ATM and p53 are essential in the cell-cycle containment of DNA breaks during V(D)J recombination in vivo. (Q53359826)

13 May 2018

title

ATM and p53 are essential in the cell-cycle containment of DNA breaks during V(D)J recombination in vivo. (English)

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13 May 2018

author name string

M E Dujka

1

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13 May 2018

N Puebla-Osorio

2

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13 May 2018

O Tavana

3

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13 May 2018

M Sang

4

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13 May 2018

C Zhu

5

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13 May 2018

language of work or name

English

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publication date

16 November 2009

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13 May 2018

published in

Oncogene

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13 May 2018

volume

29

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13 May 2018

issue

7

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13 May 2018

page(s)

957-965

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13 May 2018

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

cites work

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https://api.crossref.org/works/10.1038/ONC.2009.394

Atm-deficient mice: a paradigm of ataxia telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

Aberrant V(D)J recombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

ATM stabilizes DNA double-strand-break complexes during V(D)J recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

ATM prevents the persistence and propagation of chromosome breaks in lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.394

Genomic instability in mice lacking histone H2AX

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.394

Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.394

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.394

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.394

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

Antigen receptor diversification and chromosome translocations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

No requirement for V(D)J recombination in p53-deficient thymic lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.394

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.394

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.394

Sensing of intermediates in V(D)J recombination by ATM.

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.394

AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.394

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

The V(D)J recombination activating gene, RAG-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

Interchromosomal associations between alternatively expressed loci

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.394

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.394

ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor alpha locus coding end breaks

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.394

Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

ATM controls c-Myc and DNA synthesis during postnatal thymocyte development through regulation of redox state.

21 January 2018

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https://api.crossref.org/works/10.1038/ONC.2009.394

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice

31 March 2020

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https://api.crossref.org/works/10.1038/ONC.2009.394

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

RAG2:GFP Knockin Mice Reveal Novel Aspects of RAG2 Expression in Primary and Peripheral Lymphoid Tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated

31 March 2020

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https://api.crossref.org/works/10.1038/ONC.2009.394

Separation of cells at different times within G2 and mitosis by cyclin B1 flow cytometry

31 March 2020

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https://api.crossref.org/works/10.1038/ONC.2009.394

Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.394

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.394

1 reference

13 May 2018

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13 May 2018