Dock7: a GEF for Rho-family GTPases and a novel myosin VI-binding partner in neuronal PC12 cells. (Q53175756)

12 May 2018

title

Dock7: a GEF for Rho-family GTPases and a novel myosin VI-binding partner in neuronal PC12 cells. (English)

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5

Maria Jolanta Rędowicz

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author name string

Łukasz Majewski

1

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Magdalena Sobczak

2

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Serhiy Havrylov

3

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Jolanta Jóźwiak

4

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publication date

4 April 2012

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Biochemistry and Cell Biology

published in

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volume

90

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issue

4

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page(s)

565-574

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Myosin VI is required for targeted membrane transport during cytokinesis

cites work

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Myo6 facilitates the translocation of endocytic vesicles from cell peripheries

21 January 2018

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Myosin VI is required for sorting of AP-1B-dependent cargo to the basolateral domain in polarized MDCK cells

21 January 2018

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Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment.

21 January 2018

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Potential roles of myosin VI in cell motility

21 January 2018

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Myosin VI and optineurin are required for polarized EGFR delivery and directed migration

21 January 2018

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GEF what? Dock180 and related proteins help Rac to polarize cells in new ways

21 January 2018

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Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity

21 January 2018

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A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling

21 January 2018

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Regulation of myosin-VI targeting to endocytic compartments

21 January 2018

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Detailed tuning of structure and intramolecular communication are dispensable for processive motion of myosin VI.

21 January 2018

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The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton

21 January 2018

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DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane

21 January 2018

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Myosin VI regulates actin structure specialization through conserved cargo-binding domain sites

21 January 2018

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Rho GTPases: biochemistry and biology

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A Class VI Unconventional Myosin Is Associated with a Homologue of a Microtubule-binding Protein, Cytoplasmic Linker Protein–170, in Neurons and at the Posterior Pole of Drosophila Embryos

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Regulation of actin cytoskeleton dynamics in cells

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Myosin VI in PC12 cells plays important roles in cell migration and proliferation but not in catecholamine secretion.

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PC12 cells as a model for studies of regulated secretion in neuronal and endocrine cells

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Transport of cytoplasmic particles catalysed by an unconventional myosin in living Drosophila embryos

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Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton

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Myosin VI altered at threonine 406 stabilizes actin filaments in vivo

21 January 2018

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A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis

21 January 2018

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Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking

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The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners

21 January 2018

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Phospholipase Cδ3 is a novel binding partner of myosin VI and functions as anchoring of myosin VI on plasma membrane

21 January 2018

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Myosin VI targeting to clathrin-coated structures and dimerization is mediated by binding to Disabled-2 and PtdIns(4,5)P2.

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What can myosin VI do in cells?

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Myosin VI rewrites the rules for myosin motors

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Loss of myosin VI reduces secretion and the size of the Golgi in fibroblasts from Snell's waltzer mice

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The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18

21 January 2018

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Myosin VI is an actin-based motor that moves backwards

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Interaction of SAP97 with minus-end-directed actin motor myosin VI. Implications for AMPA receptor trafficking

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ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration

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The atypical Guanine-nucleotide exchange factor, dock7, negatively regulates schwann cell differentiation and myelination.

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BDNF-mediated neurotransmission relies upon a myosin VI motor complex

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Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer

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Developments in neuronal cell culture

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Identifiers

DOI

10.1139/O2012-009

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12 May 2018

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