Mitogen-activated protein kinase kinase kinase 4 deficiency in intrahepatic cholangiocarcinoma leads to invasive growth and epithelial-mesenchymal transition. (Q53214123)

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scientific article published on 17 October 2015

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English	Mitogen-activated protein kinase kinase kinase 4 deficiency in intrahepatic cholangiocarcinoma leads to invasive growth and epithelial-mesenchymal transition.	scientific article published on 17 October 2015

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scholarly article

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Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/26340507

Mitogen-activated protein kinase kinase kinase 4 deficiency in intrahepatic cholangiocarcinoma leads to invasive growth and epithelial-mesenchymal transition. (English)

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Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/26340507

cholangiocarcinoma

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intrahepatic cholangiocarcinoma

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Liu-Xiao Yang

1

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12 May 2018

http://europepmc.org/abstract/MED/26340507

Qiang Gao

2

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12 May 2018

http://europepmc.org/abstract/MED/26340507

Jie-Yi Shi

3

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12 May 2018

http://europepmc.org/abstract/MED/26340507

Zhi-Chao Wang

4

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12 May 2018

http://europepmc.org/abstract/MED/26340507

Yong Zhang

5

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http://europepmc.org/abstract/MED/26340507

Ping-Ting Gao

6

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12 May 2018

http://europepmc.org/abstract/MED/26340507

Xiao-Ying Wang

7

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http://europepmc.org/abstract/MED/26340507

Ying-Hong Shi

8

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12 May 2018

http://europepmc.org/abstract/MED/26340507

Ai-Wu Ke

9

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http://europepmc.org/abstract/MED/26340507

Guo-Ming Shi

10

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http://europepmc.org/abstract/MED/26340507

Jia-Bin Cai

11

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http://europepmc.org/abstract/MED/26340507

Wei-Ren Liu

12

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http://europepmc.org/abstract/MED/26340507

Meng Duan

13

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http://europepmc.org/abstract/MED/26340507

Ying-Jun Zhao

14

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http://europepmc.org/abstract/MED/26340507

Yuan Ji

15

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http://europepmc.org/abstract/MED/26340507

Dong-Mei Gao

16

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http://europepmc.org/abstract/MED/26340507

Kai Zhu

17

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http://europepmc.org/abstract/MED/26340507

Jian Zhou

18

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http://europepmc.org/abstract/MED/26340507

Shuang-Jian Qiu

19

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http://europepmc.org/abstract/MED/26340507

Ya Cao

20

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http://europepmc.org/abstract/MED/26340507

Qi-Qun Tang

21

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http://europepmc.org/abstract/MED/26340507

Jia Fan

22

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12 May 2018

http://europepmc.org/abstract/MED/26340507

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publication date

17 October 2015

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http://europepmc.org/abstract/MED/26340507

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http://europepmc.org/abstract/MED/26340507

62

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http://europepmc.org/abstract/MED/26340507

1804-1816

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http://europepmc.org/abstract/MED/26340507

Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment

1 reference

https://api.crossref.org/works/10.1002/HEP.28149

21 January 2018

Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States

1 reference

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21 January 2018

Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies

1 reference

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Mammalian MAP kinase signalling cascades

1 reference

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Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway

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21 January 2018

A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways

1 reference

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21 January 2018

The MEK kinases MEKK4/Ssk2p facilitate complexity in the stress signaling responses of diverse systems

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21 January 2018

Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.

1 reference

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Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo.

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Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer

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MAP3Ks as central regulators of cell fate during development

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Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase

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Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients

1 reference

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Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target

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CXCR6 upregulation contributes to a proinflammatory tumor microenvironment that drives metastasis and poor patient outcomes in hepatocellular carcinoma.

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A method and server for predicting damaging missense mutations

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Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta

1 reference

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21 January 2018

Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades

1 reference

https://api.crossref.org/works/10.1002/HEP.28149

21 January 2018

Role of the amino-terminal domains of MEKKs in the activation of NF kappa B and MAPK pathways and in the regulation of cell proliferation and apoptosis.

1 reference

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21 January 2018

NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression

1 reference

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21 January 2018

Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition

1 reference

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Cancer genes and the pathways they control

1 reference

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Are common factors involved in the pathogenesis of primary liver cancers? A meta-analysis of risk factors for intrahepatic cholangiocarcinoma

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Intrahepatic cholangiocarcinoma: new insights in pathology

1 reference

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Comprehensive molecular characterization of human colon and rectal cancer

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Recurrent R-spondin fusions in colon cancer

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Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing

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Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes

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Recurrence after operative management of intrahepatic cholangiocarcinoma

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Lymphovascular and perineural invasion as selection criteria for adjuvant therapy in intrahepatic cholangiocarcinoma: a multi-institution analysis

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21 January 2018

Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase.

1 reference

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21 January 2018

p38 maintains E-cadherin expression by modulating TAK1-NF-kappa B during epithelial-to-mesenchymal transition.

1 reference

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21 January 2018

P38/NF-κB/snail pathway is involved in caffeic acid-induced inhibition of cancer stem cells-like properties and migratory capacity in malignant human keratinocyte

1 reference

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21 January 2018

Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta

1 reference

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21 January 2018

Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding

1 reference

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21 January 2018

Activation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans autophosphorylation of the MTK1 kinase domain

1 reference

https://api.crossref.org/works/10.1002/HEP.28149

21 January 2018

MEKK4 is an effector of the embryonic TRAF4 for JNK activation

1 reference

https://api.crossref.org/works/10.1002/HEP.28149

21 January 2018

CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway

1 reference

https://api.crossref.org/works/10.1002/HEP.28149

21 January 2018

HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4).

1 reference

https://api.crossref.org/works/10.1002/HEP.28149

21 January 2018

Changing pattern of epidemiology in intrahepatic cholangiocarcinoma

1 reference

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21 January 2018

p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway

1 reference

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21 January 2018

AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma: By the AFC-IHCC-2009 study group

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta

1 reference

https://api.crossref.org/works/10.1002/HEP.28149

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/HEP.28149

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/26340507

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/26340507

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