Proline-directed and non-proline-directed phosphorylation of PHF-tau. (Q53203171)

12 May 2018

title

Proline-directed and non-proline-directed phosphorylation of PHF-tau. (English)

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12 May 2018

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Morishima-Kawashima M

1

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12 May 2018

Hasegawa M

2

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12 May 2018

Takio K

3

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12 May 2018

Suzuki M

4

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12 May 2018

Yoshida H

5

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12 May 2018

Titani K

6

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12 May 2018

Ihara Y

7

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12 May 2018

language of work or name

English

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publication date

1 January 1995

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12 May 2018

Journal of Biological Chemistry

published in

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12 May 2018

volume

270

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12 May 2018

issue

2

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12 May 2018

page(s)

823-829

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12 May 2018

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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The carboxyl third of tau is tightly bound to paired helical filaments.

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Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

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Ubiquitin is a component of paired helical filaments in Alzheimer's disease.

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Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains

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A protein factor essential for microtubule assembly

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Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

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A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

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A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

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A neuronal antigen in the brains of Alzheimer patients

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Structural stability of paired helical filaments requires microtubule-binding domains of Tau: A model for self-association

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Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

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Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

21 January 2018

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Assembly of Alzheimer-like filaments from full-length tau protein

21 January 2018

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p42 map kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1Implications for Alzheimer's disease

21 January 2018

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Phosphoprotein phosphatase activities in Alzheimer disease brain

21 January 2018

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Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

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Epitopes that span the tau molecule are shared with paired helical filaments.

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Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau

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The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development

21 January 2018

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Characterization of Two Distinct Monoclonal Antibodies to Paired Helical Filaments: Further Evidence for Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments

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Fetal-type phosphorylation of the tau in paired helical filaments

21 January 2018

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Developmentally regulated expression of specific tau sequences

21 January 2018

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Application of synthetic phospho- and unphospho- peptides to identify phosphorylation sites in a subregion of the tau molecule, which is modified in Alzheimer's disease.

21 January 2018

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Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

21 January 2018

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Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease

21 January 2018

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Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site

21 January 2018

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The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs

21 January 2018

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Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments

21 January 2018

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Tau protein kinase II is involved in the regulation of the normal phosphorylation state of tau protein

21 January 2018

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Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression

21 January 2018

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21 January 2018

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p42 mitogen-activated protein kinase in brain: prominent localization in neuronal cell bodies and dendrites

21 January 2018

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Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites

21 January 2018

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A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau

21 January 2018

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Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

21 January 2018

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Protein kinase recognition sequence motifs

21 January 2018

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Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations

21 January 2018

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A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope

21 January 2018

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Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

21 January 2018

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Casein kinase II is associated with neurofibrillary tangles but is not an intrinsic component of paired helical filaments

21 January 2018

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A protein kinase associated with paired helical filaments in Alzheimer disease

21 January 2018

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Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity

21 January 2018

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Protein kinase FA/GSK-3 phosphorylates tau on Ser235-Pro and Ser404-Pro that are abnormally phosphorylated in Alzheimer's disease brain.

21 January 2018

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Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcmeurin and phosphatase-2A

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.270.2.823

1 reference

12 May 2018

1 reference

12 May 2018