Matrix Rigidity Mediates TGFβ1-Induced Epithelial-Myofibroblast Transition by Controlling Cytoskeletal Organization and MRTF-A Localization. (Q53244425)

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scientific article published in August 2015

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English	Matrix Rigidity Mediates TGFβ1-Induced Epithelial-Myofibroblast Transition by Controlling Cytoskeletal Organization and MRTF-A Localization.	scientific article published in August 2015

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scholarly article

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Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/25522130

Matrix Rigidity Mediates TGFβ1-Induced Epithelial-Myofibroblast Transition by Controlling Cytoskeletal Organization and MRTF-A Localization. (English)

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Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/25522130

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5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25522130 AND SRC:MED&resulttype=core&format=json

11 June 2020

author name string

Joseph W O'Connor

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25522130 AND SRC:MED&resulttype=core&format=json

11 June 2020

Patrick N Riley

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25522130 AND SRC:MED&resulttype=core&format=json

11 June 2020

Sandeep M Nalluri

3

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11 June 2020

Parth K Ashar

4

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11 June 2020

publication date

1 August 2015

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PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/25522130

Journal of Cellular Physiology

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11 June 2020

230

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11 June 2020

8

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11 June 2020

1829-1839

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11 June 2020

The compliance of collagen gels regulates transforming growth factor-beta induction of alpha-smooth muscle actin in fibroblasts

1 reference

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Role of the actin cytoskeleton in tuning cellular responses to external mechanical stress.

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Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

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Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis-associated epithelial-to-mesenchymal transitions

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Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling

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Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes

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Role of myofibroblasts at the invasion front

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Stresses at the cell-to-substrate interface during locomotion of fibroblasts

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MKL1 mediates TGF-beta1-induced alpha-smooth muscle actin expression in human renal epithelial cells

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Substrate compliance versus ligand density in cell on gel responses

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Matrix elasticity directs stem cell lineage specification

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CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.

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Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway.

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Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis

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Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force

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Regulation of Epithelial-Mesenchymal Transition by Transmission of Mechanical Stress through Epithelial Tissues

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RPEL proteins are the molecular targets for CCG-1423, an inhibitor of Rho signaling

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Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation

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The myofibroblast: one function, multiple origins

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Cell tension, matrix mechanics, and cancer development

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Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction

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Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility

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Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts

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The basics of epithelial-mesenchymal transition

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Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

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Quantifying traction stresses in adherent cells

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Origin and function of myofibroblasts in kidney fibrosis

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New insights into the regulation of epithelial-mesenchymal transition and tissue fibrosis

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Matrix rigidity regulates a switch between TGF-β1-induced apoptosis and epithelial-mesenchymal transition

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Matrix crosslinking forces tumor progression by enhancing integrin signaling

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Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

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In situ force mapping of mammary gland transformation

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Matrix compliance and RhoA direct the differentiation of mammary progenitor cells

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21 January 2018

Directing epithelial to mesenchymal transition through engineered microenvironments displaying orthogonal adhesive and mechanical cues

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21 January 2018

Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis

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Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3

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Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis

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TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors

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Actin dynamics control SRF activity by regulation of its coactivator MAL

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Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling

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Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells

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Cell adhesion and shape regulate TGF-beta1-induced epithelial-myofibroblast transition via MRTF-A signaling

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Biomechanics of TGFβ-induced epithelial-mesenchymal transition: implications for fibrosis and cancer

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Tensional homeostasis and the malignant phenotype

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Cell locomotion and focal adhesions are regulated by substrate flexibility

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Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion

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The myofibroblast in pulmonary fibrosis

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Actin' together: serum response factor, its cofactors and the link to signal transduction

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Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies

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Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta

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The role of matrix stiffness in regulating cell behavior

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Adhesion regulates MAP kinase/ternary complex factor exchange to control a proliferative transcriptional switch

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Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line

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Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion

1 reference

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TGF-beta and epithelial-to-mesenchymal transitions

1 reference

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Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition.

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Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

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Identifiers

10.1002/JCP.24895

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25522130 AND SRC:MED&resulttype=core&format=json

11 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25522130 AND SRC:MED&resulttype=core&format=json

11 June 2020

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