Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice. (Q53229550)

12 May 2018

title

Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice. (English)

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author name string

Lamb BT

1

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Bardel KA

2

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Kulnane LS

3

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Anderson JJ

4

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Holtz G

5

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Wagner SL

6

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Sisodia SS

7

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Hoeger EJ

8

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language of work or name

English

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publication date

1 August 1999

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12 May 2018

published in

Nature Neuroscience

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volume

2

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issue

8

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page(s)

695-697

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The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

cites work

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Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice.

21 January 2018

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Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]

21 January 2018

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Mutant genes in familial Alzheimer's disease and transgenic models

21 January 2018

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The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

21 January 2018

1 reference

Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease

21 January 2018

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Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.

21 January 2018

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology

21 January 2018

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Molecular mapping of Alzheimer-type dementia in Down's syndrome

21 January 2018

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Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

21 January 2018

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Electrophoretic Separation of βA4 Peptides (1–40) and (1–42)

21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/11154

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12 May 2018

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12 May 2018