Targeting of AML1-ETO in t(8;21) leukemia by oridonin generates a tumor suppressor-like protein. (Q53176666)

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27 January 2020

title

Targeting of AML1-ETO in t(8;21) leukemia by oridonin generates a tumor suppressor-like protein (English)

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Guangbiao Zhou

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Yue-Ying Wang

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Kevin Petrie

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author name string

Tao Zhen

1

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27 January 2020

Chuan-Feng Wu

2

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27 January 2020

Ping Liu

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27 January 2020

Hai-Yan Wu

4

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27 January 2020

Ying Lu

7

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Jian-Xiang Liu

8

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Yang Liang

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27 January 2020

Keqin Kathy Li

10

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27 January 2020

Yin-Yin Xie

12

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27 January 2020

Miao-Miao He

13

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27 January 2020

Huang-Ming Cao

14

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Wei-Na Zhang

15

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27 January 2020

Li-Min Chen

16

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27 January 2020

Sai-Juan Chen

18

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27 January 2020

Zhu Chen

19

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27 January 2020

language of work or name

English

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publication date

1 March 2012

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Science Translational Medicine

27 January 2020

published in

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volume

4

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issue

127

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page(s)

127ra38

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Oncogenic pathways of AML1-ETO in acute myeloid leukemia: multifaceted manipulation of marrow maturation

27 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

Targeting AML1/ETO-histone deacetylase repressor complex: a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in AML1/ETO-positive acute myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

How I treat acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

Reactive oxygen species, cellular redox systems, and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

The thioredoxin reductase/thioredoxin system: novel redox targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

Thioredoxin system inhibitors as mediators of apoptosis for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

Multi-sites cleavage of leukemogenic AML1-ETO fusion protein by caspase-3 and its contribution to increased apoptotic sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

Transforming activity of AML1-ETO is independent of CBFbeta and ETO interaction but requires formation of homo-oligomeric complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

Purification and characterization of mouse hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

Selenite induces redox-dependent Bax activation and apoptosis in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

Targeting the oligomerization domain of ETO interferes with RUNX1/ETO oncogenic activity in t(8;21)-positive leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562

Acute promyelocytic leukemia: from highly fatal to highly curable

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCITRANSLMED.3003562