 2018

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Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

22 May 2018

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p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

22 May 2018

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Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice

22 May 2018

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Essential role of mouse telomerase in highly proliferative organs

22 May 2018

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Loss of p 21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm -deficient mice

22 May 2018

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Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles

22 May 2018

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Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways

22 May 2018

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

22 May 2018

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Bypass of Senescence After Disruption of p21 CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

22 May 2018

1 reference

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p53, the cellular gatekeeper for growth and division

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839167

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839167

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839167

Atm-deficient mice: a paradigm of ataxia telangiectasia

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839167

Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839167

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839167

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

22 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839167

Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839167

Cellular senescence in aging primates.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839167

ATM and p21 cooperate to suppress aneuploidy and subsequent tumor development.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839167

Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839167

Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839167

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839167

Dual roles of ATM in the cellular response to radiation and in cell growth control.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839167

Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5839167

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

30 November 2018

1 reference

12 December 2020

Delayed kinetics of DNA double-strand break processing in normal and pathological aging

1 reference

12 December 2020

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

1 reference

12 December 2020

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

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12 December 2020

p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53

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12 December 2020

Identifiers

DOI

10.4161/CC.8.13.8997

1 reference

13 May 2018

PMC publication ID

5839167

1 reference

13 May 2018

PubMed publication ID

19535900

1 reference

13 May 2018